Effects of Unilateral Entorhinal Cortex Lesion and Ganglioside GM1 Treatment on Performance in a Novel Water Maze Task

Glasier, Marylou M.; Sutton, Richard L.; Stein, Donald G.

doi:10.1006/nlme.1995.0003

Cited by 23 publications

(20 citation statements)

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“…Numerous reports show that lesions to hippocampal afferents, such as entorhinal cortex exert an effect not only on memory but also on other behavioral aspects (e.g. exploratory activity, locomotion) in rodents (Dasheiff and McNamara, 1982;Fass, 1983;Glasier et al, 1995;Scoville 1976, Steward, et al, 1977).…”

Section: Discussionmentioning

confidence: 96%

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Alterations of behavior and spatial learning after unilateral entorhinal ablation of rats

et al. 2006

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Section: Discussionmentioning

confidence: 96%

“…They used Hebb -Williams maze, 7 weeks after electrolytic cortex lesion of Sprague -Dawley rats. In other experiments performed with water maze, EC ablation effected deficits in working memory (Glasier et al, 1995). Also, studies on retention presented difference of spatial navigation_s strategy only in the first day.…”

Section: Discussionmentioning

confidence: 97%

Alterations of behavior and spatial learning after unilateral entorhinal ablation of rats

et al. 2006

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“…This raises the interesting possibility that damage to any of these retrohippocampal areas interrupted a "functional circuit" (Eichenbaum et al, 1994;Eichenbaum, 1997;Murray and Mishkin, 1998) through which information could be processed either in conjunction with (pretrained HCX-lesioned animals) or parallel to (naive HCX-lesioned animals) the hippocampus. Lesions of the entorhinal and perirhinal cortex that spare hippocampus in the rat also produce major deficits in delay-type tasks (Rothblat et al, 1993;Holscher and Schmidt, 1994;Glasier et al, 1995;Wiig and …”

Section: Discussionmentioning

confidence: 99%

Effects of Ibotenate Hippocampal and Extrahippocampal Destruction on Delayed-Match and -Nonmatch-to-Sample Behavior in Rats

1999

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The effects of ibotenate lesions of the hippocampus (HIPP) or hippocampus plus collateral damage to extrahippocampal structures (HCX) were investigated in rats trained to criterion on spatial versions of either a delayed-match (DMS) or delayednonmatch-to-sample (DNMS) task. After recovery from surgery, animals were retrained at "0" sec delays, then assessed at 0-30 sec delays for 15 d, retrained again at 0 sec delays, and retested for another 25 d on 0-30 sec delays. Pretrained HIPPlesioned animals showed marked delay-dependent deficits in both tasks that never recovered. Detailed examination of within-and between-trial performance factors, including changes in response preferences, length of previous trial delay, and sequential dependencies, revealed important factors operating in lesioned animals that were either absent or insignificant before the lesion. Pretrained HCX-lesioned animals showed deficits similar to those of HIPP animals, with the noticeable exception of a strong "recency" influence of the previous trial. Another group of HIPP-and HCX-lesioned animals trained on the tasks after the lesion showed reduced impairments of the type described above, suggesting that extrahippocampal structures trained after the lesion can assume the role of the hippocampus to some degree. The findings indicate that both the type of lesion and the previous history of the animal determine the postlesion DMS and DNMS performance of animals suffering damage to the hippocampus and/or related structures. Key words: ibotenate lesion; hippocampus; subiculum; entorhinal cortex; delay tasks; memory; trainingThe effects of hippocampal lesions on delayed-match (DMS) and delayed-nonmatch-to-sample (DNMS) performance have historically provided evidence of selective influences on short-versus long-term memory processes (Correll and Scoville, 1965;Olton and Feustle, 1981;Rawlins, 1985;Parkinson et al., 1988;Raffaele and Olton, 1988;Z ola-Morgan et al., 1993;Shaw and Aggleton, 1995). In recent years the validity of this assumption has been repeatedly tested with respect to the species of animal (Aggleton and Mishkin, 1985;Rothblat and Kromer, 1991;Gaffan and Murray, 1992;Rawlins et al., 1993), type of delay task used, (Parkinson et al., 1988;Dunnett, 1989;Rothblat and Kromer, 1991;Rawlins et al., 1993;Steele and Rawlins, 1993;Cassaday and Rawlins, 1995), number of choices available (Angeli et al., 1993;Gutnikov et al., 1994), type and extent of the lesion (Aggleton and Mishkin, 1985;Aggleton et al., 1989;Jarrard, 1989Jarrard, , 1993Coffey et al., 1990;Rawlins et al., 1993), nature of stimuli used (Angeli et al., 1993;Yee and Rawlins, 1994; C assaday and Rawlins, 1995), and methods of scoring the data (Ringo, 1991;Steele and Rawlins, 1993).Several of these issues can be reduced to four important aspects of DMS and DNMS behavior that have yet to be unequivocally determined in animals that have damage to the hippocampus and related structures. The first is whether the deficit in DMS and DNMS performance reported with lesions of the hippoca...

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“…Similarly, Van Cauter et al (2008) showed that single-unit activity in CA1 of rats with EC lesions represented space, but the spatial maps in CA1 of EC lesioned rats were less robust to cue rotation or removal, as compared to control rats. Other studies showed that EC lesions caused spatial learning and working memory deficits in Morris water maze (Glasier et al 1995(Glasier et al , 1999Good and Honey 1997;But see Bannerman et al 2001), although the rats with EC lesions clearly improved performance over the training period. Oswald et al (Oswald et al 2003) showed that rats with EC lesions learned to navigate using intramaze or extramaze cues, but failed to resolve conflicts between intramaze and extramaze cues.…”

Section: Lesion Studies Are Consistent With Partial Segregation Of "Wmentioning

confidence: 94%

Spatial and Nonspatial Representations in the Lateral Entorhinal Cortex

Deshmukh

2014

Space,Time and Memory in the Hippocampal Formation

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The hippocampus is thought to function as a "cognitive map," which stores nonspatial information such as items and events in a spatial framework. In order to understand the computations involved in creating such conjunctive nonspatial + spatial representations, it is essential to understand the function of hippocampal inputs. Medial entorhinal cortex (MEC) is known to convey spatial information to the hippocampus. In this chapter, we discuss recent evidence showing that lateral entorhinal cortex (LEC) conveys both spatial and nonspatial information to the hippocampus, in the presence of objects. Perirhinal cortex (PRC), a major cortical input to LEC, encodes nonspatial, object-related information, but does not encode spatial information in the presence of objects. Thus, the landmark-derived spatial information arises de novo in LEC. The classical dual-pathway model, in which LEC encodes nonspatial information while MEC encodes spatial information, cannot account for LEC spatial representation in the presence of objects. We propose that the functional difference between LEC and MEC is better understood in terms of the different inputs they use to create their representations: LEC generates spatial as well as nonspatial representations by processing external sensory inputs in contrast to MEC, which generates spatial representations by processing internally based path integration information.

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Effects of Unilateral Entorhinal Cortex Lesion and Ganglioside GM1 Treatment on Performance in a Novel Water Maze Task

Cited by 23 publications

References 0 publications

Alterations of behavior and spatial learning after unilateral entorhinal ablation of rats

Alterations of behavior and spatial learning after unilateral entorhinal ablation of rats

Effects of Ibotenate Hippocampal and Extrahippocampal Destruction on Delayed-Match and -Nonmatch-to-Sample Behavior in Rats

Spatial and Nonspatial Representations in the Lateral Entorhinal Cortex

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