Effects of treatment status and life quality on anxiety in MMT patients

Cao, Penghui; Zhang, Zhaohua; Zhong, Jun; Xu, Shichao; Huang, Qiaofang; Fan, Ni

doi:10.1186/s13011-021-00343-4

Cited by 8 publications

(5 citation statements)

References 33 publications

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“…During the one-year follow-up period, 19 of the 37 patients undergoing MMT (51.35%) relapsed. The number of occurrences of relapse within a year was 5.25 ± 2.83 (range, [1][2][3][4][5][6][7][8][9][10][11]. The number of relapses was negatively related to the total methadone dose in 1 year (r = −0.515, p = 0.001, Bonferroni corrected p = 0.05/5 = 0.01; Figure 3).…”

Section: Relapsementioning

confidence: 96%

“…Relapse rates were even higher with 60% after 1 year ( 7 ). Moreover, MMT increases anxiety symptom among HUDs ( 8 ), which may lead to high suicide rate ( 9 ) and increased relapse rate ( 8 ). For individuals with HUD, the effect of MMT on the functional connectivity of brain is largely unknown, and neuroimaging methods may help characterize the mechanisms underlying the effects of MMT on the brain.…”

Section: Introductionmentioning

confidence: 99%

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Methadone maintenance treatment alters couplings of default mode and salience networks in individuals with heroin use disorder: A longitudinal self-controlled resting-state fMRI study

Chen

Li²,

Wang

et al. 2023

Front. Psychiatry

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BackgroundMethadone maintenance treatment (MMT) is a common treatment for heroin use disorder (HUD). Although individuals with HUD have been reported to show impaired coupling among the salience network (SN), executive control network (ECN), and default mode network (DMN), the effects of MMT on the coupling among three large-scale networks in individuals with HUD remains unclear.MethodsThirty-seven individuals with HUD undergoing MMT and 57 healthy controls were recruited. The longitudinal one-year follow-up study aimed to evaluate the effects of methadone on anxiety, depression, withdrawal symptoms and craving and number of relapse, and brain function (SN, DMN and bilateral ECN) in relation to heroin dependence. The changes in psychological characteristics and the coupling among large-scale networks after 1 year of MMT were analyzed. The associations between the changes in coupling among large-scale networks and psychological characteristics and the methadone dose were also examined.ResultsAfter 1 year of MMT, individuals with HUD showed a reduction in the withdrawal symptom score. The number of relapses was negatively correlated with the methadone dose over 1 year. The functional connectivity between the medial prefrontal cortex (mPFC) and the left middle temporal gyrus (MTG; both key nodes of the DMN) was increased, and the connectivities between the mPFC and the anterior insular and middle frontal gyrus (key nodes of the SN) were also increased. The mPFC-left MTG connectivity was negatively correlated with the withdrawal symptom score.ConclusionLong-term MMT enhanced the connectivity within the DMN which might be related to reduced withdrawal symptoms, and that between the DMN and SN which might be related to increase in salience values of heroin cues in individuals with HUD. Long-term MMT may be a double-edged sword in treatment for HUD.

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Section: Relapsementioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Methadone maintenance treatment alters couplings of default mode and salience networks in individuals with heroin use disorder: A longitudinal self-controlled resting-state fMRI study

Chen

Li²,

Wang

et al. 2023

Front. Psychiatry

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“…The studies that used RAM for nursing care in chronic diseases such as chronic obstructive pulmonary disease and heart failure disease showed positive results of the model, such as increasing adaptation and QOL ( 10 , 14 ). As stated, compliance with and continuing the pharmacological and non-pharmacological treatment of addiction can be one of the important causes of improving the QOL in patients with opioid abuse, as indicated in the study of Cao et al ( 15 ). Moreover, beginning and continuing treatment through nursing intervention and care can lead to the continuation of pharmacological and non-pharmacological treatment, resulting in increased QOL in patients with opioid abuse ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Roy's Adaptation Model on Quality of Life in People with Opioid Abuse under Methadone Maintenance Treatment: A Randomized Trial

