2001
DOI: 10.1053/gast.2001.25542
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Effects of Ursodeoxycholic and Cholic Acid Feeding on Hepatocellular Transporter Expression in Mouse Liver

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Cited by 251 publications
(211 citation statements)
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“…34 TUDCA is known to stimulate the expression of transporter proteins and their targeting and insertion into the canalicular membrane for biliary secretion in the liver. 20,21 In our study, treatment with TUDCA reverted Mrp2 protein expression to basal levels in obstructed animals. Remarkably, the inhibition of NO synthesis by treating the rats with SMT also caused a recovery in liver Mrp2 protein levels.…”
Section: Protein S-nitrosation During Cholestasissupporting
confidence: 57%
See 1 more Smart Citation
“…34 TUDCA is known to stimulate the expression of transporter proteins and their targeting and insertion into the canalicular membrane for biliary secretion in the liver. 20,21 In our study, treatment with TUDCA reverted Mrp2 protein expression to basal levels in obstructed animals. Remarkably, the inhibition of NO synthesis by treating the rats with SMT also caused a recovery in liver Mrp2 protein levels.…”
Section: Protein S-nitrosation During Cholestasissupporting
confidence: 57%
“…18,19 Taurine-conjugated ursodeoxycholic acid (TUDCA) is known to protect hepatocytes in cholestasis by stimulating the expression and membrane insertion of transporter proteins. 20,21 Therefore, we treated BDL rats with SMT, and TUDCA was used as the clinical comparator in these studies. Our results suggest that the inhibition of NO synthesis during induced cholestasis ameliorates hepatocellular injury, and that this therapeutic effect is in part mediated by the improvement of liver proficiency in maintaining SNO homeostasis.…”
mentioning
confidence: 99%
“…In addition, it has been shown to stimulate canalicular transport and biliary excretion enhancing bile flow and reducing the exposure time of biliary epithelium to toxic bile salts. 34 However, its choleretic action also increases biliary pressure, which has been shown to aggravate bile infarcts and hepatocyte necrosis in the homozygous Mdr2Ϫ/Ϫ mice. 15 Moreover, ursodeoxycholic acid also displays a toxic character, affecting mitochondrial activity.…”
Section: Discussionmentioning
confidence: 99%
“…The transcriptional regulation of canalicular transporter proteins by UDCA and cholic acid (CA) has recently been addressed. 23 In hepatocytes of mice fed a UDCA-or CAsupplemented diet, both UDCA and CA up-regulated Bsep and Mrp2 mRNA. Since this effect was not specific for UDCA, its role for the anticholestatic action of UDCA remains unclear.…”
Section: Stimulation Of Hepatobiliary Secretionmentioning
confidence: 96%