Effects of transcranial direct current stimulation (tDCS) on cognition, symptoms, and smoking in schizophrenia: A randomized controlled study

Smith, Robert C.; Boules, Sylvia; Mattiuz, Sanela; Youssef, Mary; Tobe, Russell H.; Sershen, Henry; Lajtha, Ábel; Nolan, Karen; Amiaz, Revital; Davis, John M.

doi:10.1016/j.schres.2015.06.011

Cited by 159 publications

(125 citation statements)

References 54 publications

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“…However, further trials with a focus on patients with clearly defined cognitive deficits as well as clinically meaningful cognitive outcome measures are needed to confirm these initial promising findings. Interestingly, one pilot tDCS study (EEG 10/20, anode F3 and cathode FP2) 52 used the MCCB, the gold standard for the assessment of cognitive functioning in schizophrenia trials as primary outcome measure. After 5 days of tDCS (anode: left DLPFC), improvements in the MCCB composite score as well as in the domain scores of working memory and attentionvigilance in the active compared to the sham group could be observed.…”

Section: Results Of Individual Studies (Outcomes)mentioning

confidence: 99%

“…After 5 days of tDCS (anode: left DLPFC), improvements in the MCCB composite score as well as in the domain scores of working memory and attentionvigilance in the active compared to the sham group could be observed. 52 In terms of efficacy, one important question is the relationship between symptomatic and cognitive improvement. In antipsychotic trials, a clear relationship could not be established (for a more detailed discussion, see Bora et al 53 ) and the same question has to be raised in NIBS studies.…”

Section: Results Of Individual Studies (Outcomes)mentioning

confidence: 99%

“…40,44,47,52 Out of these 4 studies, one used the Cambridge Neuropsychological Test Automated Battery (CANTAB), 40 one focused on working memory using a silent phonemic Verbal Fluency Task, 44 one focused also on working memory using a verbal n-back task, 47 and one used the MATRICS Consensus Cognitive Battery (MCCB). 52 The remaining 29 studies had global symptoms (N = 12), 13 22 However, as the latter study used the Brainsway H1 deep-TMS coil, 22 one could speculate that the built-in sham mode has been used. For tDCS, 3 trials used different variations of the ramp-up/ramp-down procedure, 41,48,52 but no study used the "built-in study-mode."…”

Section: Study Characteristicsmentioning

confidence: 99%

“…52 The remaining 29 studies had global symptoms (N = 12), 13 22 However, as the latter study used the Brainsway H1 deep-TMS coil, 22 one could speculate that the built-in sham mode has been used. For tDCS, 3 trials used different variations of the ramp-up/ramp-down procedure, 41,48,52 but no study used the "built-in study-mode." The stimulation parameters varied across studies dependent on the target symptoms resulting in a high interstudy heterogeneity for this parameter.…”

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Repetitive Noninvasive Brain Stimulation to Modulate Cognitive Functions in Schizophrenia: A Systematic Review of Primary and Secondary Outcomes

Hasan

Strube

Palm

et al. 2016

SCHBUL

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Despite many years of research, there is still an urgent need for new therapeutic options for the treatment of cognitive deficits in schizophrenia. Noninvasive brain stimulation (NIBS) has been proposed to be such a novel add-on treatment option. The main objective of this review was to systematically evaluate the cognitive effects of repetitive NIBS in schizophrenia. As most studies have not been specifically designed to investigate cognition as primary outcome, we have focused on both, primary and secondary outcomes. The PubMed/MEDLINE database (1985-2015) was systematically searched for interventional studies investigating the effects of repetitive NIBS on schizophrenia symptoms. All interventional clinical trials using repetitive transcranial stimulation, transcranial theta burst stimulation, and transcranial direct current stimulation for the treatment of schizophrenia were extracted and analyzed with regard to cognitive measures as primary or secondary outcomes. Seventy-six full-text articles were assessed for eligibility of which 33 studies were included in the qualitative synthesis. Of these 33 studies, only 4 studies included cognition as primary outcome, whereas 29 studies included cognitive measures as secondary outcomes. A beneficial effect of frontal NIBS could not be clearly established. No evidence for a cognitive disruptive effect of NIBS (temporal lobe) in schizophrenia could be detected. Finally, a large heterogeneity between studies in terms of inclusion criteria, stimulation parameters, applied cognitive measures, and follow-up intervals was observed. This review provides the first systematic overview regarding cognitive effects of repetitive NIBS in schizophrenia.

