Effects of Transdermal Testosterone on Bone and Muscle in Older Men With Low Bioavailable Testosterone Levels

Kenny, Anne M.; Prestwood, Karen M.; Gruman, Cynthia; Marcello, K.; Raisz, Lawrence G.

doi:10.1093/gerona/56.5.m266

Cited by 403 publications

(308 citation statements)

References 33 publications

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“…A positive correlation between the change in FM and serum testosterone was seen in the Page et al 32 study. Smaller decreases in FM are seen after 6-12 months of testosterone supplementation in older eugonadal men 35,39,48,49 and following 90 days of treatment in overweight/obese hypogonadal older men. 50 Synthetic androgens (oxandrolone, oxymetholone) are associated with greater loss of FM than is native testosterone in short-term studies.…”

Section: Testosterone and Body Compositionmentioning

confidence: 94%

“…37 Functional correlates of this increase in muscle mass are uncertain, 38 although measures of muscle strength assessed in short-term studies do suggest benefits with treatment. [39][40][41] Dihydrotestosterone 42 and human chorionic gonadotrophin (hCG) 43 over a 3-month period have also demonstrated improvement in selected aspects of muscle strength. While the favourable changes in FFM consistently demonstrated in short-term controlled studies may have important sequelae with regard to physical functioning, to date only surrogate predictors (strength, activity) of the desired end effects (for example, independent living, prevention of falls) have been studied.…”

Section: Testosterone and Body Compositionmentioning

confidence: 99%

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Body composition, metabolic syndrome and testosterone in ageing men

Allan¹,

Strauss

McLachlan

2007

Int J Impot Res

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The ageing process in men is marked by changes in body composition (loss of fat-free mass (FFM) and skeletal muscle, and gain in fat mass (FM)) and is associated with a decline in serum testosterone. Correlations between these aspects of ageing and the acknowledged role of exogenous testosterone in reversing the loss of FFM and gain in FM seen in adult men with congenital or acquired hypoandrogenism have led to the hypothesis that testosterone therapy in ageing men will result in favourable changes in body composition and may improve metabolic status and/or cardiovascular risk. Data from randomized controlled trials of testosterone therapy in ageing men addressing the endpoints of body composition and components of the metabolic syndrome and cardiovascular risk factors are reviewed, and the impact of the increasing prevalence of obesity on these relationships is considered.

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Section: Testosterone and Body Compositionmentioning

confidence: 94%

Section: Testosterone and Body Compositionmentioning

confidence: 99%

Body composition, metabolic syndrome and testosterone in ageing men

Allan¹,

Strauss

McLachlan

2007

Int J Impot Res

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“…Therapies associated to testosterone and other androgenic hormone treatment favor changes in body composition, especially in lean mass gain and neuromuscular adaptation (Allan et al 2008;Schroeder et al 2004;Page et al 2005;Kenny et al 2001;Schroeder et al 2003a). However, the effects of these types of treatment are not fully understood, since their objectives, dosages and duration as well as the association with physical activity adds complexity to the data provided by the studies on this theme (Kenny et al 2000;Morley et al 2003;Snyder et al 1999;Tenover 1998).…”

Section: Introductionmentioning

confidence: 99%

Effects of testosterone on lean mass gain in elderly men: systematic review with meta-analysis of controlled and randomized studies

Neto

Gama

Rocha

et al. 2015

AGE

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The objective of this study was to evaluate the effects of steroid anabolic androgenic hormones use on lean mass gain in elderly men through a systematic review with a meta-analysis of randomized controlled studies. We systematically searched PubMed database until 4th October 2013. We included randomized placebo-controlled trials (RCT) that studied testosterone replacement therapy in men over 60 years of age, with total testosterone levels ≤550 ng/dl, observing gains in weight, lean mass tissue and fat mass as outcome. We excluded duplicated studies, studies which mixed men and women, and studies using weak androgens such as dehydroepiandrosterone or androstenedione. The initial search yielded 2681 articles, of which 26 were selected for full text analysis. In the end, 11 studies were included. However, 3 studies were not included in the metaanalysis. Meta-analysis showed that mean weight increased (lean mass), ranging from 1.65 (95 % CI, AGE (2015) ) kg, although it was heterogeneous (I 2 =98 %). Effect estimate was 3.59 [2.38-4.81]. Androgen therapy decreased fat mass; effect estimate was −1.78 [−2.57, −0.99] that analysis had also a high level of heterogeneity (I 2 =81 %). The results suggest that testosterone replacement therapy is able to increase muscle mass in elderly men and that is affected by the time that the treatment is carried out and the method of administration of the drug.

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“…The Fourth Korean National Health Survey has also found a prevalence ranging from 0.1% (using the classical Baumgartner definition with 2 SD cutoff) to 11.8% (using appendicular skeletal muscle mass adjusted by body weight) in the elderly women. 17 Dam et al 18 28 ] and six clinical trials [29][30][31][32][33][34] regarding the operational criterion agreement. 18,35 They found poor agreement (varying from 4.0% to 19.9% in women, evaluated by Cohen's kappa test) for the positive results of the studies.…”

Section: Discussionmentioning

confidence: 99%

Sarcopenia: evaluation of different diagnostic criteria and its association with muscle strength and functional capacity

Salame

Costa

Zottele

et al. 2015

Rev. bras. geriatr. gerontol.

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Introduction: Sarcopenia has been associated with increased morbidity and mortality in older people. However, there is still no consensus about the best diagnostic criteria for it.Objective: This study aimed to evaluate different diagnostic criteria of sarcopenia and their relationship with muscle strength and functional capacity. Methods: A cross-sectional study was carried out in Santa Maria-RS, Brazil. Body composition was measured by dual-energy X-ray absorptiometry (DXA). Physical performance was evaluated by the Timed-get-up-and-go test (TGUG). Muscle strength was measured with a handgrip dynamometer. The proposed criteria of sarcopenia were evaluated as follows: A) appendicular lean mass index (aLM/ht 2 ), cutoffs 5.5 kg/m 2 , 2SD, 10 th percentile, and 20 th percentile of young reference; B) a linear regression model was used to adjust appendicular lean mass (aLM) for both height and fat mass, cutoff 20 th percentile of elderly. Results: In total, 104 women agreed to participate in the research, 39 young (20 to 40 years) and 65 elderly (over 60 years). The prevalence of sarcopenia varied from 0% to 17.2% according to the diagnostic criteria. Regarding muscle strength, the aLM/ht 2 cutoff 10 th percentile was the criterion with greater area under the ROC curve. However, there were no criteria with an area under the ROC curve greater than 0.5 when TGUG was the outcome. The reclassification showed that the criterion B reclassified 66.7% with normal grip strength as sarcopenic. Conclusion: Of these criteria, aLM/ht 2 cutoff 10 th percentile had stronger correlation with muscle strength.

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Effects of Transdermal Testosterone on Bone and Muscle in Older Men With Low Bioavailable Testosterone Levels

Cited by 403 publications

References 33 publications

Body composition, metabolic syndrome and testosterone in ageing men

Body composition, metabolic syndrome and testosterone in ageing men

Effects of testosterone on lean mass gain in elderly men: systematic review with meta-analysis of controlled and randomized studies

Sarcopenia: evaluation of different diagnostic criteria and its association with muscle strength and functional capacity

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