Effects of transplantation of olfactory ensheathing cells in chronic spinal cord injury: a systematic review and meta-analysis

Li, Lei; Adnan, Hafeez; Xu, Benchen; Wang, Jianmin; Wang, Chengke; Li, Fang; Tang, Kai

doi:10.1007/s00586-014-3416-6

Cited by 63 publications

(52 citation statements)

References 48 publications

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“…202 Subsequently studies transplanted mucosal tissue, as opposed to 42 purified OECs, with conflicting results 203 204 Other trials have investigated other transplanted cells, including OECs and olfactory nerve fibroblasts, Schwann cells and a combination of OECs and Schwann cells 205,206 . A systematic review of the use of OECs in SCI echoed the positive findings found in other trials 207 . More recently, data from a phase 1 trial reported motor and sensory improvements and no serious adverse events 1 year post transplantation of autologous mucosal OECs and olfactory nerve fibroblasts into the spinal cords of patients with AIS impairment grade A injuries (n=6) 205 .…”

Section: [H2] Current Clinical Studiesmentioning

confidence: 72%

Traumatic Spinal Cord Injury

Cadotte¹,

Fehlings²

2014

Quantitative MRI of the Spinal Cord

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Section: [H2] Current Clinical Studiesmentioning

confidence: 72%

Traumatic Spinal Cord Injury

Cadotte¹,

Fehlings²

2014

Quantitative MRI of the Spinal Cord

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“…At least 10 studies of patients with chronic SCI treated with OECs have been described (cumulative n = 1,193). A recent meta‐analysis found no significant increase in adverse events after OEC transplant; however, higher‐quality studies are still required to define efficacy [102].…”

Section: Cell‐based Approachesmentioning

confidence: 99%

Concise Review: Bridging the Gap: Novel Neuroregenerative and Neuroprotective Strategies in Spinal Cord Injury

Ahuja

Fehlings

2016

Stem Cells Translational Medicine

172

141

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Spinal cord injuries (SCIs) result in devastating lifelong disability for patients and their families. The initial mechanical trauma is followed by a damaging secondary injury cascade involving proapoptotic signaling, ischemia, and inflammatory cell infiltration. Ongoing cellular necrosis releases ATP, DNA, glutamate, and free radicals to create a cytotoxic postinjury milieu. Long-term regeneration of lost or injured networks is further impeded by cystic cavitation and the formation of an inhibitory glial-chondroitin sulfate proteoglycan scar. In this article, we discuss important neuroprotective interventions currently applied in clinical practice, including surgical decompression, blood pressure augmentation, and i.v. methylprednisolone. We then explore exciting translational therapies on the horizon, such as riluzole, minocycline, fibroblast growth factor, magnesium, and hypothermia. Finally, we summarize the key neuroregenerative strategies of the next decade, including glial scar degradation, Rho-ROCK inhibition, cell-based therapies, and novel bioengineered adjuncts. Throughout, we emphasize the need for combinatorial approaches to this multifactorial problem and discuss relevant studies at the forefront of translation. We conclude by providing our perspectives on the future direction of SCI research. STEM CELLS TRANSLATIONAL MEDICINE 2016;5:914-924 SIGNIFICANCESpinal cord injuries (SCIs) result in devastating, lifelong disability for patients and their families. This article discusses important neuroprotective interventions currently applied in clinical practice, including surgical decompression, blood pressure augmentation, and i.v. methylprednisolone. Translational therapies on the horizon are discussed, such as riluzole, minocycline, fibroblast growth factor, magnesium, and hypothermia. The key neuroregenerative strategies of the next decade are summarized, including glial scar degradation, Rho-ROCK inhibition, cell-based therapies, and novel bioengineered adjuncts. The need for combinatorial approaches to this multifactorial problem is emphasized, relevant studies at the forefront of translation are discussed, and perspectives on the future direction of SCI research are presented.

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“…Partial functions and the quality of life have been improved following transplantation of cells into cord parenchyma, intrathecal administration of cells (lesion area or lumbar subarachnoid space), intravascular infusion of cells, and by multiple routes of administration. 11,[58][59][60][61][62][63][64][65][66][67][68] Increasing studies have showed that extracellular vesicles such as exosomes have recently been suggested to mediate neurorestorative effects, [69][70][71] and may offer a possible alternative therapeutic strategy for SCI in future.…”

Section: Cell Therapymentioning

confidence: 99%

Clinical therapeutic guideline for neurorestoration in spinal cord injury (Chinese version 2016)

Feng¹,

Sun²,

Chen³

et al. 2017

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Abstract:Restoring functions following spinal cord injury (SCI) was the most challenging task in clinical practice in the past. Fortunately, some effective neurorestorative methods have been exploited in acute, subacute, and chronic phase of SCI. There were no clinical neurorestorative therapeutic guidelines available before this document which can be followed by physicians to manage patients with acute, subacute, and chronic SCI. This guideline will be a helpful reference to physicians to implement their neurorestorative strategies that can help to improve the neurological functions in patients with SCI and their quality of life.

show abstract

Effects of transplantation of olfactory ensheathing cells in chronic spinal cord injury: a systematic review and meta-analysis

Cited by 63 publications

References 48 publications

Traumatic Spinal Cord Injury

Traumatic Spinal Cord Injury

Concise Review: Bridging the Gap: Novel Neuroregenerative and Neuroprotective Strategies in Spinal Cord Injury

Clinical therapeutic guideline for neurorestoration in spinal cord injury (Chinese version 2016)

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