Effects of uridine administration on hippocampal matrix metalloproteinases and their endogenous inhibitors in REM sleep-deprived rats

Çakır, Ayşen; Öcalan, Büşra; Aydin, Birnur; Koçoğlu, Sema Serter; Cansev, Mehmet; Suyen, Guldal Gulec; Kahveci, Nevzat

doi:10.1016/j.brainres.2022.148039

Cited by 4 publications

(4 citation statements)

References 64 publications

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“…Galactose is converted to glucose and metabolized through the normal glucose metabolic pathway. The use of uridine has been shown to improve the composition of extracellular matrix (ECM) in rats with rapid eye movement SD (REMSD), [ 88 ] and may be helpful in the treatment of sleep disorders.…”

Section: Discussionmentioning

confidence: 99%

Systematic Metabolic Profiling of Mice with Sleep‐Deprivation

Si,

Sun,

Liang

et al. 2023

Advanced Biology

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Adequate sleep is essential for the biological maintenance of physical energy. Lack of sleep can affect thinking, lead to emotional anxiety, reduce immunity, and interfere with endocrine and metabolic processes, leading to disease. Previous studies have focused on long‐term sleep deprivation and the risk of cancer, heart disease, diabetes, and obesity. However, systematic metabolomics analyses of blood, heart, liver, spleen, kidney, brown adipose tissue, and fecal granules have not been performed. This study aims to systematically assess the metabolic changes in the target organs caused by sleep deprivation in vivo, to search for differential metabolites and the involved metabolic pathways, to further understand the impact of sleep deprivation on health, and to provide strong evidence for the need for early intervention.

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Section: Discussionmentioning

confidence: 99%

Systematic Metabolic Profiling of Mice with Sleep‐Deprivation

Si,

Sun,

Liang

et al. 2023

Advanced Biology

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show abstract

“…As a key part of ECM compositions, matrix metalloproteinases (MMPs) and their specific inhibitors are implicated in human pathogenesis [ 6 ]. Dysregulation of ECM composition occurs in the hippocampi after SD [ 9 , 10 ]. In agreement with previous findings [ 9 , 10 ], our data demonstrated the under-expression of ECM composition MMP9 and upregulation of MMP9 inhibitor TIMP-1 in mouse hippocampus after SD.…”

Section: Discussionmentioning

confidence: 99%

“…Dysregulation of ECM composition occurs in the hippocampi after SD [ 9 , 10 ]. In agreement with previous findings [ 9 , 10 ], our data demonstrated the under-expression of ECM composition MMP9 and upregulation of MMP9 inhibitor TIMP-1 in mouse hippocampus after SD.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between circadian rhythm-related genes and extracellular matrix: implications for sleep deprivation

Liu,

Sun,

Ling

et al. 2023

Sleep Breath

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Background Sleep deprivation (SD) can lead to the development of various pathological disorders. The extracellular matrix (ECM) compositions and circadian rhythm genes are two pivotal variables of SD. However, their relationships remain undefined during SD. Methods A mouse SD model was established using a modified multiplatform water environment method. The expression of nerve growth factor (NGF) in mouse hippocampus was detected by an immunofluorescence (IF) method. Protein expression was assessed by western blot, and mRNA analysis was performed by quantitative real-time PCR (qRT-PCR). The differentially expressed genes after SD, the genes associated with stromal score, and gene expression correlation were analyzed by bioinformatic analysis. Results The mouse model of SD was successfully established, as evidenced by the changed morphology, increased Bax and NGF levels, and downregulated Bcl-2 in mouse hippocampus after SD. The differentially expressed genes after SD were closely associated with the ECM compositions. The ECM composition metalloproteinase 9 (MMP9) was under-expressed in mouse hippocampus after SD. The hippocampal MMP9 expression was correlated with the expression levels of circadian genes PER2, PER3, TIMELESS, FBXL3, and NFIL3. PER2 and TIMELESS were upregulated in mouse hippocampus after SD. Conclusion The current findings suggest a correlation between ECM composition MMP9 and circadian rhythm-related genes PER2 and TIMELESS in mouse hippocampus after SD, providing a novel understanding of the disorders after SD.

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A novel process for developing a quantitative chromatographic fingerprint analysis method based on analytical quality by design: A case study of Xiaochaihu capsules

Ding,

Liu,

et al. 2023

Microchemical Journal

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Effects of uridine administration on hippocampal matrix metalloproteinases and their endogenous inhibitors in REM sleep-deprived rats

Cited by 4 publications

References 64 publications

Systematic Metabolic Profiling of Mice with Sleep‐Deprivation

Systematic Metabolic Profiling of Mice with Sleep‐Deprivation

Relationship between circadian rhythm-related genes and extracellular matrix: implications for sleep deprivation

A novel process for developing a quantitative chromatographic fingerprint analysis method based on analytical quality by design: A case study of Xiaochaihu capsules

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