Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility

Ni, Qing; Ji, Anlai; Yin, Jun-Feng; Wang, Xiangjun; Liu, Xinnong

doi:10.1155/2015/764163

Cited by 16 publications

(8 citation statements)

References 69 publications

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“…Our results indicate that both polymorphisms are significantly associated with increased HCC risk. In line with other studies, the miR-146a rs2910164 and miR-196a-2 rs11614913 polymorphisms are associated with increased risk for other cancers like colorectal cancer ( Xu & Tang, 2015 ) and gastric cancer ( Ni et al, 2015 ) in the Asian population. The increased risk estimates found in our analysis are somewhat modest (OR < 1.6).…”

Section: Discussionsupporting

confidence: 88%

Common functional polymorphism within miR-146a and miR-196a-2 as susceptibility loci for hepatocellular carcinoma: An updated meta-analysis

Luo

Xiang

et al. 2016

Meta Gene

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BackgroundMutations or single nucleotide polymorphisms (SNPs) within the gene region of microRNAs play an important role for the development of hepatocellular carcinoma (HCC). Extensive studies have tried to investigate the susceptibility role of miR-146a rs2819164 and miR-196a-2 rs11614913. However, these results are still inconsistent and inconclusive. We undertook a meta-analysis containing primarily Asian studies to assess the associations of the two SNPs with HCC risk.Methods19 studies including miR-146a (7170 cases and 9443 controls) and 15 studies including miR-196a-2 (6417 cases and 7627 controls) were used for meta-analysis. Odds ratios and 95% CI were calculated to assess the association in five different genetic models.ResultsFor the rs2910164 polymorphism of miR-146a, significantly increased risks for HCC were observed when all studies were pooled under two models (CG vs CC: OR = 1.11, 95% CI = 1.02–1.21, P = 0.021; GG + CG vs CC: OR = 1.11, 95% CI = 1.01–1.22, P = 0.035). For the rs11614913 polymorphism of miR-196a-2, significant increased risks for HCC development were observed when all studies were pooled under four models (C vs T: OR = 1.14, 95% CI = 1.06–1.23, P = 0.001; CC vs TT: OR = 1.31, 95% CI = 1.12–1.53, P = 0.001; CC + TC vs TT: OR = 1.16, 95% CI = 1.03–1.31, P = 0.018; CC vs TC + TT: OR = 1.14, 95% CI = 1.00–1.30, P = 0.043).ConclusionOur results show that the two common SNPs within the miRNAs were associated with modest increased risk of HCC (OR < 1.6), especially in the Asian population. Larger population-based studies validating these results are needed.

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Section: Discussionsupporting

confidence: 88%

Common functional polymorphism within miR-146a and miR-196a-2 as susceptibility loci for hepatocellular carcinoma: An updated meta-analysis

Luo

Xiang

et al. 2016

Meta Gene

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“…29 In a study on the Asian population, It was shown that, the mir196a2 rs11614913 polymorphism seems to contribute to susceptibility to lung cancer risk, diagnosis, screening and therapy. 25,27 In several recent meta-analysis studies, it was found that there is no significant relationship between gastric cancer and mir169a2polymorphism, but in case-control studies in the Egyptian, German and Japanese populations, there was a significant correlation between mir196a2 rs11614913 polymorphism and stomach cancer prognosis. 27 By Comparing other extensive association studies that have been conducted in Asian and European populations with different techniques such as PCR RFLP, Taq man SNP Genotyping and DNA sequencing, on various types of cancer, it confirmed that mir196a2 rs11614913 polymorphism significantly increases the risk of breast and the lung cancer.…”

Section: Discussionmentioning

confidence: 99%

“…24 Moreover, miR155 has been characterized as a component of the primary macrophage response to different types of inflammatory mediators such as IFN-β or Tumor Necrosis Factor-α (TNF-α). [25][26][27][28][29] It has been shown that miR155 is induced by bacterial lipopolysaccharide (LPS) in a human monocytic cell line. 30 Some study in Egyptian population proposed that mir196a2 rs11614913 polymorphism could be associated with asthma severity.…”

