Effects of transcranial direct current stimulation (tDCS) on binge‐eating disorder

Burgess, Emilee E.; Sylvester, Maria D.; Morse, Kathryn E.; Amthor, Frank; Mrug, Sylvie; Lokken, Kristine; Osborn, Mary Katherine; Soleymani, Taraneh; Boggiano, Mary M.

doi:10.1002/eat.22554

Cited by 84 publications

(136 citation statements)

References 34 publications

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“…Kekic et al found that tDCS reduced food craving more effectively in those with lower vs. greater impulsiveness on a reward-choice task (Kekic et al, 2014), but these were healthy-weight participants. Our lab also found that greater vs. lower intent to restrict calories predicted tDCS suppression of food craving, but these were participants with BED (Burgess et al, 2016). However, both studies hint that greater baseline cognitive control may enhance the anti-obesity actions of tDCS.…”

Section: Introductionmentioning

confidence: 69%

“…Preferred-food consumed was the mean kcal intake of each participant's highest ranked food; less-preferred food consumed was the mean kcal intake of the two lower ranked foods averaged for each participant. The same script, foods, and time period were used in our previous study (Burgess et al, 2016). Eating difference scores were calculated by subtracting kcals eaten with active tDCS from kcals eaten with control tDCS.…”

Section: Methodsmentioning

confidence: 99%

“…The one study using the right anode/left cathode montage was conducted in our laboratory (Burgess et al, 2016) where we found reductions in food craving and food consumption. However, all of the participants with obesity were also diagnosed with binge-eating disorder (BED) or subthreshold BED, and their responses to tDCS cannot be generalized to frank obesity (defined here as non-BED obesity) since BED is a mental disorder with unique neural, behavioral, and psychopathological correlates from non-BED obesity (Balodis et al, 2016; Herbozo, Schaefer, & Thompson, 2015; Schag, Schönleber, Teufel, Zipfel, & Giel, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Hence, investigating the effect of individual differences in cognition-related traits on tDCS responses may elucidate the source for inconsistent results across participants and help predict who might benefit the most from tDCS-based treatments. Additionally, given the promise of a tDCS-based treatment for obesity, it is important to understand the effectiveness of tDCS in both males and females as obesity affects both groups (Ogden et al, 2014) and previous work in our lab found that males and females respond differently to tDCS (Burgess et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

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The critical role of cognitive-based trait differences in transcranial direct current stimulation (tDCS) suppression of food craving and eating in frank obesity

et al. 2017

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Obesity remains a major public health concern and novel treatments are needed. Transcranial direct current stimulation (tDCS) is a neuromodulation technique shown to reduce food craving and consumption, especially when targeting the dorsolateral prefrontal cortex (DLPFC) with a right anode/left cathode electrode montage. Despite the implications to treat frank (non-bingeeating) obesity, no study has tested the right anode/left cathode montage in this population. Additionally, most tDCS appetite studies have not controlled for differences in traits under DLPFC control that may influence how well one responds to tDCS. Hence, N = 18 (10F/8M) adults with frank obesity completed the Dutch Eating Behavior Questionnaire-Restraint and Barratt Impulsiveness Scale, and received 20 min of 2 mA active tDCS and control tDCS session. Craving and eating was assessed at both sessions with a food photo “wanting” test and in-lab measures of total, preferred, and less-preferred kilocalories consumed of three highly palatable snack foods. While main effects of tDCS vs. control were not found, significant differences emerged when trait scores were controlled. tDCS reduced food craving in females with lower attention-type impulsiveness (p = 0.047), reduced preferred-food consumption in males with lower intent to restrict calories (p = 0.024), and reduced total food consumption in males with higher non-planning-type impulsiveness (p = 0.009) compared to control tDCS. This is the first study to find significant reductions in food craving and consumption in a sample with frank obesity using the most popular tDCS montage in appetite studies. The results also highlight the cognitive-based heterogeneity of individuals with obesity and the importance of considering these differences when evaluating the efficacy of DLPFC-targeted tDCS in future studies aimed at treating obesity.

