Effects of Various Aluminium Compounds Given Orally to Mice on Al Tissue Distribution and Tissue Concentrations of Essential Elements

Długaszek, Maria; Fiejka, M; Graczyk, Alfreda; Aleksandrowicz, J.; Slowikowska, M.G.

doi:10.1034/j.1600-0773.2000.d01-25.x

Cited by 21 publications

(5 citation statements)

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“…Hence, in a future study, internalization within sperm cells could be qualitatively studied by various microscopy techniques and quantitatively by ICP-AES to support this hypothesis. A study by Długaszek et al (2000) also showed varying concentrations of Al in tissues of mice gavaged with Al. Significant changes in mouse sperm parameters due to exposure to iron oxide NPs were also reported (Varzeghani et al, 2018).…”

Section: Discussionmentioning

confidence: 93%

Effect of low-dose exposure of aluminium oxide nanoparticles in Swiss albino mice: Histopathological changes and oxidative damage

Ghosh

Chakrabarti

et al. 2020

Toxicol Ind Health

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Rapid growth in the use of aluminium oxide nanoparticles (Al2O3 NPs) in various fields such as medicine, pharmacy, cosmetic industries, and engineering creates concerns since the literature is replete with data regarding their toxicity in living organisms. The objective of the present study was to demonstrate the potential toxicological manifestations of repeated exposure to Al2O3 NP at low doses in vivo. In the present study, Al2O3 NP was orally administered at 15, 30 or 60 mg kg−1 body weight for 5 days to Swiss albino male mice. A battery of well-defined assays was undertaken to evaluate aluminium (Al) bioaccumulation, haematological and histological changes, oxidative damage and genotoxicity. Physico-chemical characterisation demonstrated increases in hydrodynamic diameter along the concentration gradient of Al2O3 NP dispersed in MilliQ water. Brain, liver, spleen, kidney and testes showed high Al retention levels. Histopathological lesions were prominent in the brain and liver. Al2O3 NP treatment increased levels of lipid peroxidation and decreased glutathione content in the test organs at all dose levels. The enzyme activities of catalase and superoxide dismutase were also significantly altered. DNA damage quantified using the comet assay was markedly increased in all the soft organs studied. Anatomical abnormalities, redox imbalance and DNA damage were positively correlated with Al retention in the respective organs. Size, zeta potential and colloidal state might have contributed to the bio-physico-chemical interactions of the NPs in vivo and were responsible for the non-linear dose response. The overall data indicate that Al2O3 NP exposure may result in adverse health consequences, inclusive of but not limited to disturbed redox homeostasis, hepatocellular toxicity, neurodegeneration and DNA damage.

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Section: Discussionmentioning

confidence: 93%

Effect of low-dose exposure of aluminium oxide nanoparticles in Swiss albino mice: Histopathological changes and oxidative damage

Ghosh

Chakrabarti

et al. 2020

Toxicol Ind Health

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“…Panlab Domingo et al (1993) Essentially Al free Purified diet Fosmire et al (1993) Commercial rodent chow Fosmire et al (1993) 7 Dyets purified diet and Golub and Germann (2001) a Panlab Colomina et al (1998) Purina 5001C Oteiza et al (1993 Purified diet Oteiza et al (1993) 64.5 Commercial mouse chow Długaszek et al (2000) Purina 5001 rodent chow Guo et al (2001Guo et al ( , 2002Guo et al ( , 2005bGuo et al ( , 2006Guo et al ( , 2009 Gupta et al (1986) 8300 Purina Rodent Chow 5001 Fleming and Joshi (1987) Altromin 1320 Gawlik et al (1987) Sniff diet Gawlik et al (1987) 7.3 Altromin C Gawlik et al (1987) 66 Purina Certified 5002 rodent chow Hicks et al (1987) 60 Panlab Domingo et al (1987b) a Wayne Lab Blox Fulton et al (1989) and 135…”

Section: -280mentioning

confidence: 99%

Aluminum reproductive toxicity: a summary and interpretation of scientific reports

