Effects of triiodothyronine on the normal and regenerating facial nerve of the rat

Stelmack, B. M.; Kiernan, J. A.

doi:10.1007/bf00688704

Cited by 27 publications

(9 citation statements)

References 16 publications

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“…Experimental Heinicke, 1977) or to more rapid reinnervation of motor end-plates (McIsaac & Kiernan, 1975b). In some experiments it has not been possible to demonstrate accelerated axonal regeneration in T,-treated animals Stelmack & Kiernan, 1977). Treatment with T, also results in the formation of thicker myelin sheaths around both normal and regenerated axons (Stelmack & Kiernan, 1977).…”

Section: (A) Thyroid Hormonesmentioning

confidence: 99%

“…In some experiments it has not been possible to demonstrate accelerated axonal regeneration in T,-treated animals Stelmack & Kiernan, 1977). Treatment with T, also results in the formation of thicker myelin sheaths around both normal and regenerated axons (Stelmack & Kiernan, 1977). This effect is probably due to stimulation by the hormone of the metabolic activity of Schwann cells (Valcana et al, 1975).…”

Section: (A) Thyroid Hormonesmentioning

confidence: 99%

“…Kinins produce vasodilatation and increased permeability of capillaries and venules to proteins and cells. They are important as chemical mediators of inflammation (Rocha E Silva, 1970; Wilhelm, 1973) and may also be involved in lesser degrees of vasodilatation and oedema following quite trivial injuries (Chapman, Ramos, Goodell & Wolff, 1961; Kiernan, 1976Kiernan, , 1977. If the kinin-forming action of trypsin manifests itself in the injured C.N.S., the enzyme would cause exudation of plasma proteins around the tips of the regenerating nerve fibres.…”

Section: I79 (B) Reconciliation Of the Hypothesis With Experimental Omentioning

confidence: 99%

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Hypotheses Concerned With Axonal Regeneration in the Mammalian Nervous System

Kiernan

1979

Biological Reviews

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257

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Section: (A) Thyroid Hormonesmentioning

confidence: 99%

Section: (A) Thyroid Hormonesmentioning

confidence: 99%

Section: I79 (B) Reconciliation Of the Hypothesis With Experimental Omentioning

confidence: 99%

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Hypotheses Concerned With Axonal Regeneration in the Mammalian Nervous System

Kiernan

1979

Biological Reviews

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257

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“…These authors suggest that thyroid hormones may control Schwann cell proliferation. Unfortunately, only a few works deal with in vivo Schwann cell proliferation (Asbury, 1967;Salzer & Bunge, 1980a) during normal development, and the effects of thyroid hormones on Schwann cell proliferation were only studied in the case of experimental peripheral nerve regeneration (Stelmack & Kiernan, 1977).…”

Section: Introductionmentioning

confidence: 99%

Schwann cell proliferation in the sciatic nerve of hypothyroid chick embryos studied by autoradiography and image analysis

Usson

Saxod

1988

J Neurocytol

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SummaryThe proliferation of Schwann cells in the sciatic nerve of chick was studied from day 11 to day 27 of development in control and thyroid-deficient embryos. Hypothyroidism was induced by tetramethylthiourea injection on days 8 and 19 of incubation. The parameters of the cell cycle were determined using autoradiographs (tritiated thymidine) and by image analysis of Feulgen-stained nuclear smears. The duration of the cell cycle was lengthened and the growth fraction was reduced in hypothyroid animals, at 11 and 15 days of incubation. At later stages (days 21 and 27), these parameters were not significantly different from the controls as if the sensitivity of Schwann cells to thyroid hormones was scheduled to occur during a limited period of development. The total number of axons was the same in control and hypothyroid animals suggesting that the slowing down of Schwann cell proliferation is not a consequence of neuronal cell death. The consequence of that slowing down is a delay in the isolation of promyelin axons and a reduction in the proportion of myelinated axons at all the stages studied.

