Effects of Vasoconstrictors on Rabbit Coronary Arteries Exposed to Iohexol With Addition of Electrolytes (Sodium and Calcium)

Karstoft, Jens; Bååth, Lars B.; Jansen, I.; Edvinsson, Lars

doi:10.1097/00004424-199412000-00001

Cited by 4 publications

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“…Thus, the increased osmolality decreased the vasoconstrictive effect. This effect from increasing osmolalities is in accordance with previous investigations, where it was found that hyperosmolality generally decreases the vessel tone of contracted isolated vessels (3,11,18). Thus, the pronounced constriction to iotrolan developed in spite of its higher osmolality.…”

Section: Discussionsupporting

confidence: 92%

“…The ionic CM ioxaglate and diatrizaote caused no or weak constrictions like iohexol with 30 mM NaCl (Figs 2, 6). However, in the previous studies, KCl did not cause a "normal" constriction when added to ioxaglate and diatrizoate, as it did in iohexol with 30 mM NaCl (10,11). On the contrary, those media almost totally inhibited the action of KCl.…”

Section: Discussionmentioning

confidence: 73%

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Vasoconstriction of Isolated Arteries Induced by Angiographic Contrast Media

Karstoft¹,

Bååth²,

Jansen³

et al. 1995

Acta Radiol

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Angiographic contrast media (CM) may cause both vasodilatation and vasoconstriction, effects that can only be partly be explained by the media's hyperosmolality. The present study describes a CM-induced vasoconstriction of isolated rabbit coronary arteries that depends on chemotoxicity and ion content of the CM. Rings of arteries were mounted in tissue baths and the constrictions induced by different CM were measured. Iotrolan and iodixanol (nonionic dimers) caused the most powerful constrictions followed by iohexol (non-ionic monomer) and mannitol. Ioxaglate (ionic dimer) and diatrizoate (ionic monomer) caused no or weak constrictions. By comparing these findings with previous studies, it is concluded that non-ionic media cause vasoconstriction due to depolarization of the smooth muscle cells, an effect that for iohexol can be counteracted by addition of 30 mM NaCI. The ionic media seem to cause hyperpolarization of the cells. This difference between nonionic and ionic CM might be one of the reasons for the lower tendency of non-ionic CM to cause vasodilatation clinically.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 73%

Vasoconstriction of Isolated Arteries Induced by Angiographic Contrast Media

Karstoft¹,

Bååth²,

Jansen³

et al. 1995

Acta Radiol

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Contrast Medium-Induced Vasoconstrictions

Karstoft¹,

Bååth²,

Jansen³

et al. 1995

Acta Radiol

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Angiographic contrast media (CM) may cause both vasodilatation and vasoconstriction. This study evaluates a contrast mediuminduced vasoconstriction that occurs when isolated arteries are exposed directly to a CM. Segments of rabbit coronary arteries were mounted in tissue baths containing buffer solution. During the experiments the buffer solution was exchanged with iohexol iso-osmolar with plasma, which caused a temporary vasoconstriction of the vessel segments. The constriction did not depend on the degree of oxygenation of iohexol. The endothelium was not involved in the vasoconstriction. Prazosin slightly decreased the vasoconstriction and a small part of the constriction might thus depend on liberation of norepinephrine by iohexol. The constriction was totally inhibited by the calcium antagonist nifedipine, while it was augmented by addition of low concentrations of KCI to ihoexol. It is concluded that the otherwise safe CM iohexol causes vasoconstriction in vitro by depolarizing the smooth muscle cells and the nerve terminals in the vessel wall.

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