Effects of vaccination, new SARS-CoV-2 variants and reinfections on post-COVID-19 complications

Orendáčová, Mária; Kvašňák, Eugen

doi:10.3389/fpubh.2022.903568

Cited by 5 publications

(10 citation statements)

References 154 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That’s why, it is hypothesized that COVID-19 vaccination might help reset the immune system, reduce the exaggerated inflammatory response, and eradicate the viral reservoir [ 19 ]. Another theory is the proven significant prevention of complications caused by secondary pathological processes related to SARS-CoV2 infection itself, e.g., organ/systemic derangements, depression, and anxiety disorders [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Neuropsychiatric post-acute sequelae of COVID-19: prevalence, severity, and impact of vaccination

Elmazny

Magdy

Hussein

et al. 2023

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

The potential long-term neuropsychiatric effects of COVID-19 are of global concern. This study aimed to determine the prevalence and predictors of neuropsychiatric post-acute sequelae of COVID-19 among Egyptian COVID-19 survivors and to study the impact of full vaccination before COVID-19 infection on the occurrence and severity of these manifestations. Three months after getting COVID-19 infection, 1638 COVID-19 survivors were screened by phone for possible neuropsychiatric sequelae. Subjects suspected to suffer from these sequelae were invited to a face-to-face interview for objective evaluation. They were requested to rate the severity of their symptoms using visual analogue scales (VAS). The mean age of participants was 38.28 ± 13 years. Only 18.6% were fully vaccinated before COVID-19 infection. Neuropsychiatric post-acute sequelae of COVID-19 were documented in 598 (36.5%) subjects, fatigue was the most frequent one (24.6%), followed by insomnia (16.4%), depression (15.3%), and anxiety (14.4%). Moderate and severe COVID-19 infection and non-vaccination increased the odds of developing post-COVID-19 neuropsychiatric manifestations by 2 times (OR 1.95, 95% CI = 1.415–2.683), 3.86 times (OR 3.86, 95% CI = 2.358–6.329), and 1.67 times (OR 1.67, 95% CI = 1.253–2.216), respectively. Fully vaccinated subjects before COVID-19 infection ( n = 304) had significantly lesser severity of post-COVID-19 fatigue, ageusia/hypogeusia, dizziness, tinnitus, and insomnia ( P value = 0.001, 0.008, < 0.001, 0.025, and 0.005, respectively) than non-vaccinated subjects. This report declared neuropsychiatric sequelae in 36.5% of Egyptian COVID-19 survivors, fatigue being the most prevalent. The effectiveness of COVID-19 vaccines in reducing the severity of some post-COVID-19 neuropsychiatric manifestations may improve general vaccine acceptance.

show abstract

Section: Discussionmentioning

confidence: 99%

Neuropsychiatric post-acute sequelae of COVID-19: prevalence, severity, and impact of vaccination

Elmazny

Magdy

Hussein

et al. 2023

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

show abstract

“…Some specific host and viral risk factors potentially associated with increased chances of long COVID after SARS-CoV-2 reinfections [ 58 , 59 , 60 , 61 , 62 , 63 ] are summarized in Table 1 .…”

Section: Sars-cov-2 Reinfections and Long Covidmentioning

confidence: 99%

“…Further follow-up studies using the established case definition and precise diagnostic criteria for long COVID in people with or without reinfection, in both vaccinated and unvaccinated cohorts, may help to better understand the contribution of SARS-CoV-2 reinfections to long COVID burden. Moreover, prospective cohort studies with long observational periods for patients who experienced reinfections during different pandemic waves would be helpful to follow the evolution of long COVID [ 62 ].…”

