Effects of Varenicline on Smoking Cessation in Adults With Stably Treated Current or Past Major Depression

Abstract

Pfizer.

Varenicline and Adverse Cardiovascular Events: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

“…After the removal of duplicates and screening of titles and abstracts, 68 trials underwent full‐text review. In total, 38 RCTs met all eligibility criteria and were included in our meta‐analysis 10, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49…”

Smoking and common mental disorders in patients with chronic conditions: An analysis of data collected via a web-based screening system

“…[8] Evidence suggests that smoking cessation interventions can be effective are no less effective in smokers with common mental disorders. [9] A recent multicentre randomised controlled trial examining the impact of varenicline on smoking cessation rates in adults with stable current or past major depressive disorder has shown increased cessation with no adverse effects on symptoms of depression or anxiety. [9] Furthermore, staged intervention incorporating motivational feedback and psychological counselling can be effective for enhancing cessation in mental health outpatients.…”

“…[9] A recent multicentre randomised controlled trial examining the impact of varenicline on smoking cessation rates in adults with stable current or past major depressive disorder has shown increased cessation with no adverse effects on symptoms of depression or anxiety. [9] Furthermore, staged intervention incorporating motivational feedback and psychological counselling can be effective for enhancing cessation in mental health outpatients. [10] Analysis of a randomised controlled trial examining the impact of counselling combined with Nicotine Replacement Therapy has also demonstrated no adverse mental health outcomes after quitting smoking in patients with clinical depression [11] and meta-analysis evidence suggests that cessation may reduce symptoms of depression and anxiety [12].…”

Efficacy of Varenicline for Smoking Cessation in Bipolar Disorder

“…That would be a take-away message suggested by another recent multisite randomized comparison of varenicline or placebo in over 500 remitted major depression patients whose mood disorder had been stabilized before starting varenicline. 10 Wise management may thus point to a sequence of clinical events: identify and treat mood disorders in known or at-risk patients, and then consider varenicline as a safe and effective adjunctive treatment option for patients who smoke.…”