Effects of troglitazone on dexamethasone-induced insulin resistance in rats

Okumura, Shoji; Takeda, Noriyuki; Takami, Kazuhisa; Yoshino, Kouji; Hattori, Junko; Nakashima, Kazuya; Sugimoto, Miyuki; Ishimori, Masatoshi; Takami, Rieko

doi:10.1016/s0026-0495(98)90270-0

Cited by 21 publications

(22 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of troglitazone to prevent insulin resistance in peripheral tissue has also been reported recently in rats treated with low dose (0.05 mg/ kg/day ) dexamethasone [26]. This effect was not observed in those treated with high dose (0.1 mg/ kg/day) dexamethasone [26] . Insulin resistance induced by dexamethasone (2.5 mg/kg/day) has also been reported recently to be ameliorated by another antidiabetic agent, metformin, without changing the amount of GLUTs [27].…”

Section: Discussionmentioning

confidence: 57%

“…Decreased Gu by skeletal muscles in rats fed with dexamethasone (0.1 mg/kg/day) was ameliorated by pioglitazone administration without changing the amount of glucose transporter (GLUT) 4 [25]. The effect of troglitazone to prevent insulin resistance in peripheral tissue has also been reported recently in rats treated with low dose (0.05 mg/ kg/day ) dexamethasone [26]. This effect was not observed in those treated with high dose (0.1 mg/ kg/day) dexamethasone [26] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Thiazolidinediones Exert Difterent Effects on Insulin Resistance between Dexamethasone-Treated Rats and Wistar Fatty Rats.

et al. 2000

View full text Add to dashboard Cite

Abstract.We determined the in vivo effects of thiazolidinediones on insulin resistance induced by dexamethasone (Dx), as well as that observed in Wistar fatty (WF) rats, using glucose clamp technique to measure glucose uptake (Gu) and percent suppression of hepatic glucose output (HGOsup) to evaluate insulin resistance. Male Wistar rats were treated with Dx (0.5 mg/kg/day) for 7 days. Pioglitazone (P) or troglitazone (T) was coadministered orally for the same period at 10 and 200 mg/kg/day, respectively. Two, 5 and 20 mU/kg/min. of insulin infusion rates (IIR) were used. The Gu levels at clamp steady-state at IIR20 in rats treated with Dx (16.4±4.7 mg/kg/min.) were significantly lower than those in control rats (36.3±2.4).The Gu levels at the same IIR in rats coadminstered with P (19.6±3.2) and T (21.3 ±6.3) were slightly but significantly higher than that in rat treated with Dx. HGOsup at IIR5 in control rats (97.5 ± 6.2%) was decreased by Dx treatment (52.1 ± 31.3). This decrease was slightly but significantly ameliorated by addition of T (78.3±12.2).The Gu levels at IIR20 in WF rats (6.6±0.9) were decreased significantly from that in lean littermates of WF (WL) rats (25.8±2.1).This attenuation of Gu increase was completely ameliorated with administration of P (20.9±2.8) or T (22.2±3.9). The HGOsup at IIR20 in WF rats (17.4±11.2) was significantly decreased from that in WL rats. Administration of P or T ameliorated this decrease completely. These results indicate that Dx induces insulin resistance by mechanisms different from those in WF rat, hence thiazolidinedione administration can be only partially useful to treat insulin resistance induced by Dx.

show abstract

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Thiazolidinediones Exert Difterent Effects on Insulin Resistance between Dexamethasone-Treated Rats and Wistar Fatty Rats.

et al. 2000

View full text Add to dashboard Cite

show abstract

“…Diabetes in patients receiving glucocorticoids is difficult to control and often requires very high doses of insulin. TZDs have been tested as a therapeutic strategy for glucocorticoid-induced diabetes in humans(51)(52) and rodents(53)(54). The underlying mechanisms of how TZDs exert their beneficial effects might be multifactorial buthave not yet been clarified.…”

mentioning

confidence: 99%

Thiazolidinediones attenuate lipolysis and ameliorate dexamethasone-induced insulin resistance

Kuang

et al. 2015

Metabolism

View full text Add to dashboard Cite

“…Metformin/Pioglitazone would have been an ideal comparator or streptozotocin-induced hypoglycemia would be an ideal model for using glibenclamide as positive control. [5]Mortality of rats: Exact number of rats along with cause of death should be mentioned. Whether the insulin plant leaves caused death due to toxicity or hypoglycemia or whether steroids lead to immunosuppression and infection and caused mortality cannot be deciphered.…”

mentioning

confidence: 99%

“…Metformin/Pioglitazone would have been an ideal comparator or streptozotocin-induced hypoglycemia would be an ideal model for using glibenclamide as positive control. [5]…”

mentioning

confidence: 99%

Effect of insulin plant leaves on dexamethasone-induced hyperglycemia

Ghaisas¹

2011

Int J Ayurveda Res

View full text Add to dashboard Cite

Effects of troglitazone on dexamethasone-induced insulin resistance in rats

Cited by 21 publications

References 25 publications

Thiazolidinediones Exert Difterent Effects on Insulin Resistance between Dexamethasone-Treated Rats and Wistar Fatty Rats.

Thiazolidinediones Exert Difterent Effects on Insulin Resistance between Dexamethasone-Treated Rats and Wistar Fatty Rats.

Thiazolidinediones attenuate lipolysis and ameliorate dexamethasone-induced insulin resistance

Effect of insulin plant leaves on dexamethasone-induced hyperglycemia

Contact Info

Product

Resources

About