Effects of Unilateral and Bilateral Carotid Baroreflex Stimulation on Cardiac and Neural Sympathetic Discharge Oscillatory Patterns

Furlan, Raffaello; Diedrich, André; Rimoldi, Alexandra; Palazzolo, Laura; Porta, Cesare; Diedrich, Laura; Harris, Paul A.; Sleight, Peter; Biagioni, Italo; Robertson, David; Bernardi, Luciano

doi:10.1161/01.cir.0000084540.91605.0c

Cited by 31 publications

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“…Unilateral carotid baroreceptor afferent stimulation resulted in a similar increase in the 0.1-Hz component of MSNA variability (11).…”

Section: Discussionmentioning

confidence: 71%

“…The modulatory activity on MSNA played by the carotid component of arterial baroreceptors was recently assessed in a study based on right-and left-unilateral sinusoidal 0.1-Hz neck suctions and single MSNA recordings (11). Unilateral carotid baroreceptor afferent stimulation resulted in a similar increase in the 0.1-Hz component of MSNA variability (11).…”

Section: Discussionmentioning

confidence: 99%

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Lateralization of expression of neural sympathetic activity to the vessels and effects of carotid baroreceptor stimulation

Diedrich¹,

Porta²,

Barbic³

et al. 2009

American Journal of Physiology-Heart and Circulatory Physiology

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Furlan R. Lateralization of expression of neural sympathetic activity to the vessels and effects of carotid baroreceptor stimulation. Am J Physiol Heart Circ Physiol 296: H1758 -H1765, 2009. First published April 10, 2009 doi:10.1152/ajpheart.01045.2008.-Human studies suggest that cardiovascular neural sympathetic control is predominantly modulated by the right cerebral hemisphere. It is unknown whether post-ganglionic sympathetic activity [muscle sympathetic nerve activity (MSNA)] shows any functional asymmetry. Eight right-handed volunteers (3 women and 5 men, 32 Ϯ 2 yr of age) underwent ECG, beat-by-beat blood pressure, respiratory activity, and simultaneous right and left MSNA recordings during spontaneous and controlled breathing (CB, 15 breaths/min, 0.25 Hz). Dynamic carotid baroreceptor stimulation was obtained by 0.1-Hz sinusoidal suction, from 0 to Ϫ50 mmHg, randomly applied to the right, left, and combined right and left sides of the neck during CB. Laterality was assessed by changes in the MSNA burst rate (in bursts/min, and bursts/100 beats), strength [amplitude (A) and area (AA)], and the oscillatory component at 0.1 Hz during baroreceptor stimulation. Amplitude parameters were normalized by CB burst mean amplitude and area of the same side. At rest, the right and left MSNA burst rate and total MSNA activity were similar. Conversely, the right MSNA normalized burst AN (1.36 Ϯ 0.18) and AAN (1.31 Ϯ 0.16) were larger than the left MSNA AN (1.04 Ϯ 0.09) and AAN (1.02 Ϯ 0.08). Unilateral and bilateral carotid baroreflex stimulation abolished the right prevalence of AN and AAN. In conclusion, the right lateralization of sympathetic activity to the vessels is indicated by normalized burst strength parameters of bilateral MSNA recordings at rest during spontaneous breathing. Carotid baroreceptor stimulation disrupted such expression of MSNA lateralization possibly by disturbing the synchronizing action of right cerebral hemisphere. sympathetic control of circulation; muscle sympathetic nerve activity recording; burst amplitude; area; laterality SEVERAL HUMAN STUDIES support the concept that the neural sympathetic activity regulating the cardiovascular system undergoes a predominant modulation exerted by the right cerebral hemisphere (2, 4, 10, 17-19, 33, 34). The right side of the medulla was also found to be involved in cardioacceleration in vagotomized animals (16). However, it has to be pointed out that the large majority of these investigations focused on functional modifications of the sympathetic target organs, i.e., on changes of heart rate and blood pressure and their variability, and did not focus on a direct measure of right and left efferent sympathetic activity.Two studies (27, 28) addressed the problem of the potential dissimilarity between the right and left neural efferent sympathetic activity by recording simultaneously muscle sympathetic nerve activity (MSNA) in both peroneal nerves in humans. Sundlof and Wallin (27) focused on burst rate, which was found to be similar in the right and le...

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“…Unilateral carotid baroreceptor afferent stimulation resulted in a similar increase in the 0.1-Hz component of MSNA variability (11).…”

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Lateralization of expression of neural sympathetic activity to the vessels and effects of carotid baroreceptor stimulation

Diedrich¹,

Porta²,

Barbic³

et al. 2009

American Journal of Physiology-Heart and Circulatory Physiology

Self Cite

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“…Baroreceptor stimulation NS was applied to a flexible, moulded lead neck collar placed on the anterior neck region, connected to a vacuum pump [3,4,10]. A computer-controlled rotary valve, Fig.…”

Section: Protocolmentioning

confidence: 99%

“…Baroreceptor stimulation was obtained by a flexible, moulded lead neck collar connected to a vacuum pump. During each recording electrocardiogram (lead II), respiration (by inductive plethysmographic band), postural sway (platform pressure sensors), blood pressure (Portapres Ó , FMS, Amsterdam, The Netherlands) and pressure within the neck collar during baroreceptor stimulation (by Statham P23d pressure transducer) were monitored previously designed and built in our laboratory [10], provided a sinusoidal suction profile for pressure ranging from 0 to -30 mmHg. The sinusoidal change in (negative) pressure imposed at the neck activates and deactivates the carotid baroreceptors.…”

Section: Protocolmentioning

confidence: 99%

“…Activation of carotid sinus baroreceptors can be achieved by applying an external suction to the neck [2][3][4]10]. Sinusoidal stimulation, rather than single pulses or transitions, offers several advantages: it does not produce startle reactions or movement artefacts, can be administered through a wide frequency range (0.05-0.30 Hz) and can be easily separated from the influence of respiration (because suction of the neck and respiration can be set at separate frequencies).…”

Section: Introductionmentioning

confidence: 99%

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