Effects of two-month treatment with a mixture of natural activators of autophagy on oxidative stress and arterial stiffness in patients with essential hypertension: A pilot study

Biondi‐Zoccai, Giuseppe; Forte, Maurizio; Gallo, Giovanna; Nardoianni, Giulia; Fiori, E.; D’Ambrosio, Luca; Pietro, Riccardo Di; Cannata, F.; Rocco, Erica; Simeone, Bruno; Sarto, Gianmarco; Schirone, Leonardo; D’Amico, Alessandra; Peruzzi, Mariangela; Nocella, Cristina; Volpe, Massimo; Rubattu, Speranza

doi:10.1016/j.numecd.2023.07.026

Nutrition, Metabolism and Cardiovascular Diseases

2023

DOI: 10.1016/j.numecd.2023.07.026

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Effects of two-month treatment with a mixture of natural activators of autophagy on oxidative stress and arterial stiffness in patients with essential hypertension: A pilot study

Giuseppe Biondi‐Zoccai

Maurizio Forte

Giovanna Gallo

et al.

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2024

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Mitophagy modulation for the treatment of cardiovascular diseases

Forte,

D'Ambrosio,

Schiattarella

et al. 2024

Eur J Clin Investigation

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BackgroundDefects of mitophagy, the selective form of autophagy for mitochondria, are commonly observed in several cardiovascular diseases and represent the main cause of mitochondrial dysfunction. For this reason, mitophagy has emerged as a novel and potential therapeutic target.MethodsIn this review, we discuss current evidence about the biological significance of mitophagy in relevant preclinical models of cardiac and vascular diseases, such as heart failure, ischemia/reperfusion injury, metabolic cardiomyopathy and atherosclerosis.ResultsMultiple studies have shown that cardiac and vascular mitophagy is an adaptive mechanism in response to stress, contributing to cardiovascular homeostasis. Mitophagy defects lead to cell death, ultimately impairing cardiac and vascular function, whereas restoration of mitophagy by specific compounds delays disease progression.ConclusionsDespite previous efforts, the molecular mechanisms underlying mitophagy activation in response to stress are not fully characterized. A comprehensive understanding of different forms of mitophagy active in the cardiovascular system is extremely important for the development of new drugs targeting this process. Human studies evaluating mitophagy abnormalities in patients at high cardiovascular risk also represent a future challenge.

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Mitophagy modulation for the treatment of cardiovascular diseases

Forte,

D'Ambrosio,

Schiattarella

et al. 2024

Eur J Clin Investigation

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Effects of two-month treatment with a mixture of natural activators of autophagy on oxidative stress and arterial stiffness in patients with essential hypertension: A pilot study

Cited by 1 publication

References 32 publications

Mitophagy modulation for the treatment of cardiovascular diseases

Mitophagy modulation for the treatment of cardiovascular diseases

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