Effects of Transcutaneous Electrical Acustimulation on Refractory Gastroesophageal Reflux Disease

Meng, Li Na; Chen, Shanshan; Chen, Jiande D.Z.; Jin, Hai Feng; Lü, Bin

doi:10.1155/2016/8246171

Cited by 22 publications

(38 citation statements)

References 23 publications

(29 reference statements)

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“…The effect was probably mediated via the autonomic mechanisms . A recent study reported that TEA improved symptoms in refractory GERD patients by increasing LESP and decreasing events of weak and acid reflux . However, the underlying mechanism of TEA on GERD has not been explored in this study.…”

Section: Introductionmentioning

confidence: 74%

Elevation of Lower Esophageal Sphincter Pressure With Acute Transcutaneous Electrical Acustimulation Synchronized With Inspiration

Liu

Guo

et al. 2019

Neuromodulation: Technology at the Neural Interface

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Section: Introductionmentioning

confidence: 74%

Elevation of Lower Esophageal Sphincter Pressure With Acute Transcutaneous Electrical Acustimulation Synchronized With Inspiration

Liu

Guo

et al. 2019

Neuromodulation: Technology at the Neural Interface

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“…Without the need to come to the hospital, the compliance of the TEA is substantially increased. Possibly attributed to these above factors, TEA was reported to be effective in treating GERD, functional dyspepsia, and functional constipation in a few small‐scale single‐center studies . The disadvantage of delivering electrical current superficially to the skin rather than deep into the acupuncture point seemed to be compensated by more frequent administrations of TEA.…”

Section: Types Of Electroacupuncture and Its Deliverymentioning

confidence: 99%

“…In one study, EA at ST36, PC6, and some other points in combination with a conventional proton pump inhibitor (PPI) was found to be more effective than doubling PPT dose in reducing symptoms of heartburn and acid regurgitation in patients with GERD . In a more recent study, TEA at ST36 plus PPI was found more effective than PPI plus sham‐TEA in treating reflux symptoms and elevating lower esophageal sphincter pressure in patients with refractory GERD . Apparently more controlled studies are needed to establish the role of EA for treating GERD.…”

Section: Ea and Tea Treatments For Gut Dysmotilitymentioning

confidence: 99%

“…Possibly attributed to these above factors, TEA was reported to be effective in treating GERD, functional dyspepsia, and functional constipation in a few small-scale single-center studies. [12][13][14][15] The disadvantage of delivering electrical current superficially to the skin rather than deep into the acupuncture point seemed to be compensated by more frequent administrations of TEA. However, large scale multi-center studies are F I G U R E 1 Acupuncture (left), electroacupuncture (middle), and transcutaneous electrical acustimulation (right) KeyPoints • Acupuncture can be classified into manual acupuncture, electroacupuncture and transcutaneous electrical acustimulation.…”

Section: Acupuncture Ea and Teamentioning

confidence: 99%

“…26 In a more recent study, TEA at ST36 plus PPI was found more effective than PPI plus sham-TEA in treating reflux symptoms and elevating lower esophageal sphincter pressure in patients with refractory GERD. 12 Apparently more controlled studies are needed to establish the role of EA for treating GERD.…”

Section: Ea and Tea For Gerdmentioning

confidence: 99%

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Electroacupuncture treatments for gut motility disorders

Chen¹,

Yin³

2018

Neurogastroenterology Motil

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Functional gastrointestinal (GI) diseases are common and there are patients who are refractory to medical therapies as not all treatments work in all patients. Consequently, a large number of patients with functional GI diseases use complementary and alternative medicine, such as acupuncture or electroacupuncture (EA). In this issue, Zheng et al. reported interesting results of a multi-center placebo-controlled clinical study on the use of EA for treating refractory functional dyspepsia; another study reported a multi-center clinical trial on EA for chronic functional constipation; Liang et al. studied mechanisms of EA involving enteric nervous system and neurotransmitters in treating constipation in rats. While controversial reports are available in the literature, EA with appropriate methodologies as shown in these recent studies is believed to be effective in treating certain functional GI diseases. In this mini-review, a number of clinical studies, including those included in this issue on the use of EA for treating gastro-esophageal reflux, functional dyspepsia, irritable bowel syndrome, and constipation are reviewed. Some critically important issues, such as the choice of stimulation parameters for EA, the administration frequency of the therapy, and the appropriate choice of placebo for clinical research are also discussed. Mechanisms of action involved in the therapeutic effects of EA for gut dysmotility and future research directions are also presented.

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Class side effects: decreased pressure in the lower oesophageal and the pyloric sphincters after the administration of dopamine antagonists, neuroleptics, anti-emetics, l-NAME, pentadecapeptide BPC 157 and l-arginine

et al. 2017

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The ulcerogenic potential of dopamine antagonists and L-NAME in rats provides unresolved issues of anti-emetic neuroleptic application in both patients and experimental studies. Therefore, in a 1-week study, we examined the pressures within the lower oesophageal and the pyloric sphincters in rats [assessed manometrically (cm HO)] after dopamine neuroleptics/prokinetics, L-NAME, L-arginine and stable gastric pentadecapeptide BPC 157 were administered alone and/or in combination. Medication (/kg) was given once daily intraperitoneally throughout the 7 days, with the last dose at 24 h before pressure assessment. Given as individual agents to healthy rats, all dopamine antagonists (central [haloperidol (6.25 mg, 16 mg, 25 mg), fluphenazine (5 mg), levomepromazine (50 mg), chlorpromazine (10 mg), quetiapine (10 mg), olanzapine (5 mg), clozapine (100 mg), sulpiride (160 mg), metoclopramide (25 mg)) and peripheral(domperidone (10 mg)], L-NAME (5 mg) and L-arginine (100 mg) decreased the pressure within both sphincters. As a common effect, this decreased pressure was rescued, dose-dependently, by BPC 157 (10 µg, 10 ng) (also note that L-arginine and L-NAME given together antagonized each other's responses). With haloperidol, L-NAME worsened both the lower oesophageal and the pyloric sphincter pressure, while L-arginine ameliorated lower oesophageal sphincter but not pyloric sphincter pressure, and antagonized L-NAME effect. With domperidone, L-arginine originally had no effect, while L-NAME worsened pyloric sphincter pressure. This effect was opposed by L-arginine. All these effects were further reversed towards a stronger beneficial effect, close to normal pressure values, by the addition of BPC 157. In addition, NO level was determined in plasma, sphincters and brain tissue. Thiobarbituric acid reactive substances (TBARS) were also assessed. Haloperidol increased NO levels (in both sphincters, the plasma and brain), consistently producing increased TBARS levels in the plasma, sphincters and brain tissues. These effects were all counteracted by BPC 157 administration. In conclusion, we revealed that BPC 157 counteracts the anti-emetic neuroleptic class side effect of decreased pressure in sphincters and the dopamine/NO-system/BPC 157 relationship.

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Effects of Transcutaneous Electrical Acustimulation on Refractory Gastroesophageal Reflux Disease

Cited by 22 publications

References 23 publications

Elevation of Lower Esophageal Sphincter Pressure With Acute Transcutaneous Electrical Acustimulation Synchronized With Inspiration

Elevation of Lower Esophageal Sphincter Pressure With Acute Transcutaneous Electrical Acustimulation Synchronized With Inspiration

Electroacupuncture treatments for gut motility disorders

Class side effects: decreased pressure in the lower oesophageal and the pyloric sphincters after the administration of dopamine antagonists, neuroleptics, anti-emetics, l-NAME, pentadecapeptide BPC 157 and l-arginine

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