Effects of treatment with and without adjuvant radiation therapy on recurrence of ocular and adnexal squamous cell carcinoma in horses: 157 cases (1985–2002)

Abstract

Results indicated that ocular and adnexal SCCs treated with adjuvant radiation therapy had a significantly lower recurrence rate, compared with SCCs treated without adjuvant radiation therapy, independent of anatomic location.

Equine ocular squamous cell carcinoma: a case report

“…In horses , CSCC constitutes from 19.1% (Mosunic et al 2004) to approximately 21% of all OSCCs (Dugan et al 1991b). There are a number of OSCC treatment options.…”

“…The disease mainly affects horses eight to 13 years old (Gelatt et al 1974;Schwink 1987;Mosunic et al 2004;Michau et al 2012;Lassaline et al 2014). A more frequent incidence of the neoplasm has been reported in equine breeds with a grey hair coat component than in dark-pigmented horses (Gelatt et al 1974;Lavach and Severin 1977;Dugan et al 1991a).…”

“…To date, the pathogenesis of OSCC has not been fully elucidated (Dugan et al 1991a;Sironi et al 1999;Mosunic et al 2004;Lassaline et al 2014). It is thought that prolonged sunlight exposure plays a significant role in the occurrence of SCCs (Dugan et al 1991a).…”

“…The recurrence rate ranges from 11.1% to 66.7% and is associated with factors such as the type of applied treatment (King et al 1991;Mosunic et al 2004;Michau et al 2012). In addition, recurrences are more common in OSCC affecting the eyelids than in the corneal form of the tumour (Dugan et al 1991b;King et al 1991).…”

“…Changes in oestrogen and androgen levels in the blood are additional elements of SCC aetiology in horses (Lavach and Severin 1977;Dugan et al 1991a;Mosunic et al 2004). The disease mainly affects horses eight to 13 years old (Gelatt et al 1974;Schwink 1987;Mosunic et al 2004;Michau et al 2012;Lassaline et al 2014).…”