Effects of urinary of organophosphate metabolites on nerve conduction and neurobehavioral performance among farmers in northern Thailand

Thammachai, Ajchamon; Sapbamrer, Ratana; Rohitrattana, Juthasiri; Tongprasert, Siam; Hongsibsong, Surat; Wangsan, Kampanat

doi:10.1007/s11356-022-24955-w

Cited by 3 publications

(3 citation statements)

References 49 publications

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“…Various epidemiological studies have demonstrated that a single acute exposure or repeated subclinical doses of OPs can result in delayed neuronal damage, which often continues for weeks to years after exposure, with neurological and neurobehavioral abnormalities [ 37 , 38 ]. Traditional antidotes are insufficient to prevent the development of neuronal damage due to poor BBB permeability [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Brain-targeted nanoreactors prevent the development of organophosphate-induced delayed neurological damage

Zou,

Wang,

et al. 2023

J Nanobiotechnol

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Background Organophosphate (OP)-induced delayed neurological damage is attributed to permanent neuropathological lesions caused by irreversible OP-neurocyte interactions, without potent brain-targeted etiological antidotes to date. The development of alternative therapies to achieve intracerebral OP detoxification is urgently needed. Methods We designed a brain-targeted nanoreactor by integrating enzyme immobilization and biomimetic membrane camouflaging protocols with careful characterization, and then examined its blood–brain barrier (BBB) permeability both in vitro and in vivo. Subsequently, the oxidative stress parameters, neuroinflammatory factors, apoptotic proteins and histopathological changes were measured and neurobehavioral tests were performed. Results The well-characterized nanoreactors exerted favourable BBB penetration capability both in vitro and in vivo, significantly inhibiting OP-induced intracerebral damage. At the cellular and tissue levels, nanoreactors obviously blocked oxidative stress, cellular apoptosis, inflammatory reactions and brain histopathological damage. Furthermore, nanoreactors radically prevented the occurrence of OP-induced delayed cognitive deficits and psychiatric abnormality. Conclusion The nanoreactors significantly prevented the development of OP-induced delayed neurological damage, suggesting a potential brain-targeted etiological strategy to attenuate OP-related delayed neurological and neurobehavioral disorders. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Brain-targeted nanoreactors prevent the development of organophosphate-induced delayed neurological damage

Zou,

Wang,

et al. 2023

J Nanobiotechnol

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“…Paparan pestisida yang tinggi juga dapat menyebabkan terjadinya terganggunya perkembangan saraf, serta gangguan perilaku para remaja, demensia gangguan defisit perhatian, perubahan perilaku ke arah yang negatif [14] [15]. Pestisida juga dapat menurunkan konduksi saraf dan kinerja neurobehavioral pada para petani, seperti yang terjadi pada para petani di Thailand Utara di mana pestisida yang digunakan yaitu pestisida jenis organofosfat [16].…”

Section: Penyakit Saraf Dan Gangguan Perkembangan Otakunclassified

Literatur Review: Hubungan Penggunaan Pestisida dengan Kejadian Gangguan Neurologis pada Petani

Ardiansyah,

Setiani,

Suhartono

2023

JSE

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Penggunaan pestisida pada daerah pertanian merupakan salah satu faktor yang menyebabkan terjadinya gejala gangguan neurologis pada petani. Penelitian ini bertujuan untuk menganalisis dampak dari penggunaan pestisida dengan kejadian gangguan neurologis pada para petani berdasarkan dari berbagai artikel terkait yang dikumpulkan. Jenis penelitian ini yaitu penelitian literature review, penelitian yang dilakukan dengan mengumpulkan artikel-artikel menggunakan mesin pencari seperti Scopus, Nature, dan Google Scholar. Kriteria artikel yang dijadikan acuan pada penelitian ini yaitu artikel terbitan tahun 2015-2023 serta artikel jenis open access dan full text. Dari hasil pencarian artikel serta skrining, didapatkan artikel final yang dipakai yaitu sebanyak 5 artikel, di mana dilakukan proses skrining sebanyak 2 kali dari yang awalnya 40 artikel menjadi hanya 5 saja yang dipakai. Hasil penelitian menunjukkan bahwa hampir semua petani selalu menggunakan pestisida saat bekerja. Paparan pestisida dapat menyebabkan gangguan neurologis pada petani, di mana gangguan neurologis tersebut antara lain Alzheimer, demensia, gangguan defisit perhatian, perubahan perilaku ke arah yang negatif, mengganggu tumbuh kembang sel otak. Insomnia juga dapat terjadi akibat dari paparan pestisida, di mana terganggunya fungsi enzim asetilkolinesterase dapat mengganggu kualitas tidur seseorang.

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“…The majority of studies in Thailand reported urinary dialkyl phosphate (DAP) metabolite levels which is a biomarker of organophosphate exposure. Recent studies in Thailand, farmers in all regions of Thailand had urine DAP levels that ranged from 87.32 to 122.2 microgram/gram creatinine ( 8–10 ). Additionally, the study by Suntudrob et al ( 11 ) monitored pesticide residues in vegetables from all provinces of Thailand, and reported that 22.3% of the samples had detectable pesticide residues with a range of <0.01–5.9 mg/kg.…”

Section: Introductionmentioning

confidence: 99%

Acute health symptoms related to perception and practice of pesticides use among farmers from all regions of Thailand

Sapbamrer,

Sittitoon,

Thongtip

et al. 2024

Front. Public Health

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IntroductionOccupational exposure to pesticides may cause acute health effects for farmers and agricultural workers. Therefore, this study aims to investigate the prevalence of poisoning symptoms related pesticide exposure among farmers from all regions of Thailand, as well as factors linked to poisoning symptoms of neurological and neuromuscular systems, the respiratory system, and eye and skin disorders.MethodsA cross sectional study was conducted in 4,035 farmers who lived in four regions of Thailand. The samples were chosen using stratified random sampling, with 746 for the Central region, 2,065 for the North-East, 586 for the North, and 638 for the South.ResultsThe results found that the highest prevalence of poisoning symptoms was found in association with neurological and neuromuscular systems (75%), followed by the respiratory system (60.4%), the eyes (41.2%), and skin (14.8%). The most prevalent symptoms were muscle pain (49%) for neurological and neuromuscular symptoms, burning nose (37.6%) for respiratory symptoms, itchy eyes (26.3%) for eye symptoms, and rashes (14.4%) for skin symptoms. The remarkable findings were that types of pesticide use, task on the farm, types of pesticide sprayers, and perception are the crucial factors affecting all poisoning symptoms.DiscussionThe findings are also beneficial to the Thai government and other relevant organizations for launching measures, campaigns, or interventions to lower modifiable risk factors, resulting in reducing health risks associated with pesticide exposure.

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Effects of urinary of organophosphate metabolites on nerve conduction and neurobehavioral performance among farmers in northern Thailand

Cited by 3 publications

References 49 publications

Brain-targeted nanoreactors prevent the development of organophosphate-induced delayed neurological damage

Brain-targeted nanoreactors prevent the development of organophosphate-induced delayed neurological damage

Literatur Review: Hubungan Penggunaan Pestisida dengan Kejadian Gangguan Neurologis pada Petani

Acute health symptoms related to perception and practice of pesticides use among farmers from all regions of Thailand

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