Effects of treatment in hypertension results of a controlled study

Wolff, Frederick W.; Lindeman, Robert D.

doi:10.1016/0021-9681(66)90128-7

Cited by 135 publications

(44 citation statements)

References 11 publications

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“…The two trials with the largest number of events had more patients with an increase in blood urea nitrogen or creatinine during active rather than during placebo therapy. 17 However, in the Wolff and Lindeman trial, more patients in the active-therapy group than in the control group experienced a decline in blood urea nitrogen of greater than 5 mg/dl. Two of the six trials reported proteinuria as an outcome measure and, in both trials, proteinuria was less common during active therapy.…”

Section: -22mentioning

confidence: 98%

Hypertension as a risk factor for renal disease. Review of clinical and epidemiological evidence.

1989

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Section: -22mentioning

confidence: 98%

Hypertension as a risk factor for renal disease. Review of clinical and epidemiological evidence.

1989

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“…Ten trials were identified that met the inclusion criteria 20,27,28,30,[34][35][36][37][38][39] (Table 1). These encompassed a total of 26 521 individuals and 114 000 person-years of observation.…”

Section: Resultsmentioning

confidence: 99%

Does treatment of non-malignant hypertension reduce the incidence of renal dysfunction? A meta-analysis of 10 randomised, controlled trials

Hsu

2001

J Hum Hypertens

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Objective: It remains controversial whether non-malignant 'benign' hypertension causes renal dysfunction. The effect of lowering blood pressure on the incidence of renal dysfunction among patients with non-malignant hypertension is not clear. This meta-analysis was conducted to determine whether antihypertensive drug therapy reduces the incidence of renal dysfunction in patients with non-malignant hypertension. Methods: Randomised, controlled trials of antihypertensive drug therapy of more than 1 year duration that reported renal dysfunction as an outcome were identified through MEDLINE search and literature review. A random effects model was used to obtain summary estimates. Results: Ten trials were identified, involving 26 521 individuals and 114 000 person-years. All excluded subjects with advanced baseline renal disease. Definition of renal

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“…They examined three studies 10,21,22 in marked hypertension (entry diastolic pressure 100-130 mm Hg). Amongst these the principal therapeutic benefit with drug therapy was an 89% reduction in congestive cardiac failure, P Ͻ 0.001.…”

Section: The Gueyffier Et Al Meta-analysismentioning

confidence: 99%