Section: Sars-cov-2 Reinfections and Long Covidmentioning

confidence: 99%

SARS-CoV-2 Reinfections and Long COVID in the Post-Omicron Phase of the Pandemic

Boufidou,

Medić,

Lampropoulou

et al. 2023

IJMS

View full text Add to dashboard Cite

We are reviewing the current state of knowledge on the virological and immunological correlates of long COVID, focusing on recent evidence for the possible association between the increasing number of SARS-CoV-2 reinfections and the parallel pandemic of long COVID. The severity of reinfections largely depends on the severity of the initial episode; in turn, this is determined both by a combination of genetic factors, particularly related to the innate immune response, and by the pathogenicity of the specific variant, especially its ability to infect and induce syncytia formation at the lower respiratory tract. The cumulative risk of long COVID as well as of various cardiac, pulmonary, or neurological complications increases proportionally to the number of SARS-CoV-2 infections, primarily in the elderly. Therefore, the number of long COVID cases is expected to remain high in the future. Reinfections apparently increase the likelihood of long COVID, but less so if they are mild or asymptomatic as in children and adolescents. Strategies to prevent SARS-CoV-2 reinfections are urgently needed, primarily among older adults who have a higher burden of comorbidities. Follow-up studies using an established case definition and precise diagnostic criteria of long COVID in people with or without reinfection may further elucidate the contribution of SARS-CoV-2 reinfections to the long COVID burden. Although accumulating evidence supports vaccination, both before and after the SARS-CoV-2 infection, as a preventive strategy to reduce the risk of long COVID, more robust comparative observational studies, including randomized trials, are needed to provide conclusive evidence of the effectiveness of vaccination in preventing or mitigating long COVID in all age groups. Thankfully, answers not only on the prevention, but also on treatment options and rates of recovery from long COVID are gradually starting to emerge.

show abstract

“…A higher probability of persistent symptoms in the general population are associated with being women, older age, obesity, smoking or vaping, hospitalization, admitted to intensive care, and deprivation 6 , 21 . In addition, vaccination status and COVID-19 reinfection may be associated with post-COVID complaints 22 – 25 . In that, vaccinated against COVID-19 was associated with decreasing in post-COVID complaints by reducing risk of reinfection and providing additional immunological protection 23 – 26 .…”

Section: Introductionmentioning

confidence: 99%

Impairments following COVID-19 infection: manifestations and investigations of related factors

Badinlou

Forsström

Jansson‐Fröjmark

et al. 2023

Sci Rep

View full text Add to dashboard Cite

The COVID-19 pandemic had a major global impact on the health and wellbeing for many individuals. Even though the infection rates have gone down due to the availability of vaccines, the consequences of the disease are still present due to persistent symptoms among individuals. The aim of the current study was to map long‐term impairments in individuals infected with COVID-19 by applying the framework of the World Health Organization’s International Classification of Functioning, Disability and Health (ICF) and also investigate the factors related to the context of an individual’s life influencing the impairments. A web-survey that targeted individuals that had been infected with COVID-19 was used. The survey included a range of measures covering contextual factors and factors related to body functions and structures and post-COVID impairments. A total of 501 individuals were included in the study (with a mean age of 47.6 years). 96% of the respondents reported at least one moderate-to-severe impairment due to COVID-19 infection and the most frequent one was fatigue. In that, 79.6% and 86.9% of the study sample reported moderate-to-severe brain fatigue and tiredness or lack of energy, respectively. Severity of COVID-19 infection appeared as the strongest risk factor for post-COVID impairments. Based on the results, interventions can be tailored to help individuals with post-COVID-19 condition. This could be one way lessening the effect of COVID-19 on health care and society as a whole.

show abstract

Effects of vaccination, new SARS-CoV-2 variants and reinfections on post-COVID-19 complications

Cited by 5 publications

References 154 publications

Neuropsychiatric post-acute sequelae of COVID-19: prevalence, severity, and impact of vaccination

Neuropsychiatric post-acute sequelae of COVID-19: prevalence, severity, and impact of vaccination

SARS-CoV-2 Reinfections and Long COVID in the Post-Omicron Phase of the Pandemic

Impairments following COVID-19 infection: manifestations and investigations of related factors

Contact Info

Product

Resources

About