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Section: Introductionmentioning

confidence: 69%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The critical role of cognitive-based trait differences in transcranial direct current stimulation (tDCS) suppression of food craving and eating in frank obesity

et al. 2017

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“…Decreases in sweet cravings, total and preferred food intake, desire to binge eat following tDCS in persons with BED have been reported (Burgess et al 2016) however, impulsive tendencies in choice behavior were shown to be less susceptible to the ameliorating effects of tDCS (Kekic et al 2014). Although in the same study, singlesession tDCS has not been effective in lowering food cravings, same group, in a recent study (Kekic et al 2017), also reported transient improvements on the wanting/liking of food and on bulimic behaviors during the 24-hour post-stimulation following three sessions of bilateral tDCS in patients with bulimia nervosa.…”

Section: Neural Stimulation Therapiesmentioning

confidence: 99%

Dürtüsellik ve Aşırı Yeme Arasındaki İlişki: Psikolojik ve Nörobiyolojik Yaklaşımlar

Atalayer¹

2018

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry

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ÖzEn temel tanımıyla dürtüsellik özdenetim olmadan davranma eğilimidir. Dürtüsellik eğilimi, aşırı yeme ve bununla ilgili belirtilerin ortaya çıkışı ve devamında da önemli bir rol oynamaktadır. Daha detaylı olarak; yüksek düzeydeki dürtüselliğin ve bununla ilişkili olan tepki kontrolünde zorluk, heyecana eğilim, ödül zafiyeti ve olumsuz duygulanım durumlarının, tıkınırcasına yeme bozukluğu-na ve obeziteye kadar ilerleyebilen duygusal yeme üzerinde bir etkileşim etkisine sahip olduğu bulunmuştur. Bu derlemenin amacı, dürtüselliğin aşırı yeme üzerindeki olası rolüne yönelik bilişsel ve nöropsikoloji alanında yapılan çalışmalardan elde edilen kanıtları bir araya getirmek ve bunun yanında obezite ve tıkınırcasına yemek bozukluğunun tedavi yöntemlerine, dürtüsellik özelliği göz önüne alınarak yapılabilecek olası değişiklik ve eklemelere önerme yapmaktır.Anahtar sözcükler: Dürtüsellik, aşerme, tıkınırcasına yeme, obezite, dışsal yeme örüntüsü. AbstractIn most basic terms impulsivity is defined as a tendency to act without control. Impulsivity has been implicated in the onset, symptomatic expression, and maintenance of overeating. Specifically, high impulsivity and associated poor inhibitory control, along with sensation seeking and reward sensitivity, as well as negative affect have been found to have an interaction effect on emotional eating, which may lead to binge eating and obesity. Moreover, associations between overeating and impulsive behaviors such as difficulty in response inhibition, planning, attention, addiction, or risk taking etc. have been previously shown. The purpose of this review is to summarize the evidence from psychology regarding the potential role of the impulsivity trait in overeating, with implications on the treatments for obesity and binge eating.

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A Lack of Clinical Effect of High‐frequency rTMS to Dorsolateral Prefrontal Cortex on Bulimic Symptoms: A Randomised, Double‐blind Trial

Gay

Jaussent

Sigaud

et al. 2016

Euro Eating Disorders Rev

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Studies suggest that stimulation of the left dorsolateral prefrontal cortex (DLPFC) reduces food craving in bulimic patients, but evidence supporting repetitive transcranial magnetic stimulation (rTMS) as a therapeutic tool is lacking. We investigated the safety and therapeutic efficacy of an adjunct high-frequency rTMS programme targeting the left DLPFC. Forty-seven women with bulimia nervosa were randomised to a real or sham stimulation group. The real group underwent 10 rTMS sessions, each consisting of 20 trains of 5 seconds with 55-second intervals between trains, at a frequency of 10 Hz. The main outcome was the number of binge episodes in the 15 days following the end of stimulation. Overall, no significant improvement in bingeing and purging symptoms was noted after the programme. rTMS was well tolerated. This suggests that 10 sessions of high-frequency rTMS to the left DLPFC provide no greater benefit than placebo. Future studies should consider methodological issues as well as alternative targets. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.

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Effects of transcranial direct current stimulation (tDCS) on binge‐eating disorder

Cited by 84 publications

References 34 publications

The critical role of cognitive-based trait differences in transcranial direct current stimulation (tDCS) suppression of food craving and eating in frank obesity

The critical role of cognitive-based trait differences in transcranial direct current stimulation (tDCS) suppression of food craving and eating in frank obesity

Dürtüsellik ve Aşırı Yeme Arasındaki İlişki: Psikolojik ve Nörobiyolojik Yaklaşımlar

A Lack of Clinical Effect of High‐frequency rTMS to Dorsolateral Prefrontal Cortex on Bulimic Symptoms: A Randomised, Double‐blind Trial

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