Effects of Vasoactive Intestinal Peptide on Human Sperm Motility

Siow, Yong; Stokes-Roussell, S; Cook, Carol A.; Si, Taylor; Lj, Goldsmith; Am, Belker; Sc, Yoffe; Me, Fallat

doi:10.1080/014850199262742

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Vasoactive intestinal peptide stimulates adenylyl cyclase activity, which elevates intracellular cAMP which in turn activates protein kinase [39]. There are speculations that directly increased synthesis of cAMP by stimulated adenylyl cyclase activity will ultimately lead to an increased sperm motility [40]. However, in our functional study of the different prostasome types, we found equal amounts of VIP in all three prostasome types and similar content of CD10 (enkephalinase) in SP and NP; still only SP and metastasis-derived prostasomes possessed the promotive effect on washed spermatozoa.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of human prostasomes isolated from three different sources

Carlsson

Nilsson²,

Larsson

et al. 2003

The Prostate

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Section: Discussionmentioning

confidence: 99%

Characteristics of human prostasomes isolated from three different sources

Carlsson

Nilsson²,

Larsson

et al. 2003

The Prostate

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“…VIP and its receptor are expressed in the testis and epididymis, which may be involved in spermatogenesis [39,40]. Siow et al [41] also proved that VIP stimulates the activity of adenylyl cyclase, improves the level of cyclic 3 ′ ,5 ′ -adenosine monophosphate (cAMP) in Leydig cells and activates protein kinase activity, stimulates sperm movement, and improves sperm vitality through cAMPmediated axonal protein phosphorylation. Moreover, VIP protects the testicular vascular system.…”

Section: The Protective Effect Of Gihmentioning

confidence: 99%

Testis–Gut-Reproduction Axis: The Key to Reproductive Health

Zou,

Chen,

et al. 2024

Andrologia

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Reproductive health is an important issue for humanity. In the context of the increasing incidence rate of male infertility, it is essential to find the factors that affect male reproductive health. Gastrointestinal health is closely related to reproductive health. Gastrointestinal hormones (GIH) and gut microbiota (GM), as important material foundations for gastrointestinal function, can promote or inhibit testicular reproductive function, including spermatogenesis, sperm maturation, androgen synthesis, and even broader male diseases such as sexual function, prostate cancer, etc. On the contrary, the functional health of the testes is also of great significance for the stability of gastrointestinal function. This review mainly discusses the important regulatory effects of GIH and GM on male reproductive function.

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