Effects of Ultrafine Particles in Ambient Air on Primary Health Care Consultations for Diabetes in Children and Elderly Population in Ljubljana, Slovenia: A 5-Year Time-Trend Study

Hrženjak, Vesna; Kukec, Andreja; Eržen, Ivan; Stanimirović, Dalibor

doi:10.3390/ijerph17144970

Cited by 5 publications

(6 citation statements)

References 77 publications

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“…It is also important to note that residual surface‐bound implant particulate is not continually released in vivo but, as a worst case, can be assumed to be a one‐time bolus dose. Further comparison of exposure level of residual implant particle criteria to everyday exposure (i.e., <1 × 10 7 particles for <1 μm sized residual particles) indicates that it is approximately equivalent to the amount of 0.1 μm sized particles inhaled in 10 average breaths of good quality outdoor air in rural conditions (i.e., 1.3 × 10 6 particles per breath: 0.1 μm particles: 2610 × 10 6 particles/m 3 in good quality rural air, at 500 mL per average breath) 36–38 …”

Section: Discussionmentioning

confidence: 99%

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Characterization of residual debris on packaged hip arthroplasty stems demonstrates the dominance of less than 10 μm sized particulate: Updated USP788 guidelines for orthopedic implants

Hallab,

Alexander

et al. 2024

J Biomed Mater Res

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Past evaluation of particle contamination on packaged implants has typically been conducted using US Pharmacopeia (USP) 788, a 1970s pharmaceutical guideline created to evaluate contaminant particles in injectable fluids and syringes. Our objective was to reestablish relevant acceptance criteria for residual orthopedic and other implant debris, including smaller particles (i.e., <10 μm in diameter). Packaged total hip arthroplasty (THA) titanium (Ti6Al4V)‐alloy femoral stems were used (hydroxyapatite [HA]‐coated and non‐coated stems). Short‐term ultrasonication and longer‐term 24‐hour soak/agitation methods were used to elute surface‐bound contaminant particles, and released particles were analyzed via scanning electron microscopy, energy‐dispersive x‐ray analysis, image analysis, and particle characterization. For HA‐coated THA‐stems, >99% of eluted particles were calcium phosphate. For plain non‐coated THA‐stems, >99% of eluted particles were titanium‐alloy‐based. The number‐based median size of particles in both groups was approximately 1.5 μm in diameter despite being composed of different materials. The total volume of particulate removed from HA‐coated stems was 0.037 mm3 (671 × 103 particles total), which was approximately >50‐fold more volume than that on plain non‐coated stems at 0.0006 mm3 (89 × 103 particles total). Only non‐coated THA stems passed reestablished USP788 acceptance criteria, compared by using equivalent total volumes of contaminant particulate within new and legacy guideline ranges of >10 and >25 μm ECD, that is, <1.0 × 107 particles for <1 μm diameter in size, <600,000 for <1–10 μm, <6000 for 10–25 μm and <600 for >25 μm. These results fill a knowledge gap on how much residual debris can be expected to exist on packaged implants and can be used as a basis for updating acceptance criteria (i.e., termed USP788‐Implant [USP788‐I]). Residual implant particulate assessment is critical given the increasing implant complexity and new manufacturing techniques (e.g., additive manufacturing).

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Section: Discussionmentioning

confidence: 99%

“…that it is approximately equivalent to the amount of 0.1 μm sized particles inhaled in 10 average breaths of good quality outdoor air in rural conditions (i.e., 1.3 Â 10 6 particles per breath: 0.1 μm particles: 2610 Â 10 6 particles/m 3 in good quality rural air, at 500 mL per average breath) [36][37][38]. …”

mentioning

confidence: 99%

Characterization of residual debris on packaged hip arthroplasty stems demonstrates the dominance of less than 10 μm sized particulate: Updated USP788 guidelines for orthopedic implants

Hallab,

Alexander

et al. 2024

J Biomed Mater Res

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“…9 UFPs can even enter the brain through the olfactory nerves 10,11 and cause brain damage, which is associated with Alzheimer's and Parkinson's diseases. 12,13 Exposure to UFPs might cause more severe health risks to the sensitive groups including older adults 14 and children. 15,16 Particle number concentration (PNC) is the most commonly used measure to characterize UFPs and to evaluate their exposure risks.…”

Section: Introductionmentioning

confidence: 99%

Traffic, marine ships and nucleation as the main sources of ultrafine particles in suburban Shanghai, China

Wang,

Huo,

Chen

et al. 2023

Environ. Sci.: Atmos.

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“…The introduction of new technologies requires additional health care workers and proper training. On the other hand, new health risks are emerging due to lifestyle changes, pollution, and epidemiological threats [8]. All of this is leading to continually increasing the number of health care workers and spending on health care, and poses serious concerns for the sustainability of health care systems in many countries.…”

Section: Introductionmentioning

confidence: 99%

Human Resource Planning in Health Care: Outlining a Basic Model and Related Complexities

Stanimirović

Brinovec

2022

Studies in Health Technology and Informatics

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The effectiveness of the health care system is largely dependent on the knowledge, skills, and motivation of health care workers, which was particularly evident during the COVID-19 pandemic. The systemic planning of human resources is therefore an important condition for ensuring the sustainability and efficiency of the health care system. This article focuses on outlining a basic model of human resource planning in health care and the investigation of related complexities. An in-depth analysis framework based on various materials and evidence is proposed in order to outline the factors that influence human resource planning in health care. In order to achieve greater credibility of the research results, the in-depth analytical process employs an extensive review of the literature and carries out an investigation of numerous sources and materials, in both the national and international contexts. The purpose of the human resource planning initiatives in health care is to calculate the needed number of health care workers in the future, on the basis of past and current data, and based on assumptions about future trends in supply and demand. The research findings reveal that this is a very challenging task, as there are typically many unknowns in future planning, and, in addition, planners often face a lack of reliable data and systemic deficiencies. Moreover, the study indicates that unplanned and delayed solutions concerning the human resource needs in health care can only alleviate problems, but in no way can they replace effective strategic measures and timely structural changes within the health care ecosystem.

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Effects of Ultrafine Particles in Ambient Air on Primary Health Care Consultations for Diabetes in Children and Elderly Population in Ljubljana, Slovenia: A 5-Year Time-Trend Study

Cited by 5 publications

References 77 publications

Characterization of residual debris on packaged hip arthroplasty stems demonstrates the dominance of less than 10 μm sized particulate: Updated USP788 guidelines for orthopedic implants

Characterization of residual debris on packaged hip arthroplasty stems demonstrates the dominance of less than 10 μm sized particulate: Updated USP788 guidelines for orthopedic implants

Traffic, marine ships and nucleation as the main sources of ultrafine particles in suburban Shanghai, China

Human Resource Planning in Health Care: Outlining a Basic Model and Related Complexities

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