Effects of Tualang honey in modulating nociceptive responses at the spinal cord in offspring of prenatally stressed rats

Aziz, Che Badariah Abd; Suhaimi, Siti Qusyasyiah Ahmad; Hasim, Hidani; Ahmad, Asma Hayati; Long, Idris; Zakaria, Rahimah

doi:10.1016/j.joim.2018.12.002

Cited by 16 publications

(15 citation statements)

References 43 publications

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“…Moreover, its antinociceptive effect was found to be more effective than vitamin C (20 mg/kg) as revealed by the lower pain behaviour responses in another study that also used formalin-induced inflammatory rat model [ 72 ]. Taken together, these investigators propose that the analgesic and antinociceptive effects of Tualang honey are attributed to its action on opioid receptors in the spinal cord and its interaction at the level of glutamate receptors in the central nervous system [ 73 ].…”

Section: Resultsmentioning

confidence: 99%

“…The antinociceptive effect of Tualang honey could be derived from its constituents such as gallic acid, as gallic acid attenuates nitric oxide synthase, COX-2, histamine, and pro-inflammatory cytokines released by macrophage [ 74 ]. Moreover, the anti-inflammatory properties of Tualang honey should also facilitate its antinociceptive effects as it promotes the extravasation of neutrophils at the injured site and reduces pro-inflammatory cytokines (e.g., interleukin 6) in blood serum during the course of inflammatory pain [ 73 ]. Compared to vitamin C supplementation, the effectiveness of Tualang honey in minimizing pain responses is possibly contributed by its antioxidant effects as it increases the activity of serum catalase (116.11 ng/mL in honey-supplemented rat compared to 82.05 ng/mL in control rat) and superoxide dismutase (SOD) (94.91 pg/mL in honey-treated rat compared to 46.76 pg/mL in control rat) [ 73 ].…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the anti-inflammatory properties of Tualang honey should also facilitate its antinociceptive effects as it promotes the extravasation of neutrophils at the injured site and reduces pro-inflammatory cytokines (e.g., interleukin 6) in blood serum during the course of inflammatory pain [ 73 ]. Compared to vitamin C supplementation, the effectiveness of Tualang honey in minimizing pain responses is possibly contributed by its antioxidant effects as it increases the activity of serum catalase (116.11 ng/mL in honey-supplemented rat compared to 82.05 ng/mL in control rat) and superoxide dismutase (SOD) (94.91 pg/mL in honey-treated rat compared to 46.76 pg/mL in control rat) [ 73 ]. The antioxidant properties contribute to the overall antinociceptive and antidepressant effects of Tualang honey ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

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Tualang Honey: A Decade of Neurological Research

et al. 2021

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Tualang honey has been shown to protect against neurodegeneration, leading to improved memory/learning as well as mood. In addition, studies have also demonstrated its anti-inflammatory and antioxidant properties. However, a substantial part of this research lacks systematization, and there seems to be a tendency to start anew with every study. This review presents a decade of research on Tualang honey with a particular interest in the underlying mechanisms related to its effects on the central nervous system. A total of 28 original articles published between 2011 and 2020 addressing the central nervous system (CNS) effects of Tualang honey were analysed. We identified five main categories, namely nootropic, antinociceptive, stress-relieving, antidepressant, and anxiolytic effects of Tualang honey, and proposed the underlying mechanisms. The findings from this review may potentially be beneficial towards developing new therapeutic roles for Tualang honey and help in determining how best to benefit from this brain supplement.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Tualang Honey: A Decade of Neurological Research

et al. 2021

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“…Additionally, both enzymatic and nonenzymatic antioxidant contents in honey may act at different cellular levels, by preventing oxidation of the macromolecules or stimulating gene expressions, which ultimately provoke an antioxidant response [31, 34]. Offsprings of rats fed with Tualang honey also had a higher GSH level and a lower lipid peroxidation level in their spinal cord tissue after being challenged with formalin-induced stress [35]. Apart from interacting with oxidants physically, polyphenols in honey can activate intracellular signalling cascades, such as phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), protein kinase B (PKB)/Akt, tyrosine kinases, protein kinase C (PKC), and mitogen-activated protein kinases (MAPKs) [36].…”

