Effects of vaccination against COVID-19 on the evolution of critically ill patients

Varas, G. Morales; Casado, Marcelino Sánchez; Peinado, R. Padilla; Gallego, F. Morán; Vicente, M. Buj; Villamizar, A. Rodríguez

doi:10.1016/j.medine.2022.06.017

Cited by 1 publication

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As in previous studies, we found that vaccinated patients were older and had more comorbidities, 13 - 16 probably because older individuals with comorbidities constitute the main target of vaccination campaigns. In the unvaccinated group, we found a higher proportion of patients with severe ARF (PaO 2 /FiO 2 < 100 mmHg) at ICU admission, as well as increased levels of LDH and D-dimer, which are parameters related to worse clinical prognosis.…”

Section: Discussionsupporting

confidence: 82%

“…In a small study conducted in 2021, Morales et al showed no significant differences in length of stay or mortality between fully vaccinated, partially vaccinated, and unvaccinated patients. 13 Grapsa et al analyzed patients with ARDS caused by COVID-19 and the need for invasive mechanical ventilation, finding lower mortality in patients with complete vaccination than in controls who were either unvaccinated or partially vaccinated. 14 Graselli et al showed that although vaccination decreased the risk of ICU admission, vaccination status was not related to ICU or in-hospital mortality in patients admitted to the ICU.…”

Section: Discussionmentioning

confidence: 99%

“… 14 In a study conducted in an ICU in Spain, full vaccination was associated with fewer complications and lower mortality, although the differences were not significant. 13 In contrast, no difference in mortality was found between vaccinated and unvaccinated patients in multicenter studies conducted in Italy 15 and in Australia. 16 All of the aforementioned studies were conducted between June of 2021 and February of 2022, when the predominant SARS-CoV-2 variants were the Delta and then the Omicron.…”

Section: Introductionmentioning

confidence: 96%

“…Several studies have analyzed the outcomes of ICU patients on the basis of their vaccination status, but the results are conflicting. 13 - 16 In a multicenter study conducted in Greece and involving 256 patients with ARDS, mortality was found to be lower in fully vaccinated individuals. 14 In a study conducted in an ICU in Spain, full vaccination was associated with fewer complications and lower mortality, although the differences were not significant.…”

Section: Introductionmentioning

confidence: 99%

“…Vários estudos analisaram os desfechos de pacientes internados na UTI com base na situação vacinal, mas os resultados são conflitantes. (13)(14)(15)(16) Em um estudo multicêntrico realizado na Grécia com 256 pacientes com SDRA, a mortalidade foi menor em indivíduos com vacinação completa. (14) Em um estudo realizado em uma UTI na Espanha, a vacinação completa relacionou-se com menos complicações e menor mortalidade, embora as diferenças não tenham sido significativas.…”

Section: Introductionunclassified

See 4 more Smart Citations

Vaccination status and outcomes in critical COVID-19 patients

Nogueira Costa1,

Oliveira Pereira1,

Higon Cañigral2

et al. 2024

J Bras Pneumol.

View full text Add to dashboard Cite

Objective: To analyze the clinical characteristics and outcomes of patients with COVID-19-related acute respiratory failure on the basis of their vaccination status at the time of ICU admission. Methods: We conducted a retrospective observational study using a prospective database of patients admitted to the ICU of a university hospital in the city of Murcia, in Spain, between January 1, 2021 and September 1, 2022. Clinical, analytical, and sociodemographic data were collected and analyzed on the basis of patient vaccination status. We adjusted for confounding variables using propensity score matching and calculated adjusted ORs and 95% CIs. Results: A total of 276 patients were included in the study. Of those, 8.3% were fully vaccinated, 12% were partially vaccinated, and 79.7% were unvaccinated. Although fully vaccinated patients had more comorbidities, partially vaccinated patients had higher disease severity. The proportion of patients with severe acute respiratory failure was higher in the unvaccinated group, followed by the partially vaccinated group. No significant differences were found among the different groups regarding complications, duration of ventilatory support, or length of ICU/hospital stay. In the sample selected by propensity score matching, the number of patients with severe complications and the in-hospital mortality rate were higher in unvaccinated patients, but the differences were not significant. Conclusions: This study failed to show a significant improvement in outcomes in critically ill COVID-19 patients vaccinated against SARS-CoV-2. However, the CIs were wide and the mortality point estimates favored patients who received at least one dose of COVID-19 vaccine.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%