Effects of Treatment for Paediatric Cancer on Brain Structure and Function

Murdoch, Bruce E.; Hudson, Lisa J; Boon, Deborah L

doi:10.1002/9780470699232.ch2

Cited by 2 publications

(1 citation statement)

References 126 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surgical removal of a tumour in the right cerebellar hemisphere was also reported by Riva and Giorgi [3,5] to be associated with deficits in thinking flexibility and problem solving. It is also considered that a presentation of reduced problem solving ability at initial assessment followed by a pattern of decline in the profile of case 1 may highlight a structural and functional deterioration that more closely relates to recognized treatment effects associated with radiotherapy use in childhood patients [14][15][16] . Demonstrated enhanced treatment effects in the context of increased time after treatment have also been widely reported, with evidence of progressive intellectual deterioration following radiotherapy treatment for paediatric brain tumour [17][18][19][20][21][22][23] .…”

Section: Discussion Of Casesmentioning

confidence: 99%

The Impact of a Cerebellar Tumour on Language Function in Childhood

Docking

Murdoch

Suppiah

2007

Folia Phoniatr Logop

View full text Add to dashboard Cite

Background/Aims:Childhood-acquired cerebellar studies to date have appeared to present a concordant pattern of specific neuropsychological profiles depending on lesion site. The aim was to determine the impact of a cerebellar tumour specifically on language function in children by reporting both the general and high-level language abilities of 4 cases with differing sites of hemispheric and vermal involvement. Methods: The language abilities of 4 children (aged from 7 years 9 months to 13 years), treated with surgery and/or radiotherapy for cerebellar tumour 6 months to 3 years previously, were examined. A standardized battery of general and high-level language assessments was administered. Results: Analysis revealed intact abilities across all 4 cases on measures of general language, including receptive language, expressive language, receptive vocabulary and naming. While 2 of the 4 cases also demonstrated intact high-level language skills across all measures, the remaining 2 demonstrated specific deficits in linguistic problem solving at 6 months after treatment. Follow-up assessment of 1 case also demonstrated further decline in this area 12 months later. Conclusion: Findings of high-level language deficits in problem solving in 2 of the 4 cases examined supported previous reports of specific impairments in high-level language and in thinking flexibility and problem solving following cerebellar hemispheric damage in childhood.

show abstract