Effects of two antihistamine drugs on actual driving performance.

Betts, Tim; Markman, D; Debenham, S; Mortiboy, D.; McKevitt, T

doi:10.1136/bmj.288.6413.281

Cited by 62 publications

(27 citation statements)

References 3 publications

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“…Betts et al [ 12] found that being aware o f deterioration in driving due to drowsiness from a centrally acting anti histamine cannot be compensated for. Although past research looking at C N S effects has not shown significant changes using diphenhydramine in 50-mg doses, the P R EP did show C N S changes.…”

Section: Subjective Feelingsmentioning

confidence: 99%

“…In a study comparing a centrally acting antihistamine, triprolidine (in the same class as diphenhydramine), and a peripherally acting antihistamine, terfenadine, on actual driving performance, triprolidine significantly impaired driving while terfenadine did not [12]. Specifically, time to complete the driving course and the number o f driving errors increased, as well as the inability to negotiate nar row passages.…”

mentioning

confidence: 99%

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Antihistamine Effects on the Central Nervous System, Cognitive Performance and Subjective States

1994

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Diphenhydramine causes drowsiness and performance decrements in some tasks whereas terfenadine generally does not. This study examined central nervous system (CNS) differences in response to the administration of diphenhydramine (50 mg) and terfenadine (60 mg) up to 3 h after drug administration. Two evoked potential measures, the Brainstem Auditory Evoked Potential and the Pattern Reversal Evoked Potential (PREP), assessed CNS function. Other measures of CNS function, cognitive performance and subjective states administered included Critical Flicker Fusion, the Baddeley Grammatical Reasoning Test, Digit Symbol Substitution, the Profile of Mood States, and the Environmental Symptoms Questionnaire. Significant increases in PREP latencies (N75, P100 and N145) occurred after orally ingesting diphenhydramine. No other significant drug effects were observed. The significant increase in the PREP latencies indicate diphenhydramine’s presence in the cerebral cortex results in a slowing of visual information processing. The lack of significant findings for terfenadine is probably a result of its difficulty in penetrating the blood-brain barrier.

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Section: Subjective Feelingsmentioning

confidence: 99%

mentioning

confidence: 99%

Antihistamine Effects on the Central Nervous System, Cognitive Performance and Subjective States

1994

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“…Whereas enhancement of sleep at night by promethazine 20 mg is paralleled by impaired daytime psychomotor function after a 25 mg dose (Hindmarch & Parrott, 1978), it may be predicted from our present negative findings that daytime psychomotor testing with temelastine 100 mg would fail to show impairment. It is noteworthy that terfenadine, a histamine Hl-receptor antagonist, has been reported not to speed sleep onset (Roehrs et al, 1984), nor to cause impairment on a daytime driving task (Betts et al, 1984).…”

Section: Methodsmentioning

confidence: 99%

No effects on sleep of a histamine H1‐receptor antagonist: temelastine.

Adám¹,

Oswald²

1986

Brit J Clinical Pharma

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“…Tripolidine has been shown to impair driving behavior, as well as causing subjective and objective measures of mood and arousal [4]. Reports on performance showed that reaction time was prolonged.…”

Section: Introductionmentioning

confidence: 99%

Comparison of CNS Adverse Effects between Astemizole and Chlorpheniramine in Children: A Randomized, Double-Blind Study

Shanon

Feldman²,

Leikin³

et al. 1993

Dev Pharmacol Ther

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Objective. To assess the central nervous system side effects of chlorpheniramine and astemizole in children. Design. Prospective, randomized, double- blind cross-over study. Setting. Children were recruited from the outpatient allergy clinic and from respondents to an advertisement in a local newspaper. The study was conducted in the outpatient clinics of the ambulatory care services of the Children’s Hospital of Eastern Ontario. Patients, Participants. Children 8-16 years of age, with isolated allergic rhinitis or hay fever, were eligible for the study. We excluded children with: (1) chronic conditions (specifically asthma, atopic dermatitis, learning disabilities, or current treatment with oral corticosteroid medication); (2) known allergy to the study medications; (3) recent use of any antihistamine medication. One hundred and three children entered the study and 92 completed it. Interventions. Children were stratified by age and randomly allocated to treatment with one of the two medication sequences. Over a period of 13 weeks both groups had 1 week of baseline studies, 3 weeks of one study medication, either chlorpheniramine or astemizole, a 6-week wash-out period and then 3 weeks of the other study medication for a second treatment period. Main Outcome Measures. Attention span (continuous performance test), short-term auditory and visual memory (visual aural digit span test), visual memory for geometric shapes (Benton visual retention test), motor coordination and visual-motor integration (grooved pegboard test), tapping speed and fine motor coordination (finger tapping test), physical side effects (such as sleepiness and dizziness), and compliance. Results. One hundred and three patients were enrolled in the study, 92 (89%) completed the study. There were no significant drug effects on the visual retention test and the continuous performance test. On the visual aural digit span test, patients treated with astemizole scored higher than at baseline. There were no clinical or statistical differences in adverse effects between the two medications or between each medication and baseline. Conclusions. The two antihistamines studied had no adverse effects on the performance of children.

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Effects of two antihistamine drugs on actual driving performance.

Cited by 62 publications

References 3 publications

Antihistamine Effects on the Central Nervous System, Cognitive Performance and Subjective States

Antihistamine Effects on the Central Nervous System, Cognitive Performance and Subjective States

No effects on sleep of a histamine H1‐receptor antagonist: temelastine.

Comparison of CNS Adverse Effects between Astemizole and Chlorpheniramine in Children: A Randomized, Double-Blind Study

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