Effects of vagal stimulation on cesium-induced early afterdepolarizations and ventricular arrhythmias in rabbits.

Takahashi, Naohiko; Ishida, Shiro; Fujino, Takao; Nakagawa, Mikiko; Ito, Morio; Saikawa, Tetsunori; Arita, Makoto

doi:10.5105/jse.13.141

Cited by 6 publications

(13 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 A bipolar catheter (3Fr) consisting of a silver-silver chloride electrode with a reference electrode 5 mm from the proximal electrode was introduced through a small stab wound in the left ventricular free wall. The electrode tip was placed on the anterior left ventricular endocardium close to the apical portion of the septum.…”

Section: Map Recordingsmentioning

confidence: 99%

“…12 We have shown that vagal stimulation decreases the amplitude of Cs-induced EADs and suppresses the development of PVT. 6 All of these studies emphasize the importance of the autonomic nervous system in the pathogenesis of ventricular arrhythmias in the setting of QT interval prolongation.…”

mentioning

confidence: 99%

“…1 In animal experiments, intravenous cesium chloride (Cs) administration produces EADs in the ventricular monophasic action potentials (MAPs) and causes both prolongation of the QT interval and polymorphic ventricular tachycardias (PVTs) resembling torsade de pointes. [2][3][4][5][6][7] The electrocardiographic changes and ventricular arrhythmias induced by Cs are considered to represent an experimental animal model of the long QT syndrome. [2][3][4] Torsade de pointes associated with the long QT syndrome is often elicited by sudden increases in sympathetic activity 8 and can be suppressed by -adrenergic blocking agents 9 or by ablation of the left stellate ganglion.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Baroreflex Sensitivity Predicts the Induction of Ventricular Arrhythmias by Cesium Chloride in Rabbits

Ou¹,

Nakagawa²,

Yonemochi³

et al. 1999

Jpn Circ J

Self Cite

View full text Add to dashboard Cite

Section: Map Recordingsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Baroreflex Sensitivity Predicts the Induction of Ventricular Arrhythmias by Cesium Chloride in Rabbits

Ou¹,

Nakagawa²,

Yonemochi³

et al. 1999

Jpn Circ J

Self Cite

View full text Add to dashboard Cite

“…22,23) Among a number of pharmacological interventions associated with triggered firing, cesium chloride (an inhibitor of funny inward current, transient outward current, inward rectifier currents, and delayed rectifier K+ currents) reproducibly induces VTs and has been used to investigate electrophysiological profiles of VTs caused by abnormal ventricular repolarization in experimental studies. 25,26) In a previous study using beating canine hearts, we attempted to determine whether the source of these VTs is limited to subendocardial Purkinje network or not. 27) In Figure 6, isochronal maps of an episode of polymorphic VT with relatively narrow QRS.…”

Section: Cesium-induced Polymorphic Vtmentioning

confidence: 99%

Focal and Reentrant Mechanisms of Torsades de Pointes: EAD, Reentry, or Chimera?

Murakawa

2011

J Arrhythmia

View full text Add to dashboard Cite

Torsades de pointes (TdP) is characterized not only by its electrocardiographic morphology but also by a tendency to spontaneously terminate. Although clinical and experimental studies suggested that TdP is triggered exclusively by early afterdepolarization, the reentrant mechanism seems to play a certain role in its maintenance. In this article, I review the studies that investigated the origin and activation sequences of the twisting QRS complexes of TdP, and discuss whether it is fortunate or unfortunate for us if TdP has something to do with reentry. (J Arrhythmia 2011; 27: 28-37)

show abstract

“…3,8) To accomplish this, the right cervical vagus nerve was carefully isolated and then stimulated with square pulses (2 ms duration at 50 Hz) delivered by an electronic stimulator (SEC-7203, Nihon Kohden).…”

Section: In Vitro Experimentsmentioning

confidence: 99%

Preceding Stimulus Frequency-Dependent Potentiation of the Postrest Shortening of the Action Potential Duration in Rabbits.

Takahashi¹,

Ito²,

Ishida³

et al. 2000

Jpn Heart J

Self Cite

View full text Add to dashboard Cite

SUMMARYAction potential duration (APD) in rabbit ventricular myocardium shortens after a rest period (postrest shortening). However, the effects of preceding stimulus frequency on the postrest shortening have not been elucidated. We recorded transmembrane action potentials (TAPs) and monophasic action potentials (MAPs) from the rabbit ventricle. In in vitro experiments, repetitive regular stimuli (S1) at cycle lengths ranging between 500 to 3000 ms were followed by a single extrastimulus (S2) at a coupling interval of 5000 ms. A decrease in S1S1 interval resulted in a progressive shortening of the duration of TAP (TAPD) elicited by S2 (S2-TAPD), which was potentiated by increasing extracellular calcium concentration ([Ca 2+ ] o ) or application of ouabain and was inhibited by lowering [Ca 2+ ] o or verapamil. Application of ryanodine was most effective in lengthening S2-TAPD following a short S1S1 interval. 4-aminopyridine and E4031 caused marked lengthening of S2-TAPD when S1S1 was long. However, the lengthening effect was attenuated and disappeared with a shorter S1S1 interval. In in vivo experiments, regular ventricular pacing (S1) at cycle lengths ranging between 250 to 1000 ms was followed by a single extrastimulus (S2) with a coupling interval (S1S2) of 1500 ms. A decrease in the S1S1 interval also resulted in progressive shortening of the duration of MAP elicited by S2. Our results indicate that the postrest shortening is potentiated by an increase in the preceding stimulus frequency in the rabbit ventricle, in which the function of sarcoplasmic reticulum may play a significant role. (Jpn Heart J 2000; 41: 481-492)

show abstract

Effects of vagal stimulation on cesium-induced early afterdepolarizations and ventricular arrhythmias in rabbits.

Cited by 6 publications

References 12 publications

Baroreflex Sensitivity Predicts the Induction of Ventricular Arrhythmias by Cesium Chloride in Rabbits

Baroreflex Sensitivity Predicts the Induction of Ventricular Arrhythmias by Cesium Chloride in Rabbits

Focal and Reentrant Mechanisms of Torsades de Pointes: EAD, Reentry, or Chimera?

Preceding Stimulus Frequency-Dependent Potentiation of the Postrest Shortening of the Action Potential Duration in Rabbits.

Contact Info

Product

Resources

About