Effects of turmeric extract supplementation on the lipid and lipoprotein subfraction profile in hemodialysis patients: A randomised, double‐blind, crossover and controlled trial

Abstract

Dyslipidemia is common in patients with chronic kidney disease. Curcumin, a bioactive polyphenol from Curcuma longa, can improve lipid profile. This study aims to analyze the effects of Curcuma Longa extract supplementation on lipid profile and lipoprotein subfractions in hemodialysis (HD) patients. This is a longitudinal, double‐blind, washout‐period randomized clinical trial. The patients were randomized into two groups: the curcumin group (n = 10) (orange and carrot juice with 2.5 g of Curcuma Longa extract) and the control group (n = 11) (juice without curcumin) 3x/w during HD sessions for 3 months. After the washout period, patients continued the supplementation as a crossover for the same period. The lipid profile was measured using enzymatic assays. The high‐density lipoprotein and low‐density lipoprotein subfractions analyses were performed using LipoprintTM. In the curcumin group, the triglyceride values tended to decrease with a different triglyceride variation between the pre and post‐intervention for the control and curcumin groups of 38.5 (19.8) mg/dL (p = 0.06). There was no statistical difference in the others parameters. In conclusion, Curcuma longa extract may be a good nutritional strategy to reduce triglyceride plasma levels in hemodialysis patients, but it seems ineffective for the other parameter.

The effects of powdered drinks enriched with curcumin and probiotics on lipid profile and atherogenic indices in patients with metabolic syndrome: A randomized, double‐blinded, placebo‐controlled clinical trial

“…Nonetheless, in some animal and human studies, supplementation with curcumin led to improvements in lipid profiles and some atherogenic indicators (Ghelani et al., 2019 ; Qin et al., 2017 ; Yang et al., 2014 ). Also, in a recently published study, curcumin extract in carrot and orange mixed drinks reduced triglyceride levels in hemodialysis patients but had no effect on other lipid profile parameters (Alvarenga et al., 2023 ). Curcumin is thought to improve the lipid profile through different mechanisms, as follows.…”