Effects of transdermal scopolamine upon psychological test performance at sea

Parrott, Andrew C.; Jones, R. Kevin

doi:10.1007/bf00544360

Cited by 16 publications

(26 citation statements)

References 11 publications

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“…The unchanged reaction times (table II); [also Parrott, 1986;Parrott and Jones, 1985], indicate that the number of letters scanned was unchanged, while the increased omission errors indicate a significant impairment in sus tained attention (table II). Gordon ct al.…”

Section: Discussionmentioning

confidence: 99%

“…Letter cancellation omission errors were significantly increased by transdermal scopolamine in previous land-based and shipboume trials [Parrott, 1986;Parrott, unpubl. b;Parrott and Jones, 1985]. Let ter cancellation represents a visual scanning task which requires continous attention for optimal performance.…”

Section: Discussionmentioning

confidence: 99%

“…Parrott [1986] compared the effects of transder mal scopolamine with different doses of oral scopol amine; significant impairments were reported on tasks of sustained attention, and memory for new information, with both transdermal and oral scopolamine. Parrott and Jones [1985] similarly reported a significant decre ment on a task of sustained attention, with transdermal scopolamine at sea.…”

mentioning

confidence: 95%

“…Furthermore, in the few studies involving repeated patches that have been undertaken, visual problems (blurred vision, re duced accommodation) have been reported, particularly following the later patches [Graybiel et al, 1982;Homick et al, 1983;Parrott and Jones, 1985]. The effects of scopolamine upon vision have been summarised by Innés and Nickerson [1975]: 'The atropinic drugs (atro pine, scopolamine) block the responses of... the ciliary muscle of the lens to cholinergic stimulation ... the lens is Fixed for far vision, near objects are blurred.…”

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confidence: 99%

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Transdermal Scopolamine: Effects of Single and Repeated Patches upon Psychological Task Performance

Parrott¹

1987

Neuropsychobiology

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Scopolamine and placebo transdermal patches were applied on alternating days to 12 normal volunteer subjects. Psychological performance tasks, physiological assessments, a subjective feeling state questionnaire, and a sleep questionnaire were completed each day. Transdermal scopolamine produced significant decrements in memory task performance, daytime feelings of alertness, ease of waking, and alertness following waking, while resting heart rates were lowered. Significant drug × patch number interaction effects were present with memory for new information, letter cancellation omission errors, rapid visual information processing reaction time, and self-rated ease of getting to sleep, but there was no consistent pattern to the changes following successive patches. Visual problems (blurred vision, longer visual near point) increased following successive scopolamine patches, but the changes in task performance were not related to these visual changes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 95%

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confidence: 99%

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Transdermal Scopolamine: Effects of Single and Repeated Patches upon Psychological Task Performance

Parrott¹

1987

Neuropsychobiology

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“…Visual problems have been reported following both oral and transdermal hyoscine (Lukomskya, 1971;Parrott and Jones, 1985;Parrott, 1986b), with blurred vision, and impaired visual near-point focusing reported. These problems increase in frequency following successive transdermal scopolamine patches, with more subjects developing blurred vision, and a steady increase in visual nearpoint (Parrott, 1986b).…”

Section: Introductionmentioning

confidence: 99%

The effects of single and repeated doses of oral scopolamine, cinnarizine, and placebo upon psychological performance and physiological functioning

Parrott

Golding²,

Pethybridge

1990

Human Psychopharmacology

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The present study was one in a series in the Institute of Naval Medicine's Motion Illness Project. A battery of psychological performance tests (producing 26 indices of mental and hand-eye co-ordination), together with visual near fixation point, resting heart rate and a self-rated feeling state questionnaire, were used to compare the effects of thrice-daily oral doses of scopolamine (0.6mg), cinnarizine (30mg) and a lactose placebo in a double-blind crossover trial on 12 healthy male volunteers. Measurements were made 1-2 h and 5-6 h after the initial dose, then the next day following the last successive dose (1-2 and 5-6 h after the fourth dose; or 25-26 and 29-30 h after the initial dose). Scopolamine demonstrated clear physiological effects, with reduced heart rate from the first oral dose onwards, and visual near-point values increasingly distant over successive doses. Cinnarizine did not produce significant physiological changes. Neither drug produced significant effects on subjective mood. Significant ANOVA drug effects or drug x time interaction effects were present with five out of the 26 performance variables: logical reasoning error, memory word-recall errors; continuous four choice reaction time; concept identification time; SERS task commission error. However only two of these (memory error, four choice reaction time) demonstrated patterns of effect which were considered to be attributable to the drugs. Both cinnarizine and scopolamine impaired memory error and four choice reaction time. Only for visual near-point with scopolamine was there evidence that repeated dosing led to increasing physiological/mental performance effects.

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Transdermal scopolamine: Effects of single and repeated patches upon aspects of vision

Parrott¹

1986

Human Psychopharmacology

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Transdermal scopolamine and transdermal placebo patches were administered on alternating days to 12 normal volunteer subjects. Visual near-point values and self-reports of blurred vision were systematically assessed 24 hours following each transdermal patch. Blurred vision was not reported following the first scopolamine patch, but became increasingly frequent following successive scopolamine patches. Six of the 12 subjects reported blurred vision by their fourth scopolamine patch. Subjects reporting blurred vision had long initial visual near-points (i.e. were comparatively hypermetropic), whereas subjects not reporting blurred vision had short initial visual near-points (i.e. were comparatively myopic). The visual near-point values of the (hypermetropic) subjects who developed blurred vision became longer following each successive scopolamine patch, whereas the visual near-point values of the (myopic) subjects not reporting blurred vision remained basically unchanged. Visual changes following scopolamine have been previously shown to be slow to develop and slow to dissipate; this slow time course probably produced the cumulative visual problems reported here.

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Effects of transdermal scopolamine upon psychological test performance at sea

Cited by 16 publications

References 11 publications

Transdermal Scopolamine: Effects of Single and Repeated Patches upon Psychological Task Performance

Transdermal Scopolamine: Effects of Single and Repeated Patches upon Psychological Task Performance

The effects of single and repeated doses of oral scopolamine, cinnarizine, and placebo upon psychological performance and physiological functioning

Transdermal scopolamine: Effects of single and repeated patches upon aspects of vision

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