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Section: Results Of Individual Studies (Outcomes)mentioning

confidence: 99%

Section: Results Of Individual Studies (Outcomes)mentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Repetitive Noninvasive Brain Stimulation to Modulate Cognitive Functions in Schizophrenia: A Systematic Review of Primary and Secondary Outcomes

Hasan

Strube

Palm

et al. 2016

SCHBUL

View full text Add to dashboard Cite

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“…Low intensity current is applied for a constant period of time 10 . The effects of tDCS have been shown to last for some time -30-120 mins 13 even after the end of stimulation period 11,12 tDCS has been shown to be effective in ameliorating the signs and symptoms of various psychiatric disorders including major depressive disorder, schizophrenia, obsessive-compulsive disorder 14,15,16 . Very recently, interest has arisen in the potential effect of tDCSon addiction as it has also shown to be effective in reducing craving and relapse rate in people with alcoholic problems [17][18][19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

Transcranial Direct Current Stimulation: a potential novel treatment for alcohol addiction and abuse

Bhandal

Sultana

Janjua

2018

Bangladesh J Med Sci

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Alcohol use disorder (AUD) is a major global health concern. Many treatment modalities have been used in past to help decrease the use of alcohol. Recently, a growing interest has been seen in neuromodulation as a novel treatment means to reduce alcohol addiction behavior. Studies on the effect of Transcranial Direct Current Stimulation (tDCS), especially over dorsolateral prefrontal cortex (DLPFC) have been conducted that have shown to reduce craving and relapse behavior in AUD. Adverse effects associated with tDCS are found to be minor and are temporary in nature. However, the results are preliminary as only few studies are done. More research on AUD done using tDCS will help improve our knowledge and understanding on the various factors involved in AUD besides helping to prevent the cycle of craving, relapse and abstinent.

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Transcranial direct current stimulation to modulate fMRI drug cue reactivity in methamphetamine users: A randomized clinical trial

Ekhtiari

Soleimani

Kuplicki

et al. 2022

Human Brain Mapping

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Transcranial direct current stimulation (tDCS) has been studied as a therapeutic option to alter maladaptive brain functions associated with chronic substance use.We present a randomized, triple-blind, sham-controlled, clinical trial to determine the neural substrates of tDCS effects on drug craving. Sixty participants with methamphetamine use disorder were assigned to two groups: active tDCS (5 x 7 cm 2 , 2 mA, 20 min, anode/cathode over the F4/Fp1) and sham stimulation. Neuroimaging data of a methamphetamine cue reactivity task were collected immediately before and after stimulation. There was a significant reduction in self-reported craving after stimulation without any significant effect of time-by-group interaction. Our wholebrain analysis demonstrated that there was a global decrease in brain reactivity to cues following sham but not active tDCS. There were significant time-by-group interactions in five main clusters in middle and inferior frontal gyri, anterior insula, inferior parietal lobule, and precuneus with higher activations after active stimulation. There was a significant effect of stimulation type in the relationship between electrical current at the individual level and changes in task-modulated activation. Brain regions with the highest electric current in the prefrontal cortex showed a significant timeby-group interaction in task-modulated connectivity in the frontoparietal network. In this trial, there was no significant effect of the one session of active-F4/Fp1 tDCS on drug craving self-report compared to sham stimulation. However, activation and connectivity differences induced by active compared to sham stimulation suggested some potential mechanisms of tDCS to modulate neural response to drug cues.

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Effects of transcranial direct current stimulation (tDCS) on cognition, symptoms, and smoking in schizophrenia: A randomized controlled study

Cited by 159 publications

References 54 publications

Repetitive Noninvasive Brain Stimulation to Modulate Cognitive Functions in Schizophrenia: A Systematic Review of Primary and Secondary Outcomes

Repetitive Noninvasive Brain Stimulation to Modulate Cognitive Functions in Schizophrenia: A Systematic Review of Primary and Secondary Outcomes

Transcranial Direct Current Stimulation: a potential novel treatment for alcohol addiction and abuse

Transcranial direct current stimulation to modulate fMRI drug cue reactivity in methamphetamine users: A randomized clinical trial

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