Effects of treatment on free radicals in patients with pulmonary tuberculosis in South Western Nigeria.

Adebimpe, Wasiu Olalekan; Faremi, Ayodeji; Nassar, Sulaiman Adebayo

doi:10.4314/ahs.v15i4.26

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…Simultaneous application of two drugs with analgesic effect can achieve better analgesic effect. Perioperative hemodynamic changes generate more oxygen radicals, which can damage tissues after oxidation reactions with lipids in tissues, producing MDA [20]. SOD is a very important class of antioxidant enzymes in the body, which can scavenge oxygen radicals by catalytic reduction reactions [21].…”

Section: Discussionmentioning

confidence: 99%

The Value of Combined Application of Oxycodone Hydrochloride Injection and Dexmedetomidine in Anesthesia for LC for Patients with Gallbladder Lesions

Wang¹,

Xu²

2021

Journal of Healthcare Engineering

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Objective. To analyze the effect of combined application of oxycodone hydrochloride injection and dexmedetomidine in anesthesia for laparoscopic cholecystectomy (LC) for patients with gallbladder lesions. Method. 93 patients with gallbladder lesions in our hospital were divided into 2 groups by the random number table method. 46 patients in the control group applied oxycodone hydrochloride injection in anesthesia, and 47 patients in the observation group applied oxycodone hydrochloride injection combined with dexmedetomidine in anesthesia. Result. The T1 and T2 MAP levels in the observation group were lower than those in the control group ( P < 0.05 ), and the difference between T3 and the control group was not significantly significant ( P > 0.05 ). The T1 to T3 HR level in the observation group were lower than those in the control group ( P < 0.05 ). The rate of excessive sedation (10.64%) and sedation inefficiency (12.77%) in the observation group was lower than that in the control group (28.26% and 30.43%), and the rate of satisfactory sedation (76.60%) was higher than that in the control group (41.30%) ( P < 0.05 ). The postoperative awakening, tracheal tube removal, and first anal venting time were shorter in the observation group than in the control group ( P < 0.05 ). The WHO scores of incisional pain at 6, 12, 24, and 48 hours after the operation were lower in the observation group than in the control group ( P < 0.05 ). The T2 SOD level in the observation group was higher than that in the control group, and the ROS and MDA levels were lower than those in the control group ( P < 0.05 ). The incidence of side effects of anesthetic in the observation group was 17.02%, which was not statistically different from the control group of 13.04% ( P > 0.05 ). Conclusion. The combined application of oxycodone hydrochloride injection and dexmedetomidine in anesthesia for LC for patients with gallbladder lesions can achieve better sedation and analgesia effect, accelerate postoperative awakening and recovery, and control oxidative stress and fluctuations in signs, without increasing anesthesia-related side effects.

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Section: Discussionmentioning

confidence: 99%

The Value of Combined Application of Oxycodone Hydrochloride Injection and Dexmedetomidine in Anesthesia for LC for Patients with Gallbladder Lesions

Wang¹,

Xu²

2021

Journal of Healthcare Engineering

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“…The enhanced generation of reactive oxygen species (ROS) generated as a host defensive mechanism against mycobacterium increases tissue injury and inflammation which can lead to immunosupression (7). Using a suitable antioxidant therapy is suggested as a beneficial approach for faster recovery (7,(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

The Role of Medical Ozone in Improving Antioxidant Status in Multiple Drug-Resistant Tuberculosis Patients: A Quasi-experimental Study

Shah¹,

Anande²,

Powar³

et al. 2019

Middle East J Rehabil Health Stud

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Background: Multiple drug-resistant tuberculosis (MDR-TB) is a growing public health threat. Oxidative stress is reckoned as one of the rate-limiting steps in the progression of TB. Oxidative stress increases the level of tissue injury and organ damage. The use of medical ozone therapy is gaining popularity due to its anti-microbial property and its homeostatic potential. Objectives: The present study investigates the role of ozone therapy in boosting the antioxidant status of MDR-TB patients. Methods: Medical Ozone therapy was given through rectal insufflations for 21 days in seven MDR-TB patients (five males and two females) who were under anti-Koch Treatment-4 were enrolled after obtaining written consent. The sessions were spaced out at a rate of three sessions per week. Blood serum and plasma samples were collected from the patients at the baseline and at the end of the 21st session to assess the antioxidant status of superoxide dismutase (SOD) and glutathione reductase (GR) and other biochemical parameters. Results: Statistically significant rise was observed in SOD (P = 0.028), but not in GR (P = 0.058). No other biochemical profiles showed any statistically significant change except for a reduction in serum glutamic-pyruvic transaminase (P = 0.026). Participants also expressed subjective improvement in their mental status. However, we have not used any validated scales to record their mental status. Conclusions:The present study suggests that ozone can be a promising medium in tackling the oxidative stress and enhancing the positive mental attitude in ailing MDR-TB patients. Therefore, it can be considered as adjuvant therapy in treating MDR-TB. However, there are major limitations like smaller sample size and lack of control group. Large scale randomized trials are warranted.

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“…Infectious diseases: The infectious disease section begins with a systematic review of factors associated with tuberculosis recurrence in people living with HIV in Africa 24 . It continues with the prevalence of positive tuberculin skin test and associated factors among Makerere medical students in Uganda 25 and the effects of treatment on free radicals in patients with pulmonary tuberculosis 26 . Now, we move into the realm of ethno-pharmacology.…”

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confidence: 99%

Editorial: From sexual orientation to cochlear transplants in a tropical environment

Tumwine¹

2016

Afr H. Sci.

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Welcome to this December issue of African Health Sciences in which we bring you topical subjects ranging from sexual orientation of University students 1 to HIV, TB and cochlear transplants in a tropical environment. The menu will have something for you and for all of us interested in health and development in Africa and among the diaspora. Reproductive health: South African and Thai researchers introduce us to the reproductive health discourse describing reasons non-use of contraception among university students in 22 countries 2 , while Nigerian authors tackle the issue of sexual orientation among university students in what has emerged as Africa's largest economy 3. Scandinavian researchers have also bravely tackled another emotive subject among women: skin bleaching. 4 Their findings are disturbing but not stunning. What we need are projects to sensitize women and men of colour on the physical, cultural and psychological dangers of skin bleaching.

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Effects of treatment on free radicals in patients with pulmonary tuberculosis in South Western Nigeria.

Cited by 6 publications

References 13 publications

The Value of Combined Application of Oxycodone Hydrochloride Injection and Dexmedetomidine in Anesthesia for LC for Patients with Gallbladder Lesions

The Value of Combined Application of Oxycodone Hydrochloride Injection and Dexmedetomidine in Anesthesia for LC for Patients with Gallbladder Lesions

The Role of Medical Ozone in Improving Antioxidant Status in Multiple Drug-Resistant Tuberculosis Patients: A Quasi-experimental Study

Editorial: From sexual orientation to cochlear transplants in a tropical environment

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