Effects of tumour stage, comorbidity and therapy on survival of laryngeal cancer patients: a systematic review and a meta-analysis

Rudolph, Elisabeth; Dyckhoff, Gerhard; Becher, Heiko; Dietz, Andreas; Ramroth, Heribert

doi:10.1007/s00405-010-1395-8

Cited by 107 publications

(77 citation statements)

References 68 publications

(148 reference statements)

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“…aryngeal carcinoma (LC) is the second most common cancer of the respiratory tract, and the overall 5-year relative survival rate is approximately 64.2% (1,2). Treatments for laryngeal cancer include surgery, radiotherapy, chemotherapy, and biological agents, which can be used either individually or in combination (3,4).…”

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confidence: 99%

Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma

Gong

Shi

Zhou

et al. 2014

Appl Environ Microbiol

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The compositions and abundances of the microbiota in the ecological niche of the human throat and the possible relationship between the microbiota and laryngeal cancer are poorly understood. To obtain insight into this, we enrolled 27 laryngeal carcinoma patients and 28 subjects with vocal cord polyps as controls. For each subject, we simultaneously collected swab samples from the upper throat near the epiglottis (site I) and tissue samples from the vestibulum laryngis to the subglottic region (site II). The microbiota of the throat were fully characterized by pyrosequencing of barcoded 16S rRNA genes. We found 14 phyla, 20 classes, 38 orders, 85 families, and 218 genera in the throats of enrolled subjects. The main phyla were Firmicutes (54.7%), Fusobacteria (14.8%), Bacteroidetes (12.7%), and Proteobacteria (10.6%). Streptococcus (37.3%), Fusobacterium (11.3%), and Prevotella (10.6%) were identified as the three most predominant genera in the throat. The relative abundances of 23 bacterial genera in site I were significantly different from those in site II (P < 0.05). The relative proportions of 12 genera largely varied between laryngeal cancer patients and control subjects (P < 0.05). Collectively, this study outlined the spatial structure of microbial communities in the human throat. The spatial structure of bacterial communities significantly varied in two anatomical sites of the throat. The bacterial profiles of the throat of laryngeal cancer patients were strongly different from those of control subjects, and several of these microorganisms may be related to laryngeal carcinoma.

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confidence: 99%

Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma

Gong

Shi

Zhou

et al. 2014

Appl Environ Microbiol

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“…Larynx cancer is the second most common malignancy of the respiratory tract and of all head and neck cancers [1,2], with glottic carcinoma the most common type [3]. To date the majority of research on voice outcomes following early glottic cancer (Tis-T2) has explored the impact of either radiotherapy or transoral laser microsurgery on voice quality and functional outcomes [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

The impact of laryngeal biopsy on voice outcomes: a pilot study

Bergström¹,

Ward²,

Finizia³

2016

Otorhinolaryngol Head Neck Surg

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Objective: Several studies have suggested that type of laryngeal biopsy may impact voice and vocal function, which may ultimately influence functional outcomes post cancer treatment. This study directly examined the impact of the biopsy procedure on voice outcomes for early glottic (Tis-T2) cancer patients.Design: Prospective pilot cohort study. Method:Fifteen patients diagnosed with early glottic cancer underwent voice recordings within one week pre-biopsy and between one-six weeks post-biopsy, via Sahlgrenska University Hospital, Sweden. A control group (n=15), matched for gender and comparable for age and smoking status, was assessed once only. Multidimensional voice analyses were conducted with both groups including: (1) Grade, Roughness, Breathiness, Asthenia, Strain (GRBAS) perceptual rating, (2) acoustic measures of harmonics to noise ratio, jitter, shimmer, mean spoken fundamental frequency and (3) Maximum Phonation Time (MPT). Results:In comparison to the control group, most perceptual and acoustic parameters were significantly (P<0.05) more impaired both pre and post biopsy. No significant difference (P>0.05) in the patient cohort was observed between pre-post biopsy voice parameters. At an individual level, half of the patients showed a perceived change in voice post biopsy, of which four demonstrated improvement and three a deterioration in vocal function. Implications:Although group level analysis did not show a significant biopsy-voice impact, individual data suggests that multiple, punch biopsies may negatively impact functional outcomes. The biopsy procedure is undoubtedly a necessary first step in laryngeal cancer management; however, given the emerging discussion regarding the type of biopsy technique, the nature and the extent of tumour/tissue removal on functional outcomes, this is an area for further research.