Section: Introductionmentioning

confidence: 99%

Genetic Variation in Intergenic and Exonic miRNA Sequence and Risk of Multiple Sclerosis in the Isfahan Patients

Golshani

Hojati

Sharifzadeh

et al. 2018

IJAAI

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MicroRNAs (miRNAs), have been documented to perform a key role in the pathogenesis of multiple sclerosis (MS), a chronic inflammatory and autoimmune disease. Recent studies have shown that single nucleotide polymorphism in the sequence of the miRNA may change their production and expression which can lead to miRNA dysfunction and pathogenicity. Some studies have reported the relationship between miRNA polymorphism and the increased risk of autoimmune disease. This study was conducted to investigate the association between mir155 rs767649, mir196a2 rs11614913 and mir23a rs3745453 polymorphism and the risk of multiple sclerosis in the Iranian MS patients in Isfahan. A population of 80 patients and the same number control were selected. After DNA extraction, genotyping was performed through tetra amplification refractory mutation system-PCR method (T ARMS PCR). The frequencies of TT, TC and CC genotypes of mir23a were 46, 35 and 20% in MS patients and 42, 14 and 24 in healthy subjects respectively. These results showed that individuals carrying the genotypes of rs3745453 TC had a 2.3-fold increased risk of MS (OR=2.3, p=0.048). There was no significant difference between genotypes and allele frequency of mir155 and mir196a2 in patients and healthy controls (p>0.05). Our findings specified that CT heterozygosity in mir23a gene significantly related with risk of MS. Unlike mir155 and mir196a2, mir23a rs3745453 may have contributed to the etiology of MS in Isfahan patients. However, extensive studies are required to gain more reliable and authentic results.

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“…Rs11614913 (T>C) is a common variant in pre-miR-196a2 that plays a role in the development of multiple cancer types, including gastric cancer (Peng et al, 2014;Ni et al, 2015;Nikolić et al, 2015;Qi et al, 2015;Wu et al, 2015). Several studies have evaluated the effect of this polymorphism on gastric cancer risk in different populations, but the results are inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Association between the pre-miR-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population

Bai

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We did a case-control study to provide a more comprehensive evaluation of the association of the pre-miR-196a2 rs11614913 polymorphism with gastric cancer. Between January 2013 and December 2014, 182 patients newly diagnosed with primary gastric cancer and 182 control subjects were recruited at Zhengzhou People's Hospital. For SNP genotyping, we used the Assay Designer 3.1 to design the primers of polymerase chain reaction. Using the chisquare test, we found that patients with gastric cancer were more likely to be alcohol drinkers (c 2 = 4.4, P = 0.04), to have a family history of cancer in the first relatives (c 2 = 5.29, P = 0.02), and to be infected with Helicobacter pylori (c 2 = 23.39, P < 0.001). A significant difference in the genotype distributions of rs11614913 was observed in our study (c 2 = 6.66, P = 0.04). By logistic regression analysis, we found that the CC genotype of rs11614913 was associated with an increased risk of gastric cancer in a codominant model (OR = 2.68, 95%CI = 1.17-6.44). By stratification analysis, we found that the CC genotype was associated with a strongly increased risk of gastric cancer in drinkers when compared with the TT+TC genotype (OR = 5.63, 95%CI = 1.54- 30.76). In conclusion, the results of our study suggest an association between the rs11614913 gene polymorphism and an elevated risk of gastric cancer, especially in drinkers.

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Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility

Cited by 16 publications

References 69 publications

Common functional polymorphism within miR-146a and miR-196a-2 as susceptibility loci for hepatocellular carcinoma: An updated meta-analysis

Common functional polymorphism within miR-146a and miR-196a-2 as susceptibility loci for hepatocellular carcinoma: An updated meta-analysis

Genetic Variation in Intergenic and Exonic miRNA Sequence and Risk of Multiple Sclerosis in the Isfahan Patients

Association between the pre-miR-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population

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