Effects of Transferrin Genetic Phenotypes on Total Iron-Binding Capacity

Wong, C T; Saha, N

doi:10.1159/000206128

Cited by 37 publications

(18 citation statements)

References 11 publications

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“…serum iron, TIBC, TF saturation and serum ferritin. In two previous studies [21,22] there were indications that the TIBC value was lower in TFC2 and TFC2-I. In the present study the TFC2 variant was not associated with decreased TIBC values; lor both males and females the TIBC levels were very similar in the TFC1 and C2-1 types.…”

Section: Resultssupporting

confidence: 57%

“…The to tal material was, however, rather small (n = 84), and no division by sex was done. Wong and Saha [21] studied TF types in relation to TF levels and TIBC in a series of 297 males. There were no significant differences between 338 Sikstrom/Beekman/Hallmans/Asplund Transferrin, Iron-Binding and Body Iron Stores electrophoretic (B, C and D) variants and TFC (Cl and C2) subtypes with respect to se rum TF concentrations measured by rocket immunoelectrophoresis.…”

Section: Introductionmentioning

confidence: 99%

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Transferrin Types, Iron-Binding Capacity and Body Iron Stores

Síkström

Beckman²,

Hallmans³

et al. 1993

Hum Hered

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Increased body iron stores and transferrin (TF) variants have been found to be associated with adverse health effects believed to be caused by oxygen free radicals. Previous attempts to establish a relationship between TF types, serum TF concentrations and iron-binding have been inconclusive. We have studied serum iron, total iron-binding capacity (TIBC), TF saturation and serum ferritin in relation to genetic TF types in a population sample (691 females and 639 males) from northern Sweden in an attempt to elucidate whether individuals with TF variants associated with adverse somatic and reproductive effects (TFC2 and C3) have increased body iron stores. As expected there was a highly significant sex difference, males manifesting increased body iron stores viz. increased levels of serum iron, TF saturation and serum ferritin, and a lower TIBC. There was no consistent and statistically significant association between the TFC2 variant and the parameters that indicate iron binding and storage. Thus the associations between TFC2 and somatic and reproductive damage appear to be independent of iron binding and body iron stores. TIBC (and TF levels) showed significant differences between TF types in females (p = 0.0015) but not in males. In females the TFC3 variant was associated with a significantly lower (p = 0.002) TIBC value. This decreased TIBC value was, however, not accompanied by an increased ferritin value, thus there was no unequivocal evidence for an association between TFC3 and increased body iron stores.

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Section: Resultssupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Transferrin Types, Iron-Binding Capacity and Body Iron Stores

Síkström

Beckman²,

Hallmans³

et al. 1993

Hum Hered

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“…The samples were phenotyped for transferrin types by polyacrylamide gel isoelectric focusing (LKB Ampholine pH 3.5-10) after neuraminidase treat ment [4], Statistical analysis was performed using Statpak software on an IBM personal computer. The signifi cance of difference between parameters in different groups was tested by Student's t test.…”

Section: Methodsmentioning

confidence: 99%

“…Tf C is very polymorphic in all the human populations so far investigated but there is little information on the selective forces which maintain it at such high poly morphic levels. In a recent paper it has been shown that the different genetic types of transferrin differ significantly in their total iron-binding capacity [4], Total iron-binding capacity of TfC2 was found to be signifi cantly lower than that of TfC]. There is also some suggestive evidence for selective ad vantage of Tfc 1 over TfC2.…”

Section: Introductionmentioning

confidence: 96%

Lack of Influence of Maternal and Fetal Transferrin Phenotypes and Concentrations on Normal Fetal Growth

Wong¹,

Saha

1991

Neonatology

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“…Transferrin is the protein that safely carries iron in an inactive form in the blood. A ge netic isoform of transferrin (Tf C2) has been shown to have a decreased iron binding capacity, and appears to fail partially in carrying iron in this inactivated form (Wong & Saha, 1986). This allows active iron to react with oxygen species in the blood to form ROS.…”

Section: Useful Ros Production In the Bodymentioning

confidence: 99%

The free radical theory of ageing

Rensburg¹,

Potocnik²

1998

SAJOG

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The free radical theory o f ageing hypothesizes that ageing is a consequence o f incomplete inactivation o f certain harmful toxins (called reactive oxygen species, or ROS) by the defence systems o f the body. R OS are produced by the body as a direct consequence o f its need fo r oxygen to survive. They are produced either accidentally, in the process o f energy production, or deliberately, to annihilate bacteria and viruses. ROS produced in excess damage cell membranes, proteins and even DNA. It is hypothesized that the damage cannot always be reversed and hence causes the deteriora tion seen in the body during ageing.The nature of the mechanisms underlying the ageing process is presently not well understood. A theoretical maximum life span of about 120 years for humans was proposed by Hayflick (1974), following his investigations of the potential capacity of cells to divide only a fixed number of times before dying. Several hypotheses have been proposed to identify mechanisms which are associated with longevity -one of which is the free radical theory of ageing.

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Effects of Transferrin Genetic Phenotypes on Total Iron-Binding Capacity

Cited by 37 publications

References 11 publications

Transferrin Types, Iron-Binding Capacity and Body Iron Stores

Transferrin Types, Iron-Binding Capacity and Body Iron Stores

Lack of Influence of Maternal and Fetal Transferrin Phenotypes and Concentrations on Normal Fetal Growth

The free radical theory of ageing

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