Yokel

2020

Critical Reviews in Toxicology

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Publications addressing aluminum (Al)-induced reproductive toxicity were reviewed. Key details were compiled in summary tables. Approximate systemic Al exposure, a measure of bioavailability, was calculated for each exposure, based on the Al percentage in the dosed Al species, Al bioavailability, and absorption time course reports for the exposure route. This was limited to laboratory animal studies because no controlled-exposure human studies were found. Intended Al exposure was compared to unintended dietary Al exposure. The considerable and variable Al content of laboratory animal diets creates uncertainty about reproductive function in the absence of Al. Aluminum-induced reproductive toxicity in female mice and rats was evident after exposure to !25-fold the amount of Al consumed in the diet. Generally, the additional daily Al systemic exposure of studies that reported statistically significant results was greater than 100-fold above the typical human daily Al dietary consumption equivalent. Male reproductive endpoints were significantly affected after exposure to lower levels of Al than females. Increased Al intake increased fetus, placenta, and testes Al concentrations, to a greater extent in the placenta than fetus, and, in some cases, more in the testes than placenta. An adverse outcome pathway (AOP) was constructed for males based on the results of the reviewed studies. The proposed AOP includes oxidative stress as the molecular initiating event and increased malondialdehyde, DNA and spermatozoal damage, and decreased blood testosterone and sperm count as subsequent key events. Recommendations for the design of future studies of reproductive outcomes following exposure to Al are provided.

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“…The Panel noted that most of the biochemical and toxicological studies did not measure the "normal" aluminium content of the basal diet fed to the animals, and therefore the stated dose in such studies is likely to be an underestimate of the total aluminium exposure. Thus, rat diets have been reported to contain 110 (Kandiah and Kies, 1994), 100 (Gupta et al, 1986), 5 (Glynn et al, 1995), and 51 mg aluminium/kg (Yokel et al, unpublished results cited by IAI, 2007), mouse diet to contain 131 and 64.5 mg aluminum/kg (Dlugaszek et al, 2000and Fosmire et al, 1993as cited by IAI, 2007, guinea pig diet to contain 47 (Golub et al, 1996a) and 60 mg aluminium/kg (Owen et al, 1994), and rabbit diet to contain 297, 1215 and 335 mg Al/kg (Fulton & Jeffery, 1990, Yokel and McNamara, 1985, and Yokel et al, unpublished results, as cited by IAI, 2007. As an example, for a rat diet containing aluminium at a concentration of 100 mg/kg, applying the default conversion factors indicates base-line doses of aluminium equivalent to 15 mg/kg bw for mice and 10 mg/kg bw for rats.…”

Section: Biological and Toxicological Datamentioning

confidence: 99%

“…The distribution of aluminium in animals after oral exposure has been determined in a number of studies (Cranmer et al, 1986;Deng et al, 2000;Dlugaszek et al, 2000;Domingo et al,. 1993;Greger and Donnaubauer 1986;Julka et al, 1996;Ogasawara et al, 2002;Sutherland and Greger 1998;Walton et al, 1995;Yokel and McNamara 1985;Zafar et al, 1997as cited by IAI, 2007.…”

Section: Animal Studiesmentioning

confidence: 99%

Safety of aluminium from dietary intake ‐ Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC)

2008

EFS2

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Following a request from the Commission, the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC) was asked to provide a scientific opinion on the safety of aluminium from all sources of dietary intake. In the event the estimated exposure for a particular sub-group(s) is found to exceed the Provisional Tolerable Weekly Intake, a detailed breakdown by exposure source should be provided. Aluminium occurs naturally in the environment and is also released due to anthropogenic activities such as mining and industrial uses, in the production of aluminium metal and other aluminium compounds. A variety of aluminium compounds are produced and used for different purposes, such as in water treatment, papermaking, fire retardant, fillers, food additives, colours and pharmaceuticals. Aluminium metal, mainly in the form of alloys with other metals, has many uses including in consumer appliances, food packaging and cookware. The major route of exposure to aluminium for the general population is through food. Aluminium in drinking water represents another, minor, source of exposure. Additional exposures may arise from the use of aluminium compounds in pharmaceuticals and consumer products. Most unprocessed foods typically contain less than 5 mg aluminium/kg. Higher concentrations (mean levels 5 to 10 mg/kg) were often found in breads, cakes and pastries (with biscuits having the highest levels), some vegetables (with mushrooms, spinach, radish, swiss card, 1 For citation purposes: Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials on a request from European Commission on Safety of aluminium from dietary intake.

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Effects of Various Aluminium Compounds Given Orally to Mice on Al Tissue Distribution and Tissue Concentrations of Essential Elements

Cited by 21 publications

References 0 publications

Effect of low-dose exposure of aluminium oxide nanoparticles in Swiss albino mice: Histopathological changes and oxidative damage

Effect of low-dose exposure of aluminium oxide nanoparticles in Swiss albino mice: Histopathological changes and oxidative damage

Aluminum reproductive toxicity: a summary and interpretation of scientific reports

Safety of aluminium from dietary intake ‐ Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC)

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