Effects of triclosan on the RedoximiRs/Sirtuin/Nrf2/ARE signaling pathway in mosquitofish (Gambusia affinis)

Bao, Shuang; He, Chuanchao; Ku, Peijia; Xie, Ming; Lin, Jia‐Wei; Lü, Songhui; Nie, Xiaoqin

doi:10.1016/j.aquatox.2020.105679

Cited by 17 publications

(5 citation statements)

References 69 publications

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“…There was a substantial decrease in CAT activity between the treatment and control groups (p < 0.05). The reduction of CAT activity in the liver varies considerably between treatment groups at p < 0.05, with the effect of suppression being most noticeable at the lowest dose (50 g/L) 71 . The apparent decrease in CAT behaviour implies that the produced H 2 O 2 may not be quickly destroyed by CAT, indicating a redox imbalance in the cell.…”

Section: Catalase (Cat)mentioning

confidence: 94%

Triclosan Induced Oxidative Stress, Estrogenicity, Mutagenicity, Carcinogenicity, and Genotoxicity: A Novel Therapeutic Approach

et al. 2021

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Triclosan (TCS) is present in toothpaste and other cosmetic products as an antibacterial and antifungal agent. This manuscript highlights that TCS is a potential oxidative stress-causing agent, an estrogenic, mutagenic, cancer-causing agent, and genotoxic agent present in cosmetic products. This study also summarizes the therapeutic approach to overcome all of the harmful effects. It is a popular current topic, and a new research study is needed to find a new alternative as an antibacterial and anti-fungal agent instead of TCS. TCS causes oxidative stress when the dynamic balance in synthesizing and removing reactive oxygen species (ROS) within typical physiological circumstances is disturbed. The antioxidant defence system includes both enzymatic and non-enzymatic antioxidants produced by the organism to tackle the harmful effects of ROS. TCSs have estrogenic, proliferative, and apoptotic properties due to research on cell fate. The mutagenic potential of TCS has been examined using in vitro and in vivo research in prokaryotic, eukaryotic systems, and mammalian cells. It also induces carcinogenic, estrogenic, and mutagenic effects. TCS's therapeutic effects, especially against inflammatory skin conditions, have been demonstrated by many materials gathered from in vitro and in vivo experiments. The new findings suggest that TCS, a commonly used cosmetic product, may cause cancer, as shown by animal and human models and clinical trials. TCS is not effectively regulated, as evidenced by its presence in various environmental media, human bodies, and animals. Its irresponsible usage and disposal may endanger humans and wildlife. TCS has been found to damage a wide variety of cells in cell-based investigations. TCS's exact function in the environmental selection of antibiotic and multidrug resistance genes is still unclear. Comprehensive evaluations of these domains, especially to derive serious human health risk inferences from TCS outcomes, may help future research and legislation to better serve the public's health.

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Section: Catalase (Cat)mentioning

confidence: 94%

Triclosan Induced Oxidative Stress, Estrogenicity, Mutagenicity, Carcinogenicity, and Genotoxicity: A Novel Therapeutic Approach

et al. 2021

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“…Yoon et al (2017) showed that TCS induces oxidative stress and intracellular accumulation of toxins, at least in part, by disrupting the SKN-1/Nrf2-mediated oxidative stress response, specifically by inhibiting the nuclear localization of SKN-1/Nrf2 and the expression of its target genes, in both a model organism, the nematode Caenorhabditis elegans and human mesenchymal stem cells (hMSCs) [ 233 ]. A recent study on mosquitofish ( Gambusia affinis ) that were exposed to TCS showed that the up-regulations Sirt1 and Sirt2 in Sirtuin family could activate the Nrf2/ARE signaling pathway and the down-regulations of miR-34b and the up-regulations of miR-34a , miR-144, and miR153a-5p modulated the Nrf2/ARE signaling pathway [ 234 ]. Sublethal concentrations of TCS enhanced glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and glutathione-S-transferase enzyme activity in all the tissues with an increased dose and exposure period in the gill, liver, and muscle of an Indian major carp Catla catla [ 235 ].…”