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“…Dentre os fármacos mais conhecidos podemos citar: poliaminas e aminoguanidinas (Kaupilla et al, 1988;Gilad et al, 1996), ativadores da adenil-ciclase (Klein et al, 1989;Urbina et al, 1996;Walikonis et al, 1998), fator de crescimento neural (Levi-Montalcini et al, 1953;Levi-Montalcini,1982;Lipton, 1989;Snider et al, 1989;Chen et al, 1989;Santos et al, 1991;Jubran et al, 2003), triancinolonas (Lipton et al, 1986;Bansberg et al, 1987) , alfa-MSH (Edwards et al, 1986), ACTH (Strand et al, 1980), leupeptina (Hurst et al, 1984;Badalamente et al, 1987;Badalamente et al, 1989;), apoliproteínas (Badalamente et al, 1987), T3 (Stelmack et al, 1977), T4 (Danielsen et al, 1986), testosterona (Kujawa et al, 1989, gangliosídeos (Sparrow et al. 1982;Leeden, 1984;Mengs et al, 1987;Cuello et al, 1989;Laineti et al, 1993) e imunossupressores (Gold, 1997;Costa e al., 2006 (Ferreira et al, 1974;Ehrart et al, 1975;Ferreira et al, 1975;Zumiotti et al, 1988;Mattar et al, 1990;Costa, 1998;Costa, 2001 (Ferreira et al, 1985), de paralisias dos membros superiores e inferiores (Ferreira et al, 1974;…”

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Reconstrução de defeito de nervo fibular em ratos com veia glicerolada: análise histológica e funcional

Cunha¹

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pela amizade desde meus dias de faculdade, residência e pós-graduação. Aos meus irmãos, Regina e Sílvio, pelo apoio, amor, amizade e convívio durante toda a minha vida. A João Fábio e Brigite, pelo carinho e por estarem sempre presentes em minha vida no convívio familiar. À minha sogra D. Otacília Vidal, pelo exemplo de humildade e perseverança. A Agner, Jéfferson, Luciana, Roberta, Rodolfo e Marlon, pelo convívio, auxílio, amizade e bons momentos de confraternização. À Marília e Rômulo Terra, pela amizade e apoio em todas situações. À Daniela Renata Crippa pela amizade e convívio nestes últimos anos. Ao Prof. Ciro Ferreira Da-Silva, pelo ensino e incentivo e determinação desde o terceiro ano da faculdade. Por ser um exemplo de pesquisador e professor, tornando-se participante e pessoa fundamental para a realização desta pesquisa. Ao meu colega e amigo Dr. Roberto Albuquerque Ribeiro, que aprendi a admirar e confiar. Agradeço seus conselhos, apoio e incentivo. Ao Dr. Paulo Tuma Jr., pelo exemplo de ética profissional, pelo convívio e conselhos em minha formação de cirurgião plástico. Ao Dr. José Carlos Marques de Faria, que sempre tive como exemplo de cirurgião plástico. Ao Dr. Edgard Cardenas pelo convívio dos últimos anos e sua amizade. Ao Dr. Amir Salomão Gebrin, pela amizade e convívio. Pelas pesquisas realizadas anteriormente que foram base de nosso conhecimento. Aos assistentes da Disciplina de Cirurgia Plástica da Faculdade de Medicina da Universidade de São Paulo, pelos momentos compartilhados e pelos ensinamentos, importantes na minha formação de cirurgião plástico. À Eliane Gazetto da Pós-Graduação da Clínica Cirúrgica pelo auxílio durante o período da pós-graduação. Ao Sr. Fábio Tadeu Montesano, pela realização da estatística deste trabalho através da empresa Domus Numeri. Ao Sr. Márcio Xavier Nascimento, pelas figuras e desenhos deste trabalho através da empresa 3 em 1 Design. À Sra. Fernanda Rizzo Sanchez, pela revisão desta tese. EPÍGRAFE o homem que adquire ente (Provérbios 3:13) Esta tese está de acordo com as seguintes normas, em vigor no momento desta publicação: Referências: adaptado de International Committee

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Effects of triiodothyronine on the normal and regenerating facial nerve of the rat

Cited by 27 publications

References 16 publications

Hypotheses Concerned With Axonal Regeneration in the Mammalian Nervous System

Hypotheses Concerned With Axonal Regeneration in the Mammalian Nervous System

Schwann cell proliferation in the sciatic nerve of hypothyroid chick embryos studied by autoradiography and image analysis

Reconstrução de defeito de nervo fibular em ratos com veia glicerolada: análise histológica e funcional

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