Effects of undernutrition on diaphragm fiber size, SDH activity, and fatigue resistance

Sieck, Gary C.; Lewis, Michael I.; Blanco, Cesar E.

doi:10.1152/jappl.1989.66.5.2196

Cited by 105 publications

(114 citation statements)

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“…COPD patients use accessory breathing muscles almost constantly to breathe, and this may cause such a training effect. In animal studies, malnutrition has shown a relative increase of type I fibres [27,28]. Since, in this study, the COPD patients suffered from tissue depletion compared to the healthy subjects, differences in fibre composition may have been a contributing factor to an earlier metabolic adaptation in the patients.…”

Section: Discussionmentioning

confidence: 67%

Metabolic and ventilatory response pattern to arm elevation in patients with COPD and healthy age-matched subjects

Baarends¹,

Schols²,

Slebos³

et al. 1995

Eur Respir J

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M Me et ta ab bo ol li ic c a an nd d v ve en nt ti il la at to or ry y r re es sp po on ns se e p pa at tt te er rn n t to o a ar rm m e el le ev va at ti io on n i in n p pa at ti ie en nt ts s w wi it th h C CO OP PD D a an nd d h he ea al lt th hy y a ag ge e--m ma at tc ch he ed d s su ub bj je ec ct ts s Each subject consecutively performed three types of arm elevation for 2 min, with 3 min rest periods in between. Breath-by-breath metabolic and ventilatory parameters and heart rate (HR) were registered during a 3 min baseline period and throughout the measurement period.Adjusted for significantly greater baseline test results in COPD patients, it was found that AE (arm elevation including recovery) tended to be more demanding with respect to metabolic and ventilatory response for patients with COPD than for the age-matched healthy subjects. Arm elevation resulted in an increase in oxygen consumption (V ' 'O 2 ) (COPD 12%; healthy 6%), carbon dioxide elimination V ' 'CO 2 (COPD 15%; healthy 10%), minute ventilation V ' 'E (COPD 13%; healthy 7%) and heart rate (COPD 2%; healthy 5%). A pronounced difference was found in the pattern of metabolic and ventilatory response to arm elevation, i.e. there was an earlier but sluggish V ' 'O 2 onset in COPD patients, whereas the healthy subjects demonstrated a sudden peak approximately 30 s after arm elevations. Mutual comparison of the three different types of arm elevation demonstrated a comparable response pattern.Knowledge of the specific response to arm elevations in COPD patients seems essential for interpretation of arm elevation tests in upper extremity rehabilitation programmes. Eur Respir J., 1995Respir J., , 8, 1345Respir J., -1351 Patients with severe chronic obstructive pulmonary disease (COPD) often complain of dyspnoea during activities of daily living, such as combing their hair, brushing their teeth or shaving [1][2][3]. These activities mainly involve (unsupported) movements of arm and shoulder muscles.Several factors may contribute to impairment of unsupported arm activities in COPD patients, such as a dual activity of shoulder muscles in breathing as well as movement [4,5], and peripheral [6] and respiratory [7] skeletal muscle weakness.In order to examine the possible limitations of (unsupported) arm activities in patients with COPD, other investigators have studied the metabolic and ventilatory requirements of simple arm elevation. In all studies, arm elevation resulted in a significant increase in metabolic and ventilatory requirements [3,4,5,8]. Possible differences in metabolic and ventilatory response pattern following arm elevation between COPD patients and healthy persons, however, have not yet been specified. Furthermore, it may be hypothesized that the response pattern depends on the type of arm elevation due to different muscle recruitment.In this study, the metabolic and ventilatory requirements of three basic arm elevations were compared between COPD patients and healthy age-matched control subjects. Material and methods Study popula...

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Section: Discussionmentioning

confidence: 67%

Metabolic and ventilatory response pattern to arm elevation in patients with COPD and healthy age-matched subjects

Baarends¹,

Schols²,

Slebos³

et al. 1995

Eur Respir J

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“…Muscle fibers with a mainly oxidative met abolic pathway are relatively resistant to ND-induced catabolism (28,30). This may explain why, in the pres ent study, ND affected type I and Ha fibers less than type lib fibers.…”

Section: Discussionmentioning

confidence: 82%

“…This degree of wasting on it s e lf , e.g., induced by nutritional depletion (ND), may c a u s e structural changes in the DIA, accompanied by abnorm alities in contractile properties (14,15,18,30). T h e s e studies, however, were discrepant with regard to t h e fiber types affected.…”

mentioning

confidence: 99%

Corticosteroid treatment and nutritional deprivation cause a different pattern of atrophy in rat diaphragm

Dekhuijzen

Gayan‐Ramirez

Bisschop

et al. 1995

Journal of Applied Physiology

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Triamcinolone (TR) causes type IIb fiber atrophy in the rat diaphragm, which is associated with changes in contractile properties. We investigated whether this is a direct effect of TR or the result of an accompanying loss of body and diaphragm weights. For 6 wk, adult rats received saline intramuscularly, TR (0.5 mg/kg im), or nutritional depletion (ND) that resulted in a similar (approximately 40%) reduction in body weight as TR. In these animals, the half-relaxation time of the diaphragm bundles increased, the force-frequency relationship shifted leftward, and the resistance to fatigue was increased. No histological changes were found in the ND diaphragm, in contrast to severe myogenic alterations in the TR diaphragm. Type IIb fiber cross-sectional area (CSA) in the TR diaphragm was reduced by 51%, whereas type I and IIa CSAs were unaffected. In the ND animals, the CSAs of type I, IIa, and IIb fibers were reduced by 31, 33, and 52%, respectively. Similar changes occurred in the deep part of the m. gastrocnemius. In conclusion, myogenic changes and selective type IIb fiber atrophy were caused by TR, whereas ND induced generalized fiber type atrophy without histological changes.

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“…The possible role of malnutrition is demonstrated by animal studies in which nutritional deprivation caused depressed muscular mitochondrial capacity [33][34][35]. Physical inactivity or disuse of limb muscles are potential contributors to the observed fibre-type shift [36].…”

Section: Discussionmentioning

confidence: 99%

Skeletal muscle fibre-type shifting and metabolic profile in patients with chronic obstructive pulmonary disease

Gosker¹,

Mameren²,

Dijk³

et al. 2002

Eur Respir J

248

207

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The aim of this study was to examine the nature of fibre-type redistribution in relation to fibre metabolic profile in the vastus lateralis in chronic obstructive pulmonary disease (COPD) and COPD subtypes.Fifteen COPD patients (eight with emphysema stratified by high-resolution computed tomography) and 15 healthy control subjects were studied. A combination of myofibrillar adenosine triphosphatase staining and immunohistochemistry was used to identify pure, as well as hybrid fibre types. For oxidative capacity, fibres were stained for cytochrome c oxidase and succinate dehydrogenase activities, and glycogen phosphorylase for glycolytic capacity.The proportion of type-I fibres in COPD patients was markedly lower (16% versus 42%), especially in emphysema, and the proportion of hybrid fibres was higher (29% versus 16%) compared to controls. The proportion of fibres staining positive for oxidative enzymes was lower in COPD patients, which correlated with the proportion of type-I fibres. In COPD oxidative capacity was lower within IIA fibres.The authors conclude that fibre-type transitions are involved in the fibre-type redistribution in chronic obstructive pulmonary disease. Low oxidative capacity is closely related to the proportion of type-I fibres, but an additional reduction of oxidative enzyme activity is present within IIA fibres. Fibre-type abnormalities may be aggravated in emphysema.

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Effects of undernutrition on diaphragm fiber size, SDH activity, and fatigue resistance

Cited by 105 publications

References 0 publications

Metabolic and ventilatory response pattern to arm elevation in patients with COPD and healthy age-matched subjects

Metabolic and ventilatory response pattern to arm elevation in patients with COPD and healthy age-matched subjects

Corticosteroid treatment and nutritional deprivation cause a different pattern of atrophy in rat diaphragm

Skeletal muscle fibre-type shifting and metabolic profile in patients with chronic obstructive pulmonary disease

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