Abstract:Atherosclerosis, a chronic inflammatory arterial disease featured by focal accumulation of fat‐laden deposits, is exacerbated by prolonged circulation of elevated levels of triglyceride‐rich lipoproteins (TGRL). This study aims to examine the effects of TGRL on the inflammatory potential of endothelial cells and the mechanisms for enhanced recruitment of mononuclear cells using vascular mimetics. We have developed an ex vivo atherogenesis model, in which human aortic endothelial cells (HAEC) in culture are per… Show more
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