Effects of treatment with coenzyme Q₁₀on exercised rat aorta

Abstract

In this study, the effect of long-term supplementation of coenzyme Q10 (CoQ10) on the responses of swim-trained rat aorta was investigated. Twenty-four adult male Wistar rats were divided into four groups: untrained, trained, untrained+CoQ10, and trained+CoQ10 group. In the trained groups rats swam for 60 min/day, five days/week for six weeks. The CoQ10 supplements were administered by intraperitoneal injection at a daily dose of 10 mg·kg-1 of body weight five days/week for six weeks. Swimming of the rats was performed in a container containing tap water. Rats were sacrificed and thoracic aortas were removed for ex vivo analysis after the last swimming session. The aortas were cut into rings 2.5 mm in length. Concentration-response curves for phenylephrine (PHE, 10-9-3×10-4 M) and potassium chloride (KCl, 5-100 mM) were isometrically recorded. The sensitivity and maximal responses to PHE and KCl of aortic rings obtained from trained rats were lower than those of untrained rats. CoQ10 supplementation decreased the responses to both vasoconstrictors in untrained and especially in trained groups. Although neither CoQ10 nor training did affect malondialdehyde (MDA) and protein carbonyl (PC) levels, creatine kinase (CK) activity decreased and superoxide dismutase (SOD) activity increased only with exercise training. Glutathione (GSH) levels increased in CoQ10 supplemented-untrained rats. In conclusion, our results suggest that CoQ10 supplementation may have beneficial effects during exercise.

Aortic Response to Strength Training and Spirulina platensis Dependent on Nitric Oxide and Antioxidants

“…The improvement in vascular reactivity, represented by the reduction in the contractile activity (Delbin et al, 2012 ; Okudan et al, 2012 ) and increased relaxing activity (Valgas Da Silva et al, 2014 ) is already well established for the aerobic exercise modality. Concerning the role of strength training in vascular reactivity, three studies have demonstrated improvement in relaxing activity (Figard et al, 2006 ; Harris et al, 2010 ; Araujo et al, 2013 ) and only in one of them the contractile reactivity with a reduction in this activity was measured (Araujo et al, 2013 ).…”

Coenzyme Q10 Supplementation and Regular Physical Exercise Affect the Level of Glutathione and Superoxide Dismutase in the Brain

“…CoQ 10 takviyesinin, düzenli egzersiz uygulamasının ve akut egzersizlerin oksidatif stres üzerine etkilerini farklı dokularda inceleyen araştırmalara rağmen beyin dokusundaki etkileriyle ilgili çalışma-lar sınırlıdır (18)(19)(20)(21). Bu çalışmada, sıçan beyin dokusunda tüken-me egzersiziyle oluşan oksidatif hasar ve antioksidan enzim düzey-leri üzerine yüzme antrenmanlarının ve CoQ 10 takviyesinin etkileri araştırılmıştır.…”