Rezazadeh¹,

Hosseini²,

Musarezaie³

2023

Ethiop J Health Sci

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BACKGROUND፡ Opioid abuse is one of the most obvious problems in today's world and directly affects individuals' quality of life. The present study aimed to investigate the effects of Roy's adaptation model on the quality of life in people with opioid abuse under methadone maintenance treatment.METHODS: This randomized trial study was conducted in 2021 on 72 patients with opioid abuse under methadone maintenance treatment at the Center for Addiction Harm Reduction in Isfahan. The samples were randomly allocated into intervention (n=36) and control groups (n=36) based on the table of random numbers by computer. The intervention was conducted by implementing Roy's adaptation model in the intervention group. To analyze the data, paired t-test, independent sample t-test, chi-square test, and analysis of covariance were used.RESULTS: The mean ± standard deviation of the quality of life score in the intervention group (28.96±4.79) was significantly different than before the intervention (24.02±6.09) (P<0.001). At the same time, it was not significantly different in the control group. The mean ± standard deviation of the quality of life score in the intervention group (24.02±6.09) was not significantly different from the control group (20.55±8.53) before the intervention.CONCLUSION: Roy's adaptation model had positive effects on the quality of life score in patients with opioid abuse. On the other hand, patients' quality of life indicates the effectiveness of methadone maintenance treatment. Therefore, it is suggested to use this model in nursing care programs.

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“…In China, heroin was the dominant illicit drug in the late 1990s, resulting in the launch of a series of harm-reduction interventions, including methadone maintenance treatment (MMT) [ 2 ]. The program was rapidly scaled up nationwide over the past two decades, ranked the world’s largest MMT program, covering 30 of 31 provinces and serving approximately 300,000 users [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Benefits and challenges experienced by participants on long-term methadone maintenance treatment in China: a qualitative study

Tang,

Xiong,

Chen

et al. 2024

BMC Med

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Background Methadone maintenance treatment (MMT) has been implemented in China for nearly two decades, with a significant decrease in the number of participants in recent years. However, there is a lack of comprehensive research focusing on the long-term effectiveness in the context of this decline, especially from the perspectives of MMT participants themselves. This study aims to address this gap by examining the benefits and challenges experienced by long-term MMT participants in China, to uncover potential causes of the decrease in participant numbers and to improve the effectiveness of the program. Methods We conducted semi-structured interviews with 21 long-term MMT participants (treatment duration ≥ 5 years) recruited through purposive sampling from 6 MMT clinics in the Guangdong Province, China, between December 2021 and August 2022. Thematic analysis was employed to analyze the transcribed interviews. Two analysts independently coded the data, and a third researcher double-coded 20% of transcripts to ensure intercoder reliability. Results Overall, participants corroborated the notable decline in MMT participants during their long-term MMT, citing death, arrest, and self-perceived abstinence from heroin, as their perceived driving factors. They reported positive changes in their health, family relationships, and social functioning. However, they identified economic hardship as their greatest challenge associated with MMT, further exacerbated by other barriers including the conflict of clinic opening hours and working schedules, discrimination from employers, and COVID-19-related restrictions. Additionally, participants identified issues with dose adjustment and emergency treatment continuation. Conclusions This study outlines the overall improvement in the quality of life of long-term MMT participants. However, it highlights the need for official guidelines for dose adjustment and emergency treatment continuation as well as the provision of health education, job referrals, and flexibility of clinic opening times to facilitate the return to society receiving participants. Establishing a follow-up mechanism for those receiving MMT is also recommended to prevent relapses to heroin and other illicit substances.

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Effects of treatment status and life quality on anxiety in MMT patients

Cited by 8 publications

References 33 publications

Methadone maintenance treatment alters couplings of default mode and salience networks in individuals with heroin use disorder: A longitudinal self-controlled resting-state fMRI study

Methadone maintenance treatment alters couplings of default mode and salience networks in individuals with heroin use disorder: A longitudinal self-controlled resting-state fMRI study

Effects of Roy's Adaptation Model on Quality of Life in People with Opioid Abuse under Methadone Maintenance Treatment: A Randomized Trial

Benefits and challenges experienced by participants on long-term methadone maintenance treatment in China: a qualitative study

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