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“…Lymph node metastasis is common in supraglottic carcinoma and is the main cause of mortality for these patients. It has been reported that the incidence of lymph node metastasis may be as high as 25-50% in supraglottic carcinoma (1). Current treatments, including surgical intervention, radiation therapy and chemotherapy, have a moderate effect on early-stage cases, but are less effective in more advanced cases.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA expression profiles in supraglottic carcinoma

et al. 2014

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Abstract. MicroRNAs (miRNAs) are single-stranded RNA molecules which regulate gene expression at the post-transcriptional level and several miRNAs have been found to be associated with some types of cancer. We sought to identify the expression and involvement of miRNAs in supraglottic carcinoma tissues compared with normal tissues and to determine whether miRNA expression is predictive of disease. Unsupervised clustering shows that miRNA profiles can distinguish tumor from normal tissues. Analysis of miRNA contents in supraglottic carcinoma highlighted nineteen differentially expressed miRNAs, three upregulated miRNAs (miR-21, miR-19a, miR-33a) and two downregulated miRNAs (miR-206, miR-375). The microarray results of supraglottic carcinoma and related computer analysis may be beneficial for further analysis of cancer diagnosis and therapy. IntroductionLaryngeal squamous cell carcinoma (LSCC) is a very common malignant neoplasm of the head and neck. One of the key challenges in the treatment of LSCC is the management of metastasis to locoregional lymph nodes. Lymph node metastasis is common in supraglottic carcinoma and is the main cause of mortality for these patients. It has been reported that the incidence of lymph node metastasis may be as high as 25-50% in supraglottic carcinoma (1). Current treatments, including surgical intervention, radiation therapy and chemotherapy, have a moderate effect on early-stage cases, but are less effective in more advanced cases. Five-year overall survival for supraglottic cancer remains poor (2,3). Therefore, understanding the molecular pathways of carcinogenesis or progression is key to improving diagnosis, therapy and prevention of supraglottic carcinoma. microRNAs (miRNAs) are a class of small, non-coding RNAs that are endogenously expressed in animal and plant cells. They regulate the expression of protein-coding genes at the translational level. One strand of the mature double-stranded miRNA is incorporated into the RNA-induced silencing complex, which downregulates target mRNAs either by degradation or by translational inhibition (4). miRNAs play important roles in normal regulation of gene expression for developmental timing, cell proliferation and apoptosis. Moreover, altered miRNA expression is implicated in cancer. Recently, miRNA genes were implicated in several types of cancer (5-7). The expression of miRNAs varies between cancer and normal cells and it also varies among different types of cancer. It has been shown that some miRNAs are aberrantly expressed in several different types of cancer (8-10), suggesting that they may play a role as a novel class of oncogenes or tumor-suppressor genes.Several target genes have been experimentally identified for some miRNAs in various LSCCs; however, the global pattern of cellular functions and pathways affected by miRNAs in supraglottic cancer remains elusive. In the present study, expression profiling of miRNAs in clinical supraglottic carcinoma tissue samples was carried out, revealing the relationship between miRNA exp...

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Effects of tumour stage, comorbidity and therapy on survival of laryngeal cancer patients: a systematic review and a meta-analysis

Cited by 107 publications

References 68 publications

Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma

Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma

The impact of laryngeal biopsy on voice outcomes: a pilot study

MicroRNA expression profiles in supraglottic carcinoma

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