Effects of ulipristal acetate on human embryo attachment and endometrial cell gene expression in an in vitro co-culture system

Berger, Cecilia; Boggavarapu, Nageswara Rao; Menezes, Judith; Lalitkumar, P. G. L.; Gemzell‐Danielsson, Kristina

doi:10.1093/humrep/dev030

Cited by 64 publications

(31 citation statements)

References 80 publications

(95 reference statements)

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“…It does not appear to impair sperm function [47]. Some studies have shown that UPA may alter certain endometrial parameters, although in-vitro studies show no difference in the ability of embryos to implant when exposed or not exposed to UPA [48]. The best available evidence suggests that the primary mechanism of UPA in doses used for EC is interference with ovulation [16, 49].…”

Section: Ulipristal Acetatementioning

confidence: 99%

State of emergency contraception in the U.S., 2018

Haeger¹,

Lamme²,

Cleland³

2018

Contracept Reprod Med

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Emergency contraception is indicated in instances of unprotected sexual intercourse, including reproductive coercion, sexual assault, and contraceptive failure. It plays a role in averting unintended pregnancies due to inconsistent use or non-use of contraception. Options for emergency contraception vary by efficacy as well as accessibility within the U.S. This paper provides an overview of levonorgestrel (Plan B One-Step and generic counterparts), ulipristal acetate (sold as ella), and the copper intrauterine device (IUD, sold as ParaGard), including the mechanisms of action, administration, efficacy, drug interactions, safety, side effects, advantages, and drawbacks. It will also review current misconceptions about emergency contraception and access for subpopulations, including adolescents, immigrants, survivors of sexual assault, rural populations, and military/veteran women. This paper will address barriers such as gaps in knowledge, and financial, health systems, and practice barriers. Continuing areas of research, including the impact of body weight on the efficacy of emergency contraceptive pills and potential interactions between ulipristal acetate and ongoing hormonal contraceptives, are also addressed.

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Section: Ulipristal Acetatementioning

confidence: 99%

State of emergency contraception in the U.S., 2018

Haeger¹,

Lamme²,

Cleland³

2018

Contracept Reprod Med

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“…This means that UPA has a wider window of action than LNG and remains effective in the immediate preovulatory phase when the risk of conception is greatest, hence explaining its higher efficacy compared with LNG in clinical trials . Postovulatory administration of UPA at the EC dose may induce some immunohistochemical and molecular changes in the endometrium, but other in vitro studies have shown that UPA at concentrations relevant for EC do not interfere with embryo attachment to the endometrium . UPA at pharmacological concentrations can suppress ciliary beating and muscular contractility in fallopian tube, as well as modulate sperm function by inhibiting sperm hyperactivation, progesterone‐induced acrosome reaction and calcium influx .…”

Section: Mechanisms Of Action Of Ecmentioning

confidence: 99%

“…Indirect evidence from in vitro studies also showed that LNG or UPA at EC doses had no effect on human blastocyst viability in spite of sufficient time being allowed for the embryo to undergo any degenerative changes that LNG or UPA could possibly cause within the culture system.…”

Section: Safety Of Ecmentioning

confidence: 99%

“…42 Regarding the Yuzpe regimen, there is some reassurance extrapolating from a meta-analysis of 12 available prospective studies on around 6000 exposed women that did not find any statistically significant association between oral contraceptive use in early pregnancy and fetal malformation. 62 Indirect evidence from in vitro studies also showed that LNG or UPA at EC doses had no effect on human blastocyst viability 28,29,41 in spite of sufficient time being allowed for the embryo to undergo any degenerative changes that LNG or UPA could possibly cause within the culture system.…”

Section: Does Ec Exposure Have a Harmful Effect On A Pregnancy?mentioning

confidence: 99%

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Current controversies with oral emergency contraception

Cameron

Gemzell‐Danielsson

2017

BJOG

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“…Nonetheless, in vitro models using epithelial cells provide a useful means with which to investigate potential interactions that might occur in vivo, and allow workers to systematically evaluate the complex network of biological pathways involved in implantation (Teklenburg and Macklon, 2009;Weimar et al, 2013;Berger et al, 2015).…”

Section: In Vitro Modelsmentioning

confidence: 99%

Molecular mechanisms of membrane interaction at implantation

Davidson

Coward

2016

Birth Defects Research Pt C

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Successful pregnancy is dependent upon the implantation of a competent embryo into a receptive endometrium. Despite major advancement in our understanding of reproductive medicine over the last few decades, implantation failure still occurs in both normal pregnancies and those created artificially by assisted reproductive technology (ART). Consequently, there is significant interest in elucidating the etiology of implantation failure. The complex multistep process of implantation begins when the developing embryo first makes contact with the plasma membrane of epithelial cells within the uterine environment. However, although this biological interaction marks the beginning of a fundamental developmental process, our knowledge of the intricate physiological and molecular processes involved remains sparse. In this synopsis, we aim to provide an overview of our current understanding of the morphological changes which occur to the plasma membrane of the uterine endothelium, and the molecular mechanisms that control communication between the early embryo and the endometrium during implantation. A multitude of molecular factors have been implicated in this complex process, including endometrial integrins, extracellular matrix molecules, adhesion molecules, growth factors, and ion channels. We also explore the development of in vitro models for embryo implantation to help researchers investigate mechanisms which may underlie implantation failure. Understanding the precise molecular pathways associated with implantation failure could help us to generate new prognostic/diagnostic biomarkers, and may identify novel therapeutic targets.

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Effects of ulipristal acetate on human embryo attachment and endometrial cell gene expression in an in vitro co-culture system

Abstract: Swedish Research Council (K2010-54X-14212-09-3) and support provided through the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska University Hospital.

Cited by 64 publications

References 80 publications

State of emergency contraception in the U.S., 2018

State of emergency contraception in the U.S., 2018

Current controversies with oral emergency contraception

Molecular mechanisms of membrane interaction at implantation

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