Effects of Vasopeptidase Inhibition on Renal Function and Tubuloglomerular Feedback in Spontaneously Hypertensive Rats

Sympathetic Regulation of the Renal Functions in Rats Reciprocally Congenic for Chromosome 1 Blood Pressure Quantitative Trait Locus

“…Each measurement was made in duplicate. The glomerular filtration rate (GFR) was derived from the polyfructosan clearance and other renal parameters were calculated as previously described in detail (18).…”

Renal-Protective Effect of T- and L-Type Calcium Channel Blockers in Hypertensive Patients: An Amlodipine-to-Benidipine Changeover (ABC) Study

“…To decrease glomerular pressure, blood pressure (BP) must be more strictly lowered and arteriolar resistance in efferent arterioles reduced (6,7). Angiotensin II type 1 receptors are localized in both afferent and efferent arterioles (8), and angiotensin II receptor blockers (ARBs) (9) and angiotensin-converting enzyme inhibitors (ACEIs) (10) have been shown to reduce proteinuria in several multicenter randomized clinical trials.…”

Renal Protective Effect in Hypertensive Patients: The High Doses of Angiotensin II Receptor Blocker (HARB) Study

“…Reducing glomerular pressure is a principal strategy for reducing proteinuria in hypertensive patients (4). To decrease glomerular pressure, blood pressure (BP) must be lowered, and arteriolar resistance in efferent arterioles must be reduced (5,6). Angiotensin II type 1 receptors are localized to afferent and efferent arterioles (7), and angiotensin II receptor blockers (ARBs) (8) and angiotensinconverting enzyme inhibitors (ACEIs) (9) have reduced proteinuria in several multicenter randomized clinical trials.…”