Effects of triclocarban on oxidative stress and innate immune response in zebrafish embryos

Wei, Jiajing; Zhou, Ting; Hu, Zhiyong; Li, Ying; Yuan, Hongfang; Zhao, Kai; Zhang, Huiping; Liu, Chunyan

doi:10.1016/j.chemosphere.2018.06.163

Cited by 68 publications

(15 citation statements)

References 35 publications

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“…In the early developmental stages of zebrafish, the innate immune system is the only defense system against infections caused by toxic agents 45 . Previous studies have been reported that some pathogens, pesticides and other environmental pollutants could induce or inhibit the mRNA expression of genes related to the innate immune system and stimulate pro‐inflammatory cytokine production in cells of zebrafish 44,46,47 . In the present study, it was observed that the expression of il‐1β and il‐8 was up‐regulated by nanopesticide exposure.…”

Section: Discussionsupporting

confidence: 52%

“…45 Previous studies have been reported that some pathogens, pesticides and other environmental pollutants could induce or inhibit the mRNA expression of genes related to the innate immune system and stimulate pro-inflammatory cytokine production in cells of zebrafish. 44,46,47 In the present study, it was observed that the expression of il-1β and il-8 was up-regulated by nanopesticide exposure. These results indicated that CNPE might disturb innateimmune system functions in zebrafish embryos/larvae.…”

Section: Gene Expressionsupporting

confidence: 51%

“…Among cytokines, il‐1β and il‐8 are used as markers of an active inflammatory response. These cytokines play a key role in the aggregation of phagocytes and activating of neutrophil and other granulocytes at the infection site 44 . In the early developmental stages of zebrafish, the innate immune system is the only defense system against infections caused by toxic agents 45 .…”

Section: Discussionmentioning

confidence: 99%

“…37 The exposure to Ag, ZnO, and CuO NPs also reduced hatching success. [37][38][39] On the other hand, 44 In the early developmental stages of zebrafish, the innate immune system is the only defense system against infections caused by toxic agents. 45 Previous studies have been reported that some pathogens, pesticides and other environmental pollutants could induce or inhibit the mRNA expression of genes related to the innate immune system and stimulate pro-inflammatory cytokine production in cells of zebrafish.…”

Section: Gene Expressionmentioning

confidence: 99%

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Developmental toxicity induced by Cu(OH)₂ nanopesticide in zebrafish embryos

Aksakal

Şi̇şman

2020

Environmental Toxicology

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The current study evaluates the adverse effects of Cu(OH)2 nanopesticide (CNPE) on the early life stages of zebrafish (Danio rerio). The developmental toxicity was determined using different parameters such as mortality (including LC50), hatching, heart rates, malformations, and alteration of the gene expressions. Zebrafish embryos (4 hpf‐hours postfertilization) were exposed to 1.0, 2.0, 4.0, 8.0, and 16.0 mg/l CNPE doses until 96 hpf. The 96 hours LC50 was recorded at 6.258 mg/l. Seventy‐two hpf total malformation index values for 2.0, 4.0, and 8.0 mg/l CNPE doses were 4.3, 7.2 and 7.9, respectively. 1.0 mg/l CNPE is not toxic for the zebrafish embryos/larvae. 2.0 to 8.0 CNPE doses caused some abnormalities in embryos/larvae morphology, including lack of body parts, tail deformities, chorda deformity, bubbled head, scoliosis, lordosis, weak or non‐pigmentation, decreased heart rate and larva length. 16.0 mg/l CNPE caused mortality in 72 hpf. The expression levels of seven immune system‐related genes (il‐1β, il‐8, cebp, tlr4, hsp70, NF‐kB, and mtf‐1) were examined. The transcription level of il‐1β, il‐8, tlr4, hsp70, and NF‐kB genes significantly increased in the CNPE exposure groups. While the expression of the mtf‐1 gene considerably decreased, the cebp gene expression level did not change in the 4.0 and 8.0 mg/l CNPE doses. In conclusion, CNPE could induce developmental toxicity with malformations in embryos/larvae and alter the gene expression.

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Section: Discussionsupporting

confidence: 52%

Section: Gene Expressionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Gene Expressionmentioning

confidence: 99%

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Developmental toxicity induced by Cu(OH)₂ nanopesticide in zebrafish embryos

Aksakal

Şi̇şman

2020

Environmental Toxicology

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“…The result shows it improved expression levels of oxidative stress-related genes in the fish liver [33]. Zebrafish embryo exposure to Triclocarban (TCC) at environmental concentrations significantly affects the expression of immune-response-related genes following oxidative stress and the release of proinflammatory mediators through the Toll-like receptor signaling pathway [34]. Thirteen TLRs have been discovered in mammals to date [35].…”

Section: Tlrs and Their Signaling Pathwaymentioning

confidence: 99%

Roles of Toll-Like Receptors in Nitroxidative Stress in Mammals

Deng

Lian

et al. 2019

Cells

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Free radicals are important antimicrobial effectors that cause damage to DNA, membrane lipids, and proteins. Professional phagocytes produce reactive oxygen species (ROS) and reactive nitrogen species (RNS) that contribute towards the destruction of pathogens. Toll-like receptors (TLRs) play a fundamental role in the innate immune response and respond to conserved microbial products and endogenous molecules resulting from cellular damage to elicit an effective defense against invading pathogens, tissue injury, or cancer. In recent years, several studies have focused on how the TLR-mediated activation of innate immune cells leads to the production of pro-inflammatory factors upon pathogen invasion. Here, we review recent findings that indicate that TLRs trigger a signaling cascade that induces the production of reactive oxygen and nitrogen species.

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Isoliquiritigenin induces oxidative stress and immune response in zebrafish embryos

Fang

Zhong

et al. 2023

Environmental Toxicology

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Isoliquiritigenin (ISL) is used in many households' personal hygiene and medicinal products, and the average human daily ISL exposure is 1-2 mg/kg. However, the molecular mechanisms of ISL toxicity in zebrafish embryos have not been fully elucidated. We investigated whether exposure to ISL induces oxidative stress and inflammatory responses in zebrafish. And exposure to ISL significantly affects the expression of immune response-related genes in zebrafish embryos following oxidative stress and the release of pro-inflammatory mediators through Toll-like receptor signaling.

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Effects of triclocarban on oxidative stress and innate immune response in zebrafish embryos

Cited by 68 publications

References 35 publications

Developmental toxicity induced by Cu(OH)₂ nanopesticide in zebrafish embryos

Developmental toxicity induced by Cu(OH)₂ nanopesticide in zebrafish embryos

Roles of Toll-Like Receptors in Nitroxidative Stress in Mammals

Isoliquiritigenin induces oxidative stress and immune response in zebrafish embryos

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Effects of triclocarban on oxidative stress and innate immune response in zebrafish embryos

Cited by 68 publications

References 35 publications

Developmental toxicity induced by Cu(OH)2 nanopesticide in zebrafish embryos

Developmental toxicity induced by Cu(OH)2 nanopesticide in zebrafish embryos

Roles of Toll-Like Receptors in Nitroxidative Stress in Mammals

Isoliquiritigenin induces oxidative stress and immune response in zebrafish embryos

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Product

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Developmental toxicity induced by Cu(OH)₂ nanopesticide in zebrafish embryos

Developmental toxicity induced by Cu(OH)₂ nanopesticide in zebrafish embryos