Effects of variants of 50 genes on diabetes risk among the Chinese population born in the early 1960s

Abstract

BackgroundGenome‐wide association studies have identified loci that significantly increase diabetes risk. This study explored the genetic susceptibility in relation to diabetes risk in adulthood among a Chinese population born in the early 1960s.MethodsIn all, 2129 subjects (833 males, 1296 females) were selected from the cross‐sectional 2010 to 2012 China National Nutrition and Health Survey. Fifty diabetes‐related single nucleotide polymorphisms (SNPs) were detected. Two diabetes genetic risk scores (GRSs) based on the 50 diabetes‐predisposing variants were developed to examine the association of these SNPs with diabetes risk.ResultsAssociations were found between diabetes risk and SNPs in the MTNR1B (rs10830963), KLHDC5 (rs10842994), GRK5 (rs10886471), cyclindependentkinase 5 regulatory subunit associated protein 1 (rs10946398), adaptorrelated protein complex 3 subunit sigma 2 (rs2028299), diacylglycerol kinase beta/transmembrane protein 195 (rs2191349), SREBF chaperone (rs4858889), ankyrin1 (rs516946), RAS guanyl releasing protein 1 (rs7403531), and zinc finger AN1‐type containing 3 (rs9470794) genes. As a continuous variable, with a 1‐point increase in the GRS or weighted (w) GRS, fasting plasma glucose (FPG) increased 0.045 and 0.044 mM, respectively (P < 0.001 for both), after adjusting for confounders. Both GRS and wGRS showed an association with diabetes, with a multivariable‐adjusted odds ratio (95% confidence interval) of 1.09 (1.00‐1.19) and 1.12 (1.03‐1.22), respectively, among all subjects. No significant associations were found between the GRS or wGRS and impaired fasting glucose or impaired glucose tolerance.ConclusionsThe data suggest the association of 10 SNPs and the GRS or wGRS with diabetes risk. Genetic susceptibility to diabetes may synergistically affect the risk of diabetes in adulthood.

The Association between CDKAL1 Gene rs10946398 Polymorphism and Post-Transplant Diabetes in Kidney Allograft Recipients Treated with Tacrolimus

“…PTDM occurs frequently after kidney transplantation and may be associated with graft loss, so factors that may increase the risk of this complication are being sought. Previous studies have shown that the pathophysiological changes leading to the development of PTDM are similar to those in type 2 diabetes mellitus [ 7 , 8 , 22 , 23 ]. It is believed that the risk factors leading to the occurrence of PTDM include factors associated with the development of type 2 diabetes mellitus, such as obesity, metabolic syndrome and a family history of type 2 diabetes mellitus.…”

“…Due to the similar pathogenesis of PTDM and type 2 diabetes, risk factors are currently being sought among the genetic polymorphisms associated with the development of type 2 diabetes [ 7 ]. Among them are polymorphisms in genes encoding enzymes involved in carbohydrate metabolism.…”

Need to establish a new adolescent suicide prevention programme in South Korea

“…50 Although several suicide prevention activities or strategies have been implemented, strategies proven effective in reducing suicide rates, such as early intervention for youth with mental health disorders, are often not available. Only through a comprehensive and in-depth investigation on the genetic architecture, biomarkers and comorbidities, can the high-risk population at pre-diagnostic or prodromal or asymptomatic stages be targeted, [51][52][53][54][55] and clinical patients can be classified 56 and be treated individually. 50 57 Currently, Korea has implemented a suicide report system with the information mainly provided by the teachers who have a suicidal student.…”

Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5

“… 7 , 8 , 9 GRK5 has been identified as a T2D susceptibility gene by genome-wide association study (GWAS). 10 , 11 , 12 , 13 , 14 A variant of GRK5 is associated with the therapeutic efficacy of insulin secretagogue, repaglinide, in those with T2D, 15 and with plasma LDL-cholesterol levels. 16 Germline Grk5 knockout mice displayed mildly impaired glucose tolerance.…”