Effects of triethyltin on brain octopamines and their metabolism in the rat

Coulon, J.F.; Lacroix, Pierre; Linée, P; David, Jean‐Claude

doi:10.1016/0014-2999(87)90756-4

Cited by 3 publications

(1 citation statement)

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“…Of lesser extent, the decreased levels of p-TA in the aging hypothalamus are consistent with the involvement of the decarboxylation step. Although the de-OA, CATECHOLAMINE, AND ENZYME LEVELS rN AGING RAT BRAIN 1.53 crease in AADC activity does not appear to be drastic at 26 months when compared to the decrease of p-OA content, it should be noted that such a decrease in decarboxylation related to p-OA, and not apparently to catecholamine, has been found recently in studies on the effects of triethyltin in rats (Coulon et al, 1987). A possible area for further investigation involves mammalian AADC, which has several subunits (Maneckjee and Baylin, 1983), and these subunits can present differential sensitivities to aging.…”

Section: Discussionmentioning

confidence: 65%

Effects of Aging on p‐ and m‐Octopamine, Catecholamines, and Their Metabolizing Enzymes in the Rat

David

Coulon

Cavoy

et al. 1989

Journal of Neurochemistry

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Functions of octopamine in the mammalian brain are still not well known. An important aspect of this problem is the relationship between octopamines and catecholamines. Previous data have shown that their respective ontogenic evolutions are not parallel. Do the changes in brain related to aging also differentially affect these two groups of molecules? In order to check this point, the brain levels of p- and m-octopamine, p-tyramine, noradrenaline, and dopamine, as well as the activities of metabolizing enzymes, were determined in young adult and aging rats (20-26 months). Unlike catecholamines, there is a drastic decrease of p-octopamine after 20 months of age in the hypothalamus and telencephalon. p-Tyramine levels are also lowered. This change appears to be due to a decrease of the aromatic L-amino acid decarboxylase activity. These data, as those of ontogenic studies, confirm that p-octopamine and catecholamine metabolisms may have some independent steps and, moreover, that p-octopamine may have a role in the normal activity of the brain.

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Section: Discussionmentioning

confidence: 65%