Section: Mechanism Of Action In Pharmacological and Toxicity Studiesmentioning

confidence: 99%

Triclosan: A Small Molecule with Controversial Roles

et al. 2022

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Triclosan (TCS), a broad-spectrum antimicrobial agent, has been widely used in personal care products, medical products, plastic cutting boards, and food storage containers. Colgate Total® toothpaste, containing 10 mM TCS, is effective in controlling biofilm formation and maintaining gingival health. Given its broad usage, TCS is present ubiquitously in the environment. Given its strong lipophilicity and accumulation ability in organisms, it is potentially harmful to biohealth. Several reports suggest the toxicity of this compound, which is inserted in the class of endocrine disrupting chemicals (EDCs). In September 2016, TCS was banned by the U.S. Food and Drug Administration (FDA) and the European Union in soap products. Despite these problems, its application in personal care products within certain limits is still allowed. Today, it is still unclear whether TCS is truly toxic to mammals and the adverse effects of continuous, long-term, and low concentration exposure remain unknown. Indeed, some recent reports suggest the use of TCS as a repositioned drug for cancer treatment and cutaneous leishmaniasis. In this scenario it is necessary to investigate the advantages and disadvantages of TCS, to understand whether its use is advisable or not. This review intends to highlight the pros and cons that are associated with the use of TCS in humans.

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“…On contrary, long-term triclosan exposure has been shown to induce liver weight with concomitant accumulation of a large number of lipid droplets, thereby caused deleterious effects on liver growth and development in zebrafish (Liu et al, 2019). Triclosan exposure caused tissue-specific hepatotoxicity in the adult mosquitofish, Gambusia affinis by interrupting many biological pathways associated with lipogenesis and lipid metabolism, transmembrane transporters, protein synthesis and carbohydrate metabolism (Song et al, 2021), and these transcriptional responses are mediated through RedoximiRs/Sirtuin/Nrf2/ARE signalling pathway (Bao, He, et al, 2021). The variation in the age, size, species, concentration of the toxicant, duration of exposure and so on, could be the reasons for the variation in the organ toxicity.…”

Section: Alteration Of Bodyweight Mucous Deposition and Liver Tissue Weightsmentioning

confidence: 99%

Triclosan at environmental concentration alters the hepatic antioxidant defence system in the fish, Anabas testudineus (Bloch, 1792)

et al. 2021

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Triclosan, a chlorinated, non-polar aromatic compound, is commercially used worldwide in different trade names such as Cloxifenolum, Irgasan ® PG60; Irgasan ® DP 300; Kopsan; Lexol 300 and Ster-Zac (Regos et al., 1979;Weatherly & Gosse, 2017). The antimicrobial property of triclosan added its applications into a variety of consumer products including soaps, hand sanitizers, toothpaste, mouthwash, cosmetics, detergents, toys, pharmaceuticals, deodorants, etc (Andersen et al., 2015). The widespread usage in many commercial products increased its production rate to 3,200 tonnes per annum in Asia, and 100 to 1000 tonnes in European countries with the highest triclosan consumption in Europe than the other parts of the world (FDA, 2013). The Food and Drug Administration in 2016 banned the use of triclosan as active ingredients in antibacterial soaps; however, it forms a major component in other consumer

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Effects of triclosan on the RedoximiRs/Sirtuin/Nrf2/ARE signaling pathway in mosquitofish (Gambusia affinis)

Cited by 17 publications

References 69 publications

Triclosan Induced Oxidative Stress, Estrogenicity, Mutagenicity, Carcinogenicity, and Genotoxicity: A Novel Therapeutic Approach

Triclosan Induced Oxidative Stress, Estrogenicity, Mutagenicity, Carcinogenicity, and Genotoxicity: A Novel Therapeutic Approach

Triclosan: A Small Molecule with Controversial Roles

Triclosan at environmental concentration alters the hepatic antioxidant defence system in the fish, Anabas testudineus (Bloch, 1792)

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