Section: Antioxidant Properties Of Honeymentioning

confidence: 99%

A Review of Potential Beneficial Effects of Honey on Bone Health

Kamaruzzaman

Chin

Ramli

2019

Evidence-Based Complementary and Alternative Medicine

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Bone remodelling is a complex and tightly regulated process. Disruption of bone remodelling skewing towards resorption will cause osteoporosis and increase the risk of fragility fracture. Honey is a natural product containing various bioactive ingredients with health benefits, especially polyphenols. Therefore, honey may be a novel dietary supplement to prevent osteoporosis. This review aims to summarize the current evidence on the effects of honey on bone health. The evidence reported so far indicates a skeletal-beneficial effect of honey in animal models of osteoporosis. However, the number of studies on humans is limited. Honey can protect the bone via its antioxidant and anti-inflammatory properties, primarily through its polyphenol content that acts upon several signalling pathways, leading to bone anabolic and antiresorptive effects. In conclusion, honey is a potential functional food for bone health, but the dose and the bioactive contents of honey need to be verified prior to its application in humans.

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“…suggest that honey provides neuroprotective and nootropic effects. Honey possesses a memory-enhancing effect [10] and anxiolytic, antinociceptive [11, 12], anticonvulsant, and antidepressant effects [12] and has potential to improve the oxidative status of the brain [13, 14]. The nootropic effects of honey supplementation were observed in the development of the brain in infants and demonstrated improvements in memory and intellectual performance of children [15].…”

Section: Introductionmentioning

confidence: 99%

Stingless Bee Honey Improves Spatial Memory in Mice, Probably Associated with Brain-Derived Neurotrophic Factor (BDNF) and Inositol 1,4,5-Triphosphate Receptor Type 1 (Itpr1) Genes

Mustafa

Zulkifli

Fernandez

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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This study was conducted to evaluate the effects of stingless bee honey (SBH) supplementation on memory and learning in mice. Despite many studies that show the benefits of honey on memory, reports on the nootropic effects of SBH are still lacking, and their underlying mechanism is still unclear. SBH is a honey produced by the bees in the tribe of Meliponini that exist in tropical countries. It features unique storage of honey collected in cerumen pots made of propolis. This SBH may offer a better prospect for therapeutic performance as the previous report identifies the presence of antioxidants that were greater than other honey produced by Apis sp. In this study, SBH was tested on Swiss albino mice following acute (7 days) and semichronic (35 days) supplementation. Experiments were then conducted using Morris water maze (MWM) behaviour analysis, RT-PCR for gene expression of mice striatum, and NMR for metabolomics analysis of the honey. Results indicate spatial working memory and spatial reference memory of mice were significantly improved in the honey-treated group compared with the control group. Improved memory consolidations were also observed in prolonged supplementation. Gene expression analyses of acutely treated mice demonstrated significant upregulation of BDNF and Itpr1 genes that involve in synaptic function. NMR analysis also identified phenylalanine, an essential precursor for tyrosine that plays a role at the BDNF receptor. In conclusion, SBH supplementation for seven days at 2000 mg/kg, which is equivalent to a human dose of 162 mg/kg, showed strong capabilities to improve spatial working memory. And prolonged intake up to 35 days increased spatial reference memory in the mice model. The phenylalanine in SBH may have triggered the upregulation of BDNF genes in honey-treated mice and improved their spatial memory performance.

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Effects of Tualang honey in modulating nociceptive responses at the spinal cord in offspring of prenatally stressed rats

Cited by 16 publications

References 43 publications

Tualang Honey: A Decade of Neurological Research

Tualang Honey: A Decade of Neurological Research

A Review of Potential Beneficial Effects of Honey on Bone Health

Stingless Bee Honey Improves Spatial Memory in Mice, Probably Associated with Brain-Derived Neurotrophic Factor (BDNF) and Inositol 1,4,5-Triphosphate Receptor Type 1 (Itpr1) Genes

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