Effects of Urtica dioica on hepatic ischemia-reperfusion injury in rats

Abstract

OBJECTIVES:To evaluate the effects of Urtica dioica on hepatic ischemia‐reperfusion injury.METHODS:Thirty adult male Wistar albino rats were divided into three groups: sham group (group 1), control group (group 2), and Urtica dioica group (group 3). All the rats were exposed to hepatic ischemia for 60 min, followed by 60 min of reperfusion. In group 2, a total of 2 ml/kg 0.9% saline solution was given intraperitoneally. In group 3, a total of 2 ml/kg Urtica dioica was given intraperitoneally. At the end of the procedure, liver tissue and blood samples were taken from all rats. Serum aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, ceruloplasmin, catalase, paraoxonase, arylesterase, and lipid hydroperoxide levels were measured. Liver tissue histopathologies were also evaluated by light microscopy.RESULTS:Serum aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase levels were significantly higher in group 2 than in group 1, and significantly lower in group 3 than in group 2. Also, group 2 had higher serum lipid hydroperoxides and ceruloplasmin levels but lower catalase, paraoxonase, and arylesterase levels than group 1.In group 3, serum lipid hydroperoxides and ceruloplasmin levels were significantly lower, and catalase, paraoxonase, and arylesterase levels were higher than those in group 2. Histopathological examination showed that liver tissue damage was significantly decreased in group 3 compared with group 2.CONCLUSIONS:Urtica dioica has a protective effect on the liver in hepatic ischemia‐reperfusion‐injured rats.

The in vitro anti-viral potential of Setarud (IMOD™), a commercial herbal medicine with protective activity against acquired immune deficiency syndrome in clinical trials

“…[27] Another constituent of IMOD ( Urtica dioica ) has been used for treatment of various ailments in folk medicine. [2829] Leaves of this plant showed anti-inflammatory[30] and cell proliferative[31] effects in previous studies. Considering the biological activity of each composition of Setarud the effect of this medicine on cellular proliferation was studied here.…”

The Ameliorative Effects of Pycnogenol^® on Liver Ischemia-Reperfusion Injury in Rats

“…45 Tüfek et al 46 (2013) demonstrated that the serum, liver, lung, and kidney tissues of the IR group had higher TOS values and lower TAC values when compared with the sham group. When dexmedetomidine, an antioxidant compound, was administered to the IR group, it was observed that TOS values decreased and TAC values increased.…”

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“…The leaves extract of plant shows maximum hepatoprotective activity at dose of 400 mg/kg concluded by the decreased level of serum alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin level and malonyldehyde (MDA) and also by the increase in level of superoxide dismutase (SOD) level 67,68 . The seed extract of Urtica dioica has also shown hepoatoprotective protective activity against ischemia-reperfusion induced hepatotoxicity and it exhibited hepatoprotective effect by increasing the activity of paraoxonase, aryl-esterase and liver tissue catalase activity 69 .The plant extract has shown significant hepatoprotective effect in isolated rat hepatocytes (in vitro) and in rabbits (in vivo) reduces the chances of hepatocellular degeneration and necrotic changes in CCl 4 induced hepatotoxicity 70,71,72 .…”