Effects of vasoactive intestinal polypeptide on renal function in man.

Abstract

SUMMARY1. Six healthy males received vasoactive intestinal polypeptide (VIP; 6 pmol kg-' min-) by intravenous infusion for 90 min, with 60 min control periods before and after. Plasma VIP levels rose by about 100 pmol 1-1 during the infusion.2. VIP produced changes in heart rate and blood pressure consistent with generalized vasodilatation, but there were no significant changes in effective renal plasma flow or glomerular filtration rate.3. Both plasma solids and haematocrit rose by about 5 %, suggesting that haemoconcentration had occurred during VIP infusion.4. Urine flow fell to about a third, and the fractional excretion of sodium, potassium, chloride and calcium fell to between half and two-thirds of control values. Fractional excretion of phosphate did not fall significantly.5. Plasma renin activity rose about 3-fold during VIP infusion.

Vasoactive intestinal polypeptide regulation of rabbit renal adenylate cyclase activity in vitro.

“…It is primarily recognized for its actions on the gastrointestinal tract from where it was first isolated (see Mutt, 1982) and where it is probably involved in the control of intestinal secretion of salt and water (Krejs, 1982). Some data exist on the regulation of renal function by VIP, as infusions of VIP may affect renin release, renal haemodynamics and renal tubular function (Calam et al 1983;Dimaline et al 1983;Porter et al 1985;Rosa et al 1985). A physiological regulatory role for VIP upon renal function would require a response to either circulating plasma VIP, or to VIP released from nerve terminals present in the kidney.…”

“…Vasoactive intestinal peptide (VIP) has been implicated in the control of renal function in a variety of species, including man (Calam, Dimaline, Peart, Singh & Unwin, 1983;. Infusions of VIP are known to influence both renal haemodynamics and the release of renin (Porter & Ganong, 1982;PHY 387 N. M. GRIFFITHS AND N. L. SIMMONS Porter, Said & Ganong, 1983;Dimaline et al 1983;Porter, Thrasher, Said & Ganong, 1985).…”

Renal effects of gastrin C‐terminal tetrapeptide (as pentagastrin) and cholecystokinin octapeptide in conscious rabbit and man

“…Between 08 h 00 min and 08 h 30min an oral water load of 10mlkg-' was given; thereafter subjects drank water at a rate equal to their urine flow during the preceding 30 min. Sodium paraaminohippurate (PAH) infusion and endogenous creatinine clearance were used to estimate ERPF and GFR, respectively (Calam et al, 1983 Laboratory analyses ofptasma and urine Previously described techniques (Calam et al, 1983) were used to measure electrolytes, including calcium and phosphate, PAH, creatinine, PCV and plasma renin activity (PRA; by radioimmunoassay). CCK8-like immunoreactivity concentrations (CCK8-LI) were determined by radioimmunoassay using a Cterminal specific CCK/gastrin antibody (Calam et al, 1982 …”

Renal epithelial Cl‐ secretion

“…VIP and isoprenaline activate a similar pool of adenylate cyclase, perhaps in the intercalated cell population (Brick-Ghannam et al 1992). It should be noted that VIP promotes natriuresis in rabbits and man (Calam, Dimaline, Peart, Singh & Unwin, 1983;Duggan & MacDonald, 1987). In man and other mammals the patterns of segmentation are not distinct, with a gradual change in characteristics along the distal nephron; this is true for activation of adenylate cyclase by salmon calcitonin and PTH (Chabardes, Gagnan-Brunette, Imbert-Teboul, Gont-charevskaia, Montegut, Clique & Morel, 1980).…”