Effects of Treadmill Running on Oxidative Capacity of Regenerated Skeletal Muscle*

Abstract

The purpose of the present study was to examine the effects of treadmill running on the oxidative capacity of regenerated rodent skeletal muscle. The soleus, plantaris, and gastrocnemius muscles were removed under general anesthesia from one hindlimb of young female rats (N = 15). The visible "white" portion of the latter muscle was minced into 1 mm3 fragments and autotransplanted leaving both the tibial and sural nerves intact. Six animals were treadmill run daily beginning 4 days post-surgery. Intensity and duration were progressively increased such that by day 45 the animals were running 1 h at 21.5 m . min-1 up a 15% grade, The regenerated muscle homogenates had a significantly lower capacity for maximal pyruvate + malate oxidation and smaller mass relative to the contralateral gastrocnemius. The exercise program significantly increased these parameters, tending to normalize the values. Some factor associated with exercise stimulated recovery from the muscular trauma.

An acellular biologic scaffold does not regenerate appreciable de novo muscle tissue in rat models of volumetric muscle loss injury

“…In this study, rats with VML injured muscle repaired with a porcine UBM scaffold were subjected to physical rehabilitation (i.e., voluntary wheel running) beginning either one week or four weeks postinjury. Physical rehabilitation has been shown to foster regeneration of injured muscle using muscle grafts [7,56,57], and is postulated to improve ECM mediated tissue remodeling [42,58,59]. However, in this study, regardless of the time of initiation of physical rehabilitation, neither muscle fiber regeneration nor function of the porcine UBM scaffold repaired muscles improved compared to no rehabilitation.…”

“…It is possible that a different modality or a prescribed running regimen may elicit performance improvements. However, in recognition of the literature [7,56,57], the current results underscore that the efficacy of physical rehabilitation is likely to increase synergy only when appreciable de novo muscle tissue regeneration is realized.…”

Autologous minced muscle grafts: a tissue engineering therapy for the volumetric loss of skeletal muscle

“…In an attempt to improve the histomorphology of the regenerated tissue, a subset of rats in this study were given access to voluntary running wheels. Although this mode of exercise may not be the most clinically relevant, running activity has been shown previously to improve regeneration following toxin-induced injury (61) and to increase protein content and/or muscle mass of whole soleus muscle grafts (19,68) and tissue regenerated from minced gastrocnemius muscle (66). To this effect, wheel running altered the phenotype of the regenerated fibers, marked by a reduced collagen 1 content in the defect area.…”

Efeitos de diferentes esforços de luta de judô na atividade enzimática, atividade elétrica muscular e parâmetros biomecânicos de atletas de elite

“…Opposed to Kellis (17) , it could be verified in the 180sec fight an increase in the amplitude of the iEMG signal of the antagonist muscle, suggesting the muscle has an important role for the stability of the joint as a motor controlling of the regulation, and to the protection of the joints in a fatigue process (24) . An explanation for such increase can be attributed to a central nervous system attempt to compensate the muscular fatigue through the increase in the number of motor units available (25) .…”

“…On the other hand, such co-activation suggests debility in the activation performance of the muscles to the accomplishment of the motor action, and this could pose a damage to the functional performance (24) . The optimization of the strength training aiming the athlete's performance has as purpose the activation of the agonist muscles with or without low antagonist co-activation (16,22) .…”