Effects of vanillin on potassium bromate-induced neurotoxicity in adult mice: impact on behavior, oxidative stress, genes expression, inflammation and fatty acid composition

Saad, Hajer Ben; Kharrat, Nadia; Driss, Dorra; Marrakchi, Rim; Jammoussi, Kamel; Magné, Christian; Boudawara, Tahia; Chaabouni, Samia Ellouz; Zeghal, Khaled Mounir; Hakim, Ahmed; Amara, Ibtissem Ben

doi:10.1080/13813455.2017.1283527

Cited by 22 publications

(14 citation statements)

References 48 publications

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“…8 Recently, vanillin has been found to display a significant brain protective property through its antioxidant and anti-inflammatory activities. 9 Vanillin biological properties are mainly ascribed to its phenolic compounds, ether and aldehyde moieties. 6 It is used against oxidative damage induced by several xenobiotics like pesticides.…”

Section: Introductionmentioning

confidence: 99%

Beneficial role of vanillin, a polyphenolic flavoring agent, on maneb-induced oxidative stress, DNA damage, and liver histological changes in Swiss albino mice

et al. 2019

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Vanillin, a widely used flavoring agent, has antimutagenic and antioxidant properties. The current study was performed to evaluate its beneficial role against hepatotoxicity induced by maneb, a dithiocarbamate fungicide. Mice were divided into four groups of six each: group 1, serving as negative controls which received by intraperitoneal way only distilled water, a solvent of maneb; group 2, received daily, by intraperitoneal way, maneb (30 mg kg−1 body weight (BW)); group 3, received maneb at the same dose of group 2 and 50 mg kg−1 BW of vanillin by intraperitoneal way; and group 4, serving as positive controls, received daily only vanillin. After 10 days of treatment, mice of all groups were killed. Our results showed that vanillin significantly reduced the elevated hepatic levels of malondialdehyde, hydrogen peroxide, and advanced oxidation protein product and attenuated DNA fragmentation induced by maneb. In addition, vanillin modulated the alterations of antioxidant status: enzymatic (superoxide dismutase, catalase, and glutathione peroxidase) and nonenzymatic (reduced glutathione, nonprotein thiol, and vitamin C) antioxidants in the liver of maneb-treated mice. This natural compound was also able to ameliorate plasma biochemical parameters (aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transpeptidase, alkaline phosphatase, total bilirubin, and total protein). The protective effect of vanillin was further evident through the histopathological changes produced by maneb in the liver tissue. Thus, we concluded that vanillin might be beneficial against maneb-induced hepatic damage in mice.

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Section: Introductionmentioning

confidence: 99%

Beneficial role of vanillin, a polyphenolic flavoring agent, on maneb-induced oxidative stress, DNA damage, and liver histological changes in Swiss albino mice

et al. 2019

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“…Accordingly, they stated that KBrO 3 induced depression‐like behaviors and caused oxidative stress. [ 30 ] Dhouibi et al [ 31 ] examined neurobehavioral changes induced by chronic exposure to KBrO 3 in rats and reported that exposure to KBrO 3 caused a reduction in SOD and CAT enzyme activity levels. In another study, where the effects of KBrO 3 administration on the brain functions and behaviors of albino mice were investigated, it was shown that KBrO 3 had severely harmful effects on the central nervous system, and for this reason, its usage should be avoided.…”

Section: Discussionmentioning

confidence: 99%

The protective effect of arbutin against potassium bromate‐induced oxidative damage in the rat brain

Akkoyun

Uyar

Akkoyun

et al. 2022

J Biochem & Molecular Tox

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This study aimed to investigate the protective effects of arbutin (ARB) against brain injury induced in rats with potassium bromate (KBrO3). The rats were divided into four groups as Group 1: Control (0.9% NaCl ml/kg/day p.), Group 2: KBrO3 (100 mg/kg (gavage), Group 3: ARB (50 mg/kg/day p.), and Group 4: KBrO3 + ARB (100 mg/kg (gavage) + 50 mg/kg/day p.). At the end of the fifth day of the study, the rats in all groups were killed, and their brain tissues were collected. In the collected brain tissues, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) levels were measured, and routine histopathological examinations were made. The MDA levels in the group that was exposed to KBrO3 were significantly higher than those in the control group (p ˂ 0.001). In comparison to the KBrO3 group, the MDA levels in the KBrO3 + ARB group were significantly lower (p ˂ 0.001). It was observed that SOD and CAT enzyme activity levels were significantly lower in the KBrO3 group compared to the control group (p ˂ 0.001), while these levels were significantly higher in the KBrO3 + ARB group than in the KBrO3 group (p ˂ 0.001). Additionally, the group that was subjected to KBrO3 toxicity, as well as ARB administration, had much lower levels of histopathologic signs than the group that was subjected to KBrO3 toxicity only. Consequently, it was found that KBrO3 exposure led to injury in the brain tissues of the rats, and using ARB was effective in preventing this injury.

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“…counteracted chemically induced brain toxicity due to exposure to such agents as ethanol, carbon tetrachloride, and potassium bromate (KBrO 3 ). [66][67][68] Compared with controls, vanillin dosing was associated with decreased lipid peroxidation, oxidative stress, and generation of inflammatory cytokines in the brain. Two studies reported that vanillin (286 mg/kg, i.p.)…”

Section: Antisickling Actionmentioning

confidence: 99%

Vanilla

2023

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Effects of vanillin on potassium bromate-induced neurotoxicity in adult mice: impact on behavior, oxidative stress, genes expression, inflammation and fatty acid composition

Abstract: This work suggests that vanillin mitigates KBrO-induced depression, and that this neuroprotective effect proceeds through anti-oxidant and anti-inflammatory activities.

Cited by 22 publications

References 48 publications

Beneficial role of vanillin, a polyphenolic flavoring agent, on maneb-induced oxidative stress, DNA damage, and liver histological changes in Swiss albino mice

Beneficial role of vanillin, a polyphenolic flavoring agent, on maneb-induced oxidative stress, DNA damage, and liver histological changes in Swiss albino mice

The protective effect of arbutin against potassium bromate‐induced oxidative damage in the rat brain

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