Effects of two cannabinoids upon abstinence signs in ethanol-dependent mice

Sprague, G.L.; Craigmill, Arthur L.

doi:10.1016/0091-3057(78)90005-9

Cited by 12 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two studies report decreased HIC scores in CB1 KO mice following chronic ethanol vapor inhalation (Vinod et al, 2008b) and 4 week forced consumption (Racz et al, 2003) while a third reports enhanced HICs following a 12-day forced consumption paradigm (Naassila et al, 2004). Importantly, Vinod et al (2008b) also observed that the reduction in withdrawal severity could be reconstituted in wt mice by treating them with SR. Taken in the context of earlier studies reporting increased withdrawal severity following administration of CB1 agonists (Kralik et al, 1976; Sprague and Craigmill, 1978), these results suggest a positive correlation between CB1 activation and HIC severity. However, these early studies used THC, a full CB1 agonist, to enhance withdrawal severity, and in addition to the potential confounds associated with using CB1 agonists to modulate HIC measures (see historical perspectives section), these studies reported differential findings based on the measure of withdrawal.…”

Section: Ethanol and The Ec Systemsupporting

confidence: 79%

“…When compared with controls, mice undergoing ethanol withdrawal startle when a lower voltage is applied the cage floor. Using this measure of withdrawal severity, Sprague and Craigmill (1978) found that acute administration of THC, nabilone, or ethanol similarly ameliorated the decreased startle threshold during withdrawal from chronic vapor treatment.…”

Section: Historical Perspectivesmentioning

confidence: 97%

“…Preclinical studies, however, dispute the beneficial effects of cannabinoid administration on ethanol withdrawal symptoms. Acute administration of THC to mice given three days of continuous ethanol vapor treatment produced higher handling-induced convulsion (HIC) scores and a longer duration withdrawal than subjects given vehicle upon removal from the chambers (Kralik et al, 1976; Sprague and Craigmill, 1978). One potential caveat to these studies is that acute administration of CB1 agonists can generate hyper-reflexive responses that manifest as eccentric jumping when the animal is slightly perturbed (Dewey, 1986; Patel and Hillard, 2001).…”

Section: Historical Perspectivesmentioning

confidence: 99%

See 2 more Smart Citations

A review of the interactions between alcohol and the endocannabinoid system: Implications for alcohol dependence and future directions for research

Pava

Woodward

2012

Alcohol

131

101

View full text Add to dashboard Cite

Over the past fifty years a significant body of evidence has been compiled suggesting an interaction between the endocannabinoid (EC) system and alcohol dependence. However, much of this work has been conducted only in the past two decades following the elucidation of the molecular constituents of the EC system that began with the serendipitous discovery of the cannabinoid 1 receptor (CB1). Since then, novel pharmacological and genetic tools have enabled researchers to manipulate select components of the EC system, to determine their contribution to the motivation to consume ethanol. From these preclinical studies, it is evident that CB1 contributes the motivational and reinforcing properties of ethanol, and chronic consumption of ethanol alters EC transmitter levels and CB1 expression in brain nuclei associated with addiction pathways. These results are augmented by in vitro and ex vivo studies showing that acute and chronic treatment with ethanol produces physiologically relevant alterations in the function of the EC system. This report provides a current and comprehensive review of the literature regarding the interactions between ethanol and the EC system. We begin be reviewing the studies published prior to the discovery of the EC system that compared the behavioral and physiological effects of cannabinoids with ethanol in addition to cross-tolerance between these drugs. Next, a brief overview of the molecular constituents of the EC system is provided as context for the subsequent review of more recent studies examining the interaction of ethanol with the EC system. These results are compiled into a summary providing a scheme for the known changes to the components of the EC system in different stages of alcohol dependence. Finally, future directions for research are discussed.

show abstract

Section: Ethanol and The Ec Systemsupporting

confidence: 79%

Section: Historical Perspectivesmentioning

confidence: 97%

Section: Historical Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

A review of the interactions between alcohol and the endocannabinoid system: Implications for alcohol dependence and future directions for research

Pava

Woodward

2012

Alcohol

131

101

View full text Add to dashboard Cite

show abstract

“…Thus, Δ9‐THC ameliorates the severity of naloxone‐precipitated somatic signs of morphine withdrawal in mice (Manzanares et al ., 1999). In addition, Δ9‐THC also alleviated some manifestations of ethanol abstinence in mice (Sprague & Craigmill, 1978).…”

Section: Discussionmentioning

confidence: 99%

“…Finally, the consequences of Δ9‐THC administration on the aversive motivational state associated with nicotine withdrawal were also evaluated. Similar studies have been previously conducted with other drugs of abuse, such as opioids (Manzanares et al ., 1999) and alcohol (Sprague & Craigmill, 1978), that also interact with cannabinoids.…”

Section: Introductionmentioning

confidence: 99%

Δ9‐tetrahydrocannabinol decreases somatic and motivational manifestations of nicotine withdrawal in mice

Balerio¹,

Aso²,

Berrendero³

et al. 2004

Eur J of Neuroscience

105

View full text Add to dashboard Cite

The possible interactions between Δ9-tetrahydrocannabinol (THC) and nicotine remain unclear in spite of the current association of cannabis and tobacco in humans. The aim of the present study was to explore the interactions between these two drugs of abuse by evaluating the consequences of THC administration on the somatic manifestations and the aversive motivational state associated to nicotine withdrawal in mice. Acute THC administration significantly decreased the incidence of several nicotine withdrawal signs precipitated by mecamylamine or naloxone, such as wet-dog-shakes, paw tremor and scratches. In both experimental conditions, the global withdrawal score was also significantly attenuated by acute THC administration. THC also reversed conditioned place aversion associated to naloxone precipitated nicotine withdrawal. We have then

show abstract