Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function

Milliken, Sarah V.I.; Wassall, Heather; Lewis, B. J.; Logie, John; Barker, Robert N.; Macdonald, Helen; Vickers, Mark A.; Ormerod, Anthony

doi:10.1016/j.jaci.2012.03.001

Cited by 61 publications

(61 citation statements)

References 51 publications

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“…The modification included the addition of rice as the major cereal of diet in people from sunnier climate countries and excluded pancakes/crumpets. For dietary vitamin D intake, a short questionnaire which included the few foods containing vitamin D in the UK was used [20]. To consolidate the dietary assessment, foods from the calcium and vitamin D questionnaires were combined into a single questionnaire.…”

Section: Dietary Calcium and Vitamin D Intakementioning

confidence: 99%

The relationship between vitamin D status and muscle strength in young healthy adults from sunny climate countries currently living in the northeast of Scotland

et al. 2017

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The relationship between vitamin D status and muscle strength in young healthy adults from sunny climate countries currently living in the northeast of Scotland. Osteoporosis International, 28(4), pp. 1433-1443. (doi:10.1007 This is the author's final accepted version.There may be differences between this version and the published version. 1 Abstract SummaryThe current study examined the relationship between vitamin D status and muscle strength in young healthy adults: residents (> 6 months) and newcomers (0-3 months), originally from sunny climate countries but currently living in the northeast of Scotland. Our longitudinal data found a positive, albeit small, relationship between vitamin D status and knee extensor isometric strength. IntroductionVitamin D has been suggested to play a role in muscle health and function, but studies so far have been primarily in older populations for falls prevention and subsequent risk of fractures.

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Section: Dietary Calcium and Vitamin D Intakementioning

confidence: 99%

The relationship between vitamin D status and muscle strength in young healthy adults from sunny climate countries currently living in the northeast of Scotland

et al. 2017

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“…However, as reported in other autoimmune diseases [2,7,9,29,31], there is emerging evidence in favor of the importance of nondietary environmental factors in the later CD and especially the role of environmental factors related to the season of birth. In particular, the infectious diseases caused by rotavirus and astrovirus [30,32,37] as well as the fluctuating vitamin D level might be reflected in a seasonal variation in CD risk related to month of birth [19,28,34].…”

Section: Introductionmentioning

confidence: 99%

Impact of the birth’s season on the development of celiac disease in Italy

et al. 2015

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“…Delineating the Vitamin D-mediated effects from the many other factors that are produced following UVB exposure is difficult. However, recent studies have shown that UVB does modulate the immune response independently of Vitamin D in both mice (Schwarz et al 2012;Gorman et al 2012) and humans (Milliken et al 2012). Indeed, UVB-protection of mice from EAE is not due to UVB-induced Vitamin D (Becklund et al 2010;Wang et al 2013).…”

Section: Increased Exposure To Uv Correlates With Lower Ms Incidencementioning

confidence: 99%

Photoimmunology and Multiple Sclerosis

Marsh‐Wakefield

Byrne

2015

Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments

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The ultraviolet (UV) radiation contained in sunlight is a powerful immune suppressant. While exposure to UV is best known for its ability to cause skin cancer, it is also associated with protection against a range of autoimmune diseases, particularly multiple sclerosis (MS). Although the precise mechanism by which sunlight affords protection from MS remains to be determined, some have hypothesised that UV immunosuppression explains the "latitude-gradient effect" associated with MS. By stimulating the release of soluble factors in exposed skin, UV activates immune suppressive pathways that culminate in the induction of regulatory cells in distant tissues. Each and every one of the immune suppressive cells and molecules activated by UV exposure are potential targets for treating and preventing MS. A thorough understanding of the mechanisms involved is therefore required if we are to realise the therapeutic potential of photoimmunology.

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Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function

Cited by 61 publications

References 51 publications

The relationship between vitamin D status and muscle strength in young healthy adults from sunny climate countries currently living in the northeast of Scotland

The relationship between vitamin D status and muscle strength in young healthy adults from sunny climate countries currently living in the northeast of Scotland

Impact of the birth’s season on the development of celiac disease in Italy

Photoimmunology and Multiple Sclerosis

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