Effects of treatment with somatostatin analogues on QT interval duration in acromegalic patients

Fatti, Letizia Maria; Scacchi, Massimo; Lavezzi, Elisabetta; Giraldi, Francesca Pecori; Martin, Martina De; Toja, Paola; Michailidis, Georgios; Stramba-Badiale, Marco; Cavagnini, Francesco

doi:10.1111/j.1365-2265.2006.02639.x

Cited by 62 publications

(62 citation statements)

References 24 publications

(54 reference statements)

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“…In literature, the number of studies showing lengthened QT intervals in patients with acromegaly is uncommon. [16][17][18][19] As consistent with previous ones, it was demostrated in our study that baseline QT max, QT dispersion, QTc max and QTc dispersion were longer, compared to controls. Lengthening of QT intervals in patients with acromegaly can be explained by the direct effects of GH and IGF-1 on myocardium or left ventricular hypertrophy due to DM, HT and similar disorders.…”

Section: Discussionsupporting

confidence: 91%

“…20 Fatti et al also detected no correlation between GH and IGF-1 levels, and pre-and post-treatment QTc intervals. 17 As consistent with Fatti et al, Unubol et al observed no correlation between GH and IGF-1, and QTc dispersion. 18 In our study, a correlation was detected only between GH and post-treatment QTc dispersion.…”

Section: Discussionsupporting

confidence: 73%

“…17 Pathological ECGs even in patients with remission might point out irreversible fibrotic process and permanent arrhythmogenic pathways. 20 In a study by Maffei et al, late QT max: QT maximum, QT min: QT minimum, QTc: corrected QT potentials were reported not to be related with GH and IGF-1 levels, and they supposed that GH and IGF-1 play no role in arrhytmic process.…”

Section: Discussionmentioning

confidence: 99%

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The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients

Başer¹,

Bayram²,

Polat³

et al. 2014

Acta Med Port

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Introduction: It was aimed to calculate QT intervals in patients with acromegaly and to reveal its correlation between QT intervals, and growth hormone and insulin like growth factor-1. Material and Methods: Forty-one patients with acromegaly were enrolled into the study. Another 41 individuals with similar features, such as comorbid diseases, age and sex constituted the control group. The electrocardiographies of patients with acromegaly were evaluated at the baseline and after the follow-up. Only one electrocardiography was performed for controls. QT maximum, QT minimum, QT dispersion, corrected QT maximum, corrected QT minimum and corrected QT dispersion were calculated. Results: Baseline QT maximum, QT dispersion, corrected QT maximum and corrected QT dispersion were significantly longer than the values of controls. Corrected QT maximum and corrected QT dispersion were significantly shorter after the follow-up, compared to the baseline in patients. QT maximum, QT dispersion, corrected QT maximum and corrected QT dispersion after the follow-up were not statistically different from the values of controls. Except the negative correlation between growth hormone and corrected QT dispersion in patients after the follow-up, no other correlation was detected between QT values and growth hormone or insulin like growth factor-1 levels. Corrected QT dispersion was found to be related with the disease duration in patients. Discussion: For acromegaly patients, it is important to detect clinical predictors of cardiac arrhytmias. QT dispersion is considered a beneficial predictor for ventricular arrhytmias. When compared to controls, prolonged QT intervals were determined in our acromegalic patients. Conclusion:We consider that QT intervals may also be utilized in the evaluation of increased cardiovascular risk in patients with acromegaly. Keywords: Acromegaly; Arrhythmias, Cardiac; Electrocardiography; Heart Rate. RESUMO

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients

Başer¹,

Bayram²,

Polat³

et al. 2014

Acta Med Port

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“…Electrocardiographic QT complex (QTc) interval (which is significantly longer in patients with active acromegaly and can contribute to fatal arrhythmias) was significantly shortened and normalized after 3-63 months octreotide LAR or lanreotide SR treatment, along with reduction of heart rate. Six patients with acromegaly had pathologically prolonged QTc which normalized after treatment (Fatti et al, 2006).…”

Section: Symptom Controlmentioning

confidence: 99%

Somatostatin agonists for treatment of acromegaly

Ben-Shlomo

Melmed

2008

Molecular and Cellular Endocrinology

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The discovery of somatotropin-release inhibitory factor (SRIF) in hypothalamic extract in 1970 led to the synthesis of the first somatostatin analog octreotide, discovery of five somatostatin receptor subtypes, and development of additional somatostatin receptor ligands (SRL) as pharmacotherapy for acromegaly and other neuroendocrine tumors. Long-acting formulations of SRL (octreotide LAR Depot, lanreotide SR and lanreotide autogel) assure improved patient compliance with weekly up to monthly injections, and are commonly used as primary or adjuvant treatment of acromegaly. We review SRL currently available, emphasizing long-acting compounds and their efficacy in controlling acromegaly. Disease control is evaluated by biochemical markers, tumor shrinkage, and diseasesymptom improvement balanced against drug-related side effects.

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“…Fatti et al [Fatti et al 2006] detected abnormally long QTc interval before treatment in one-quarter of 30 acromegalic patients in a retrospective study.…”

Section: Short-term Variability Of Qt Interval In Patients With Acrommentioning

confidence: 99%

Analysis of short-term temporal variability of cardiac ventricular repolarization in subjects with different clinical conditions

Orosz

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Effects of treatment with somatostatin analogues on QT interval duration in acromegalic patients

Cited by 62 publications

References 24 publications

The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients

The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients

Somatostatin agonists for treatment of acromegaly

Analysis of short-term temporal variability of cardiac ventricular repolarization in subjects with different clinical conditions

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