Effects of twelve weeks of aerobic or strength training in addition to standard care in Parkinson's disease: a controlled study

Demonceau, Marie; Maquet, Didier; Jidovtseff, Boris; Donneau, Anne‐Françoise; Bury, Thierry; Croisier, Jean-Louis; Crielaard, Jean-Michel; Cruz, Carlos Rodriguez de la; Delvaux, Valérie; Garraux, Gaëtan

doi:10.23736/s1973-9087.16.04272-6

Cited by 32 publications

(76 citation statements)

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“…More males than females were enrolled, mean age was 65 years, and mean duration of PD was 6.0 years. Thirtyone studies 5,[16][17][18][19][20][21][22][23][24]26,28,[30][31][32][33][44][45][46][47][48] fully supervised the training interventions, one study 29 supervised the first two weeks of the intervention only, two studies 49,50 performed remote supervision, and one study 25 did not report on this.…”

Section: Study Inclusionmentioning

confidence: 99%

“…adverse event was related to the intervention (1 due to a light knee sprain at the end of the last session following aerobic training, 18 3 due to discomfort while performing an RT exercise during a session 47 ). Additional adverse events were unrelated to the interventions across four studies (5 due to aggravation of pre-existing injuries, 17,18 2 due to problems with internal organs, 29 8 (RT: 6, ET:…”

Section: Safetymentioning

confidence: 99%

“…2) due to headache/tiredness/hypotension/patella pain syndrome or back pain 18 ) and 7 due to vestibular disorder, vasovagal collapse, knee injury, supraventricular tachycardia, hip fracture, fall-related injury, and severe dyskinesias 49 ). Other than this, no serious symptom exacerbations or deterioration in any outcome parameters were reported (Tables 1-5).…”

Section: Safetymentioning

confidence: 99%

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Parkinson’s disease and intensive exercise therapy — An updated systematic review and meta‐analysis

Gamborg

Hvid

Dalgas

et al. 2022

Acta Neuro Scandinavica

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In 2015, Uhrbrand et al. published the first review on Parkinson´s disease (PD) and exercise entirely based on randomized controlled trials (RCT) applying strict exercise definitions. The present review aimed to update the PD literature by assessing the effects of different intensive exercise modalities: resistance training (RT), endurance training (ET), and other intensive exercise modalities (OITM). An updated systematic literature search identified 33 new RCTs. Qualitative and quantitative analyses were performed. A total of 18 RT, 14 ET, and 1 OITM studies were identified (adding to the 8 RT, 6 ET, and 4 OITM studies identified by Uhrbrand et al. in 2015). RT, ET, and OITM were feasible, safe, and did not worsen PD symptoms. Furthermore, RT, ET, and OITM may positively affect functional outcomes (e.g., balance) and depressive symptoms in PD but inconsistencies across these findings warrant cautious conclusions. Meta-analyses showed that RT had a positive impact on muscle strength (standardized mean difference (SMD) = 0.83 [95% CI;0.54, 1.12]), functional capacity (Timed Up and Go Test (TUG): SMD = −0.62 [−1.01, −0.24]), and quality of life (SMD = −0.41 [−0.72, −0.09]), while ET had a positive impact on cardiorespiratory fitness (SMD = 0.27 [0.07, 0.47]) and functional capacity (TUG: SMD = −0.21 [−0.46, 0.04], 6-Min Walk Test: SMD = 0.89 [0.17, 1.62]), and a potentially positive impact on "on-medication" UPDRS-III (SMD = −0.15 [−0.38, 0.09]) and "off-medication" UPDRS-III (SMD = −0.19 [−0.41, 0.04]). In conclusion, RT, ET, and OITM all represent safe, feasible, and beneficial adjunct rehabilitation strategies in PD, with particularly RT and ET showing solid effects.

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Section: Study Inclusionmentioning

confidence: 99%

Section: Safetymentioning

confidence: 99%

Section: Safetymentioning

confidence: 99%

See 1 more Smart Citation

Parkinson’s disease and intensive exercise therapy — An updated systematic review and meta‐analysis

Gamborg

Hvid

Dalgas

et al. 2022

Acta Neuro Scandinavica

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“…Studies have examined aerobic capacity in subjects with PD [ 44 , 45 , 46 ]. Interestingly, Canning [ 47 ] reported no correlation between disease severity and VO 2 peak in individuals with mild to moderate PD while VO 2 peak values were found generally 20% lower than age-matched controls without PD studied [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a recent review [ 46 ] on the most suitable clinical exercise testing in PD, the authors cited the 6MWT test as an important field test. The 6MWT test was used as an outcome measure after treadmill training [ 49 ] or limb strength training, as well as aerobic training and incremental aerobic cycling [ 45 ]. In both papers, distance walked was lower than predicted before, but improved after, rehabilitation.…”

Section: Discussionmentioning

confidence: 99%

Exercise Intolerance and Oxygen Desaturation in Patients with Parkinson’s Disease: Triggers for Respiratory Rehabilitation?

Vitacca

Olivares

Comini

et al. 2021

IJERPH

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The role that oxygen desaturation plays in exercise tolerance and its rehabilitative implications in patients with Parkinson’s disease (PD) are unclear. We aimed to test exercise tolerance and oxygen saturation levels both during exercise and at night in PD patients to better define their rehabilitative needs. In clinically stable PD patients, undergoing inpatient rehabilitation, and in “ON” phase, we prospectively assessed clinical data, sleepiness, comorbidities, PD severity (Hoehn&Yahr, HY), motor function (ADLs, UPDRSII and UPDRSIII, Barthel Index, Functional Independence Measure), balance, spirometry, respiratory muscles (MIP/MEP), peak cough expiratory flow (PCEF), continuous night oxygen monitoring, and meters at 6MWT. Of 55 patients analyzed (28 with moderate–severe PD, HY ≥ 2.5), 37% and 23% showed moderate–severe impairment on UPDRSII and UPDRSIII, respectively; 96% had reduced exercise tolerance and severe respiratory muscles impairment (MIP/MEP < 45% pred.); 21.8% showed desaturations during exercise; and 12.7% showed nocturnal desaturations. At multiple regression, low exercise tolerance and low mean nocturnal and exercise-induced saturation correlated with several respiratory and motor function and disability indices (all p < 0.03). Exercise tolerance, exercise-induced desaturations, and nocturnal desaturations were extremely frequent in PD patients and were worse in more severe PD patients. This suggests considering a combined role for motor and respiratory rehabilitation in these patients.

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The effects of exercise dose on patients with Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials

Cui,

Li,

Yue

et al. 2023

J Neurol

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Effects of twelve weeks of aerobic or strength training in addition to standard care in Parkinson's disease: a controlled study

Cited by 32 publications

References 0 publications

Parkinson’s disease and intensive exercise therapy — An updated systematic review and meta‐analysis

Parkinson’s disease and intensive exercise therapy — An updated systematic review and meta‐analysis

Exercise Intolerance and Oxygen Desaturation in Patients with Parkinson’s Disease: Triggers for Respiratory Rehabilitation?

The effects of exercise dose on